Results 121 to 130 of about 19,444,475 (370)

A Novel Hybrid CNN-AIS Visual Pattern Recognition Engine

, 2015
Machine learning methods are used today for most recognition problems. Convolutional Neural Networks (CNN) have time and again proved successful for many image processing tasks primarily for their architecture.
A Borji, A Krizhevsky, E Hart, F Lauer, G Dudek, LN Castro De, N Pinto, S Knerr, T Serre, Y LeCun, Y Shao   +10 more
core   +1 more source

Bipartite regulation of different components of the MHC class I antigen-processing machinery during dendritic cell maturation [PDF]

, 2001
Jian Li, Beatrice Schuler‐Thurner, Gerold Schuler, C. Huber, Barbara Seliger   +4 more
openalex   +1 more source

Posttranscriptional regulation of the components of the human leukocyte antigen class I antigen processing and presentation machinery as an immune escape mechanism in melanoma

, 2021
Maria‐Filothei Lazaridou
openalex   +1 more source

Chitinase 3-like 1, Carcinoembryonic Antigen-related Cell Adhesion Molecule 6, and Ectopic Claudin-2 in the Carcinogenic Processes of Ulcerative Colitis [PDF]

, 2022
TETSUSHI KINUGASA, Toshiyuki Tsunoda, Emiko Mizoguchi, TOSHIYUKI OKADA, Tomoya Sudo, AKIHIKO KAWAHARA, Jun Akiba, Yoshito Akagi   +7 more
openalex   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

MHC-restricted antigen presentation and recognition: constraints on gene, recombinant and peptide vaccines in humans

Brazilian Journal of Medical and Biological Research, 1999
The target of any immunization is to activate and expand lymphocyte clones with the desired recognition specificity and the necessary effector functions.
Cunha-Neto E.
doaj  

Insulin-degrading enzyme regulates insulin-directed cellular autoimmunity in murine type 1 diabetes

Frontiers in Immunology
Type 1 diabetes results from the destruction of pancreatic beta cells by autoreactive T cells. As an autoantigen with extremely high expression in beta cells, insulin triggers and sustains the autoimmune CD4+ and CD8+ T cell responses and islet ...
Marie-Andrée Bessard, Anna Moser, Emmanuelle Waeckel-Énée, Vivian Lindo, Abdelaziz Gdoura, Sylvaine You, F. Susan Wong, Fiona Greer, Peter van Endert, Peter van Endert   +9 more
doaj   +1 more source

An Unexpected Major Role for Proteasome-Catalyzed Peptide Splicing in Generation of T Cell Epitopes: Is There Relevance for Vaccine Development?

Frontiers in Immunology, 2017
Efficient and safe induction of CD8+ T cell responses is a desired characteristic of vaccines against intracellular pathogens. To achieve this, a new generation of safe vaccines is being developed accommodating single, dominant antigens of pathogens of ...
Anouk C. M. Platteel, Juliane Liepe, Willem van Eden, Michele Mishto, Michele Mishto, Michele Mishto, Alice J. A. M. Sijts   +6 more
doaj   +1 more source

Membrane Topology of the Transporter Associated with Antigen Processing (TAP1) within an Assembled Functional Peptide-loading Complex [PDF]

, 2006
Susanne Schrodt, Joachim Koch, Robert Tampé   +2 more
openalex   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source