Results 71 to 80 of about 4,134,311 (295)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Elucidation of the Signatures of Proteasome-Catalyzed Peptide Splicing

Frontiers in Immunology, 2020
Proteasomes catalyze the degradation of endogenous proteins into oligopeptides, but can concurrently create spliced oligopeptides through ligation of previously non-contiguous peptide fragments. Recent studies have uncovered a formerly unappreciated role
Wayne Paes, German Leonov, Thomas Partridge, Annalisa Nicastri, Nicola Ternette, Persephone Borrow   +5 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Autophagy proteins in antigen processing for presentation on MHC molecules

, 2016
Autophagy describes catabolic pathways that deliver cytoplasmic constituents for lysosomal degradation. Since major histocompatibility complex (MHC) molecules sample protein degradation products and present them to T cells for adaptive immunity, it is ...
Münz, Christian, Münz C
core   +1 more source

Antigen-presenting autoreactive B cells activate regulatory T cells and suppress autoimmune arthritis in mice.

, 2023
B cells undergo several rounds of selection to eliminate potentially pathogenic autoreactive clones, but in contrast to T cells, evidence of positive selection of autoreactive B cells remains moot. Using unique tetramers, we traced natural autoreactive B
Joanna Rorbach (549544), Pierre Sabatier (2927019), Manman Geng (9325429), Rikard Holmdahl (901), Christian Michel Beusch (19848522), Alexander Krämer (3470201), Jan Kihlberg (26018), Jingdian Zhang (5023262), Gonzalo Fernandez Lahore (19848510), Inger Gjertsson (118342), Ana Coelho (319593), Alf Kastbom (235178), Harald Burkhardt (23413), Nhu-Nguyen Do (1703605), Bingze Xu (360548), Yibo He (4805139), Laura Romero Castillo (23578429), Erik Lönnblom (525461), Johan Viljanen (2002006), Roman A Zubarev (23578432), Hassan Abolhassani (2287858), Zhongwei Xu (1491388), Amit Saxena (76487), Mike Aoun (8934542), Christopher Sjöwall (3374)   +24 more
core   +1 more source

TAPBPR mediates peptide dissociation from MHC class I using a leucine lever

eLife, 2018
Tapasin and TAPBPR are known to perform peptide editing on major histocompatibility complex class I (MHC I) molecules; however, the precise molecular mechanism(s) involved in this process remain largely enigmatic.
F Tudor Ilca, Andreas Neerincx, Clemens Hermann, Ana Marcu, Stefan Stevanović, Janet E Deane, Louise H Boyle   +6 more
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Tumor-Derived Microvesicles Enhance Cross-Processing Ability of Clinical Grade Dendritic Cells

Frontiers in Immunology, 2018
Tumor cells release extracellular microvesicles (MVs) in the microenvironment to deliver biological signals to neighboring cells as well as to cells in distant tissues.
Marco Dionisi, Claudia De Archangelis, Federico Battisti, Hassan Rahimi Koshkaki, Francesca Belleudi, Ilaria Grazia Zizzari, Ilary Ruscito, Ilary Ruscito, Christian Albano, Alessandra Di Filippo, Maria Rosaria Torrisi, Maria Rosaria Torrisi, Pierluigi Benedetti Panici, Chiara Napoletano, Marianna Nuti, Aurelia Rughetti   +15 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Processing of Antigenic Peptides by Aminopeptidases

Biological and Pharmaceutical Bulletin, 2004
Antigenic peptides presented to major histocompatibility complex (MHC) class I molecules are generated in the cytosol during degradation of cellular proteins by the ubiquitin-proteasome proteolytic pathway. Proteasome can generate N-extended precursors as well as final epitopes, and then the precursors are processed to mature epitopes by ...
Hattori, Akira, Tsujimoto, Masafumi
openaire   +3 more sources