Lysosomes and lysosome‐related organelles in immune responses
FEBS Open Bio, 2022 The catabolic, degradative capacity of the endo‐lysosome system is put to good use in mammalian immune responses as is their recently established status as signaling platforms.
Colin Watts
doaj +1 more source
Making Insulin and Staying Out of Autoimmune Trouble: The Beta-Cell Conundrum
Frontiers in Immunology, 2021 Autoimmune type 1 diabetes (T1D) results from the intricate crosstalk of various immune cell types. CD8+ T cells dominate the pro-inflammatory milieu of islet infiltration (insulitis), and are considered as key effectors of beta-cell destruction, through
Alexia Carré +2 more
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Selection, transmission, and reversion of an antigen-processing cytotoxic T-lymphocyte escape mutation in Human Immunodeficiency Virus Type 1 infection [PDF]
, 2004 Numerous studies now support that human immunodeficiency virus type 1 (HIV-1) evolution is influenced by immune selection pressure, with population studies showing an association between specific HLA alleles and mutations within defined cytotoxic T ...
Allen, T.M. +19 more
core +2 more sources
Neo-Splicetopes in Tumor Therapy: A Lost Case?
Frontiers in Immunology, 2022 Proteasome generates spliced peptides by ligating two distant cleavage products in a reverse proteolysis reaction. The observation that CD8+ T cells recognizing a spliced peptide induced T cell rejection in a melanoma patient following adoptive T cell ...
Peter M. Kloetzel
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A novel HLA-B18 restricted CD8+ T cell epitope is efficiently cross-presented by dendritic cells from soluble tumor antigen [PDF]
, 2012 NY-ESO-1 has been a major target of many immunotherapy trials because it is expressed by various cancers and is highly immunogenic. In this study, we have identified a novel HLA-B*1801-restricted CD8<sup>+</sup>T cell epitope, NY-ESO-1<sub&
Ashley J. Knights +18 more
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CD4+ Th immunogenicity of the Ascaris spp. secreted products [PDF]
, 2020 Ascaris spp. is a major health problem of humans and animals alike, and understanding the immunogenicity of its antigens is required for developing urgently needed vaccines.
Bertazzon, Miriam +6 more
core +1 more source
An insight into the origin, distribution, and techniques of demonstration of Langerhans cells
SRM Journal of Research in Dental Sciences, 2017 Langerhans cells (LCs), first described by Paul Langerhans, a German physician in 1868, are dendritic cells predominantly observed in the suprabasal layers of the epidermis and the oral epithelium.
Sarangi Snehanjan, Aich Ritesh
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Can ERAP1 and ERAP2 Form Functional Heterodimers? A Structural Dynamics Investigation
Frontiers in Immunology, 2022 Endoplasmic reticulum aminopeptidases 1 and 2 (ERAP1 and ERAP2) play important roles in the generation of antigenic peptides presented by Major Histocompatibility Class I (MHCI) molecules and indirectly regulate adaptive immune responses.
Athanasios Papakyriakou +3 more
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Antigen-Specific Polyclonal Cytotoxic T Lymphocytes Induced by Fusions of Dendritic Cells and Tumor Cells [PDF]
, 2010 The aim of cancer vaccines is induction of tumor-specific cytotoxic T lymphocytes (CTLs) that can reduce the tumor mass. Dendritic cells (DCs) are potent antigen-presenting cells and play a central role in the initiation and regulation of primary immune ...
Gong, Jianlin +6 more
core +5 more sources
HLA class II antigen-processing pathway in tumors: Molecular defects and clinical relevance
Oncoimmunology, 2017 The human leukocyte antigen (HLA) class II antigen-processing machinery (APM) presents to cognate CD4+ T-cells antigenic peptides mainly generated from exogeneous proteins in the endocytic compartment.
B. Seliger, M. Kloor, S. Ferrone
semanticscholar +1 more source