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Antigen presentation, antigen-presenting cells and antigen processing
Current Opinion in Immunology, 1988To summarize, during the period under review there have been considerable advances in our understanding of how antigen is associated with MHC on the surface of a presenting cell. Basic rules which govern this association have been confirmed as including both the nature and the configuration of the antigen.
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Antigen-presenting cells in allergy
Journal of Allergy and Clinical Immunology, 2001The complex interaction of the innate and adaptive immune system requires flexibility and cooperation among various cell types. In this regard, antigen-presenting-cells (APCs) play a pivotal role in transferring information from the periphery of the organism to lymphoid organs, where they initiate the activation of naive T cells.
Thomas Bieber +2 more
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1985
Three major issues were discussed in the workshop: (1) the role of antigen processing in T-cell activation and situations in which it may not be necessary for T-cell stimulation, (2) the differences in antigen presenting function of macrophages and dendritic cells and the ability of dendritic cells to process antigen, and (3) the role of the type of ...
Kozo Yokomuro, Jay A. Berzofsky
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Three major issues were discussed in the workshop: (1) the role of antigen processing in T-cell activation and situations in which it may not be necessary for T-cell stimulation, (2) the differences in antigen presenting function of macrophages and dendritic cells and the ability of dendritic cells to process antigen, and (3) the role of the type of ...
Kozo Yokomuro, Jay A. Berzofsky
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Are the Mast Cells Antigen Presenting Cells?
Immunological Investigations, 1989Mast cells have an important role in allergic reactions secreting histamine and other mediators of immediate hypersensitivity. In the present study we evaluated major histocompatibility complex (MHC) class II antigen expression in mast cells and their possible role in antigen presentation.
J. Leone +4 more
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Antigen presentation to B cells
Current Opinion in Immunology, 1991B lymphocytes encounter antigen within the body, which causes them to undergo clonal expansion, affinity maturation and differentiation to antibody-forming cells. How they come into contact with the immunogen, and the subsequent response induced is the subject of several recent reports.
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Antigen‐presenting Cells for CD8+ T Cells
Immunological Reviews, 1990Evidence is presented that a wide variety of cell types are capable of presenting class I alloantigens to purified unprimed CD8+ cells in the absence of added help. These cells include dendritic cells, a population of Ia- Thy 1- cells in spleen, peritoneal exudate cells and one of three T-tumor lines. Some cell types, e.g.
Jonathan Sprent, M Schaefer
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Corneal Antigen-Presenting Cells
2007Corneal antigen-presenting cells (APCs) were thought to reside exclusively in the peripheral cornea. However, recent evidence demonstrates that the central cornea is also endowed with a heterogeneous population of bone marrow-derived cells, including epithelial Langerhans cells (LCs) and anterior stromal dendritic cells (DCs), which under certain ...
Pedram Hamrah, Reza Dana
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Antigen-presenting cells for unprimed T cells
Immunology Today, 1989The triggering requirements of T cells differ for primed and unprimed cells: primed T cells can be triggered to produce lymphokines without viable antigen-presenting cells (APCs), apparently by crosslinking the T-cell receptor (TCR). Unprimed T cells do, however, require viable APCs and here Jonathan Sprent and Mary Schaefer review what type of cells ...
Jonathan Sprent, M Schaefer
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Prevention of graft versus host disease by inactivation of host antigen-presenting cells.
Science, 1999Graft versus host disease, an alloimmune attack on host tissues mounted by donor T cells, is the most important toxicity of allogeneic bone marrow transplantation. The mechanism by which allogeneic T cells are initially stimulated is unknown. In a murine
W. Shlomchik +7 more
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Epithelial cell antigen presentation
Current Opinion in Gastroenterology, 2000For decades intestinal epithelial cells were thought of as passive barriers to luminal contents, cells involved in nutrient absorption and electrolyte secretion. Studies during the past 10 to 15 years have changed that concept as our understanding of mucosal immunity has evolved and as we have come to understand that the regulation of this system is ...
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