Results 71 to 80 of about 3,861,164 (348)

Antigenic Variability [PDF]

Frontiers in Immunology, 2020
Protective vaccines for hypervariable pathogens are urgently needed. It has been proposed that amputating highly variable epitopes from vaccine antigens would induce the production of broadly protective antibodies targeting conserved epitopes. However, so far, these approaches have failed, partially because conserved epitopes are occluded in vivo and ...
openaire   +3 more sources

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Epidemiological investigation of poultry infectious in Kazakhstan (2021–2024)

Frontiers in Veterinary Science
IntroductionThis study examines the epidemiological dynamics and genetic diversity of major avian infectious diseases in Kazakhstan, including highly pathogenic avian influenza (HPAI), Newcastle disease virus (NDV), and others.
Karlygash B. Zikibayeva, Asset A. Svanbayev, Nurlan N. Akhmetsadykov, Kamshat N. Kudaibergenova, Shynar N. Akhmetsadykova, Ernur N. Nurolda, Aidyn I. Kydyrmanov   +6 more
doaj   +1 more source

Dynamics of α-D-mannose carbohydrate-binding sites distribution in rats’ pancreatic structures during the morpho-functional formation

Zaporožskij Medicinskij Žurnal, 2017
Recently, the pathology of pancreas in children is observed more frequently. Precursors of inflammation development in pancreas are dysfunctional disorders, which include conditions accompanied by changes in pancreatic secretion in the absence of ...
N. V. Hrinivetska, Yu. A. Burega, I. M. Maslova   +2 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Volatile organic compounds of camel milk and shubat across Kazakhstan's regions, seasons, and breeds

Heliyon
Despite extensive research in recent years on camel milk composition and health benefits, limited scientific data exists on the volatile organic compound profiles of camel milk and its fermented product, shubat.
Zauresh Bilal, Askar Kondybayev, Aikerim Ospanova, Helene Tormo, Shynar Akhmetsadykova, Farida Amutova, Bernard Faye, Gaukhar Konuspayeva   +7 more
doaj   +1 more source

THE MICROPHILOGENY OF THE RACES INVOLVED IN THE FORMING OF MOLDAVIAN TYPE OF BLACK AND WHITE CATTLE

Scientific Papers Animal Science and Biotechnologies, 2023
It was studied and compared the antigens’’ frequency of blood groups in the reproductive horned Black and White cattle (n=542) and other five types of horned cattle: Steppe Red (n=54), Red Estonian (n=330), Simmental (n=34). Jersey (n=56), Ukrainian Grey
V. FOCSHA
doaj  

The BNT162b2 mRNA SARS-CoV-2 vaccine induces transient afucosylated IgG1 in naive but not antigen-experienced vaccinees [PDF]

, 2022
Julie Van Coillie, Tamás Pongrácz, Johann Rahmöller, Hung‐Jen Chen, Chiara E. Geyer, Lonneke A. van Vlught, Jana Sophia Buhre, Tonći Šuštić, Thijs L. J. van Osch, Maurice Steenhuis, Willianne Hoepel, Wenjun Wang, Anne S. Lixenfeld, Jan Nouta, Sofie Keijzer, Federica Linty, Remco Visser, Mads Delbo Larsen, Emily Martin, Inga Künsting, Selina Lehrian, Vera von Kopylow, Carsten Kern, Hanna B. Lunding, Menno P.J. de Winther, Niels van Mourik, Theo Rispens, Tobias Graf, Marleen A. Slim, René Minnaar, Marije K. Bomers, Jonne J. Sikkens, Alexander P. J. Vlaar, C. Ellen van der Schoot, Jeroen den Dunnen, Manfred Wuhrer, Marc Ehlers, Gestur Vidarsson, the Fatebenefratelli-Sacco Infectious Diseases Physicians group and UMC COVID-19 S3/HCW study group   +38 more
openalex   +1 more source