Results 51 to 60 of about 19,444,475 (370)

Inhibiting DNA methylation activates cancer testis antigens and expression of the antigen processing and presentation machinery in colon and ovarian cancer cells

PLoS ONE, 2017
Innovative therapies for solid tumors are urgently needed. Recently, therapies that harness the host immune system to fight cancer cells have successfully treated a subset of patients with solid tumors.
C. Siebenkäs, Katherine B. Chiappinelli, Angela A. Guzzetta, A. Sharma, J. Jeschke, Rajita Vatapalli, S. Baylin, N. Ahuja   +7 more
semanticscholar   +1 more source

TAPBPR mediates peptide dissociation from MHC class I using a leucine lever

eLife, 2018
Tapasin and TAPBPR are known to perform peptide editing on major histocompatibility complex class I (MHC I) molecules; however, the precise molecular mechanism(s) involved in this process remain largely enigmatic.
F Tudor Ilca, Andreas Neerincx, Clemens Hermann, Ana Marcu, Stefan Stevanović, Janet E Deane, Louise H Boyle   +6 more
doaj   +1 more source

Class-switched anti-insulin antibodies originate from unconventional antigen presentation in multiple lymphoid sites [PDF]

, 2016
Autoantibodies to insulin are a harbinger of autoimmunity in type 1 diabetes in humans and in non-obese diabetic mice. To understand the genesis of these autoantibodies, we investigated the interactions of insulin-specific T and B lymphocytes using T ...
Acevedo-Suárez, Achenbach, Adelstein, Akashi, Batista, Bodansky, Cooke, Crotty, Dean, Emil R. Unanue, Ferris, Gagnerault, Garside, Gitlin, Glazier, Goodnow, Greeley, Gretz, Harbers, Henry, Henry, Henry-Bonami, Hoppu, Hu, Hulbert, Höglund, James W. Thomas, Kendall, Kendall, Kenefeck, Levisetti, Linterman, Mariño, Mohan, Mohan, Mohan, Nakayama, Noorchashm, Okada, Pape, Rasio, Reinhardt, Rojas, Roozendaal, Serreze, Silva, Takahashi, Ueno, Unanue, Victora, Victora, Vinuesa, Vomund, Williams, Xiaoxiao Wan, Yang, Zhang, Zhang, Zikherman, Zotos   +59 more
core   +2 more sources

Genetics of antigen processing and presentation

Immunogenetics, 2018
Immune response to disease requires coordinated expression of an army of molecules. The highly polymorphic MHC class I and class II molecules are key to control of specificity of antigen presentation.
A. Kelly, J. Trowsdale
semanticscholar   +1 more source

A loop structure allows TAPBPR to exert its dual function as MHC I chaperone and peptide editor

eLife, 2020
Adaptive immunity vitally depends on major histocompatibility complex class I (MHC I) molecules loaded with peptides. Selective loading of peptides onto MHC I, referred to as peptide editing, is catalyzed by tapasin and the tapasin-related TAPBPR.
Lina Sagert, Felix Hennig, Christoph Thomas, Robert Tampé   +3 more
doaj   +1 more source

Generation of virus-specific cytotoxic T cells in vitro II. Induction requirements with functionally inactivated virus preparations [PDF]

, 1980
Using noninfectious Sendai virus preparations after selective enzymatic digestion of either of the two viral envelope glycoproteins, it was possible to study the effect of different virion-cell membrane interactions on virus-specific cytotoxic T ...
Bosslet, Braciale, Ennis, Ertl, Ertl, Finberg, Gething, Halloran, Hapel, Homma, Hosaka, Julius, Klenk, Koszinowski, Koszinowski, Koszinowski, Levy, Palmer, Pfitzenmaier, Rosenthal, Scheid, Schrader, Shimizu, Sugamura, Sugamura, Wiktor, Zinkernagel, Zweerink   +27 more
core   +1 more source

Immunochromatographic diagnostic test analysis using Google Glass. [PDF]

, 2014
We demonstrate a Google Glass-based rapid diagnostic test (RDT) reader platform capable of qualitative and quantitative measurements of various lateral flow immunochromatographic assays and similar biomedical diagnostics tests.
Caire, Romain, Cortazar, Bingen, Feng, Steve, Ozcan, Aydogan, Turan, Mehmet, Wong, Andrew   +5 more
core   +1 more source

The crosstalk between autophagic and endo-/exosomal pathways in antigen processing for MHC presentation in anticancer T cell immune responses

Journal of Hematology & Oncology, 2017
T cells recognize antigen fragments from proteolytic products that are presented to them in the form of peptides on major histocompatibility complex (MHC) molecules, which is crucial for the T cell to identify infected or transformed cells.
L. You, Li-ping Mao, Juying Wei, Shenhe Jin, Chunmei Yang, Hui Liu, Li Zhu, W. Qian   +7 more
semanticscholar   +1 more source

Cross-presentation of cell-associated antigens by mouse splenic dendritic cell populations

Frontiers in Immunology, 2012
Cross-presentation of cell-associated antigens (Ag) plays an important role in the induction of anti-tumor responses, autoimmune diseases, and transplant rejection.
Edith M Janssen, Robert I Thacker
doaj   +1 more source

Epithelial-myeloid exchange of MHC class II constrains immunity and microbiota composition

Cell Reports, 2021
Summary: Intestinal epithelial cells (IECs) have long been understood to express high levels of major histocompatibility complex class II (MHC class II) molecules but are not considered canonical antigen-presenting cells, and the impact of IEC-MHC class ...
W. Zac Stephens, Jason L. Kubinak, Arevik Ghazaryan, Kaylyn M. Bauer, Rickesha Bell, Kate Buhrke, Tyson R. Chiaro, Allison M. Weis, William W. Tang, Josh K. Monts, Ray Soto, H. Atakan Ekiz, Ryan M. O’Connell, June L. Round   +13 more
doaj   +1 more source