Results 231 to 240 of about 3,934,806 (290)

A guide to antigen processing and presentation

Nature Reviews Immunology, 2022
Antigen processing and presentation are the cornerstones of adaptive immunity. B cells cannot generate high-affinity antibodies without T cell help. CD4+ T cells, which provide such help, use antigen-specific receptors that recognize major histocompatibility complex (MHC) molecules in complex with peptide cargo. Similarly, eradication of virus-infected
Hidde Ploegh, Thibault Harmand, Novalia Pishesha   +2 more
exaly   +3 more sources

Antigen processing in earthworms

Immunology Letters, 1994
The administration of protein antigens into earthworms Lumbricus terrestris and Eisenia foetida induces the formation of antigen-binding protein (ABP) with the maximum response occurring between days 4 and 8. High proteolytic activities observed both in coelomocytes and in coelomic fluids cause rapid antigen degradation; the majority of antigen is ...
L, Tucková, M, Bilej
openaire   +2 more sources

Antigen processing and presentation

2019
Dendritic cells are at the center of immune responses. They are defined by their ability to sense the environment, take up and process antigen, migrate to secondary lymphoid organs, where they present antigens to the adaptive immune system. In particular, they present lipids and proteins from pathogens, which they encountered in peripheral tissues, to ...
Kotsias, Fiorella, Cebrián, José Ignacio, Alloatti, Andrés   +2 more
openaire   +3 more sources

Mechanisms of Antigen Processing

Immunological Reviews, 1988
Using MAb and monovalent Fab probes and saponin permeabilization we have demonstrated that PEC and TA3 B lymphoma-hybridoma cells contain a significant intracellular pool of Ia. At least in TA3 cells, this intracellular pool was independent of protein synthesis. In PEC, adherence caused redistribution of Ia with disappearance of the intracellular pool.
C V, Harding, F, Leyva-Cobian, E R, Unanue   +2 more
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Antigen processing by the proteasome

Nature Reviews Molecular Cell Biology, 2001
The proteasome is an essential part of our immune surveillance mechanisms: by generating peptides from intracellular antigens it provides peptides that are then 'presented' to T cells. But proteasomes--the waste-disposal units of the cell--typically do not generate peptides for antigen presentation with high efficiency.
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Proteasomes and Antigen Processing

1997
Publisher Summary This chapter discusses the recent findings related to the roles of proteasomes in the major histocompatibility complex (MHC) class I-restricted antigen-processing pathway. One of the most important responses in this antigen-specific immune system is to distinguish correctly non-self-antigens from self-antigens for selective ...
K, Tanaka, N, Tanahashi, C, Tsurumi, K Y, Yokota, N, Shimbara   +4 more
openaire   +2 more sources

Antigen processing and presentation

Immunology Letters, 1990
An overview of the various aspects of antigen degradation and presentation is given with special emphasis on the possible occurrence of variation in the enzymatic machinery present in different cells or individuals. Different procedures for epitope mapping are also presented as well as the characterization of universal epitopes in humans.
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Pathways of antigen processing

Current Opinion in Immunology, 1991
Separate pathways exist for the processing of antigens to be presented by MHC class I and class II molecules. We are beginning to determine the subcellular location of certain events in both pathways.
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Endosomal proteases and antigen processing

Trends in Biochemical Sciences, 1997
T cells are activated by fragments of antigenic proteins bound to major histocompatibility complex (MHC) molecules and displayed on the cell surface. MHC class II proteins scavenge processed protein antigens from within endosomal compartments. The antigenic peptides are generated within these and other intracellular compartments using the array of ...
B, Fineschi, J, Miller
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Antigen presentation, antigen-presenting cells and antigen processing

Current Opinion in Immunology, 1988
To summarize, during the period under review there have been considerable advances in our understanding of how antigen is associated with MHC on the surface of a presenting cell. Basic rules which govern this association have been confirmed as including both the nature and the configuration of the antigen.
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