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Pathways of antigen processing
Current Opinion in Immunology, 1991Separate pathways exist for the processing of antigens to be presented by MHC class I and class II molecules. We are beginning to determine the subcellular location of certain events in both pathways.
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Viral effects on antigen processing
Current Opinion in Immunology, 1999Viruses have evolved numerous mechanisms that modulate MHC-mediated antigen presentation, which in turn protect infected cells from T-lymphocyte-mediated immunosurveillance. Recent studies of previously identified viral immunomodulatory proteins reveal the allelic specificity of these proteins, their ability to function in xenogeneic systems and the ...
D M, Miller, D D, Sedmak
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Antigen processing: an interim report
Trends in Biochemical Sciences, 1988Abstract The activation of B cells to synthesize and secrete antibody requires, in the vast majority of cases, the coincident activation of antigen-specific helper T cells to release B-cell growth and differentiation factors. Unlike antibody, which constitutes the B-cell receptor, the T-cell receptor does not bind globular protein antigens in their ...
S K, Pierce, E, Margoliash
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Antigen processing by the proteasome
Nature Reviews Molecular Cell Biology, 2001The proteasome is an essential part of our immune surveillance mechanisms: by generating peptides from intracellular antigens it provides peptides that are then 'presented' to T cells. But proteasomes--the waste-disposal units of the cell--typically do not generate peptides for antigen presentation with high efficiency.
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Antigen Processing/Presenting and Oncogenesis
Critical Reviews™ in Oncogenesis, 1997It has been established in recent years that a number of tumor cell types express tumor antigens, yet the host's immune system fails to recognize them. The antigen processing/presenting machinery, which plays a crucial role in generating an immune response, and possible causes for its inability of processing/presenting tumor antigens are reviewed ...
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Antigen processing movers and shakers
Nature Chemical Biology, 2018Monitoring MHC-I dynamics upon binding to its chaperone TAPBPR helps us understand how optimal peptide sequences are selected for presentation and coordinated with release of the chaperone from the ternary peptide–MHC-I–TAPBPR complex.
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Editorial overview: Antigen processing
Current Opinion in Immunology, 2016Christopher C, Norbury +1 more
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