Results 101 to 110 of about 368,728 (306)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Tumor antigen cross-presentation and the dendritic cell: Where it all begins?

, 2010
Dendritic cells (DCs) are professional antigen-presenting cells (APCs) that are critical for the generation of effective cytotoxic T lymphocyte (CTL) responses; however, their function and phenotype are often defective or altered in tumor-bearing hosts ...
McDonnell, A.M., Robinson, B.W.S., Currie, A.J.   +2 more
core  

In vitro characterization of immune-related properties of human fetal bone cells for potential tissue engineering applications [PDF]

, 2009
We describe herein some immunological properties of human fetal bone cells recently tested for bone tissue-engineering applications. Adult mesenchymal stem cells (MSCs) and osteoblasts were included in the study for comparison.
Martin, I, Arnaud Scherberich, Montjovent, MO, Scherberich, A, Scherberich, Arnaud, Lee Ann Applegate, Montjovent, Marc-Olivier, Marc-Olivier Montjovent, Scaletta, Corinne, Dominique P. Pioletti, Bocelli-Tyndall, Chiara, Martin, Ivan, Applegate, LA, Laurent-Applegate, Lee, Bocelli-Tyndall, C., Pioletti, DP, Scherberich, A., Silke Mark, Montjovent, M.O., Scaletta, C, Pioletti, Dominique P., Mark, Silke, Mark, S., Bocelli-Tyndall, C, Applegate, Lee Ann, Mark, S, Pioletti, D.P., Corinne Scaletta, Scaletta, C., Ivan Martin, Martin, I., Applegate, L.A., Chiara Bocelli-Tyndall   +32 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Physiological and therapeutic relevance of T cell receptor-mediated antigen trogocytosis

Biomedical Journal
Trogocytosis is an active process whereby fragments of plasma membrane proteins and cytoplasm are transferred from one cell to another in a cell-cell contact-dependent manner. T cells trogocytose pieces of the cells presenting antigen to them at the site
Nuria Martinez-Martin, Balbino Alarcon
doaj   +1 more source

Porcine NK Cells Stimulate Proliferation of Pseudorabies Virus-Experienced CD8+ and CD4+CD8+ T Cells

Frontiers in Immunology, 2019
Natural killer (NK) cells belong to the innate immune system and play a central role in the defense against viral infections and cancer development, but also contribute to shaping adaptive immune responses.
Steffi De Pelsmaeker, Bert Devriendt, Nick De Regge, Herman W. Favoreel   +3 more
doaj   +1 more source

The inhibitory receptor LILRB4 (ILT3) modulates antigen presenting cell phenotype and, along with LILRB2 (ILT4), is upregulated in response to Salmonella infection.

, 2009
BACKGROUND: Leukocyte Ig-like receptors (LILR) are a family of innate immune receptors with immunomodulatory functions. High-level expression of the receptors LILRB2 (ILT4) and LILRB4 (ILT3) is a feature of tolerogenic antigen presenting cells and has ...
Lapaque Nicolas, Brown Damien P, Buerki, RA, Allen, RL, Brown, DP, Trowsdale John, Allen Rachel L, Jones Des C, Anderson, KJ, Buerki Robin A, Jones, DC, Lapaque, N, Trowsdale, J, Anderson Katie J   +13 more
core   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

What lies beneath the airway mucosal barrier? Throwing the spotlight on antigen‐presenting cell function in the lower respiratory tract

Clinical & Translational Immunology, 2020
The global prevalence of respiratory infectious and inflammatory diseases remains a major public health concern. Prevention and management strategies have not kept pace with the increasing incidence of these diseases. The airway mucosa is the most common
Saparna Pai, Visai Muruganandah, Andreas Kupz   +2 more
doaj   +1 more source