Results 81 to 90 of about 4,134,311 (295)

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

The genes related to the antigen processing and presentation pathway.

, 2015
The genes related to the antigen processing and presentation pathway.
Kui Li (48173), Leilei Xin (664368), Siyuan Kong (664369), Shulin Yang (76751), Jihan Xia (664367), Yuanyuan Zhang (101797), Yaoxing Chen (664370)   +6 more
core   +1 more source

Cross-presentation of cell-associated antigens by mouse splenic dendritic cell populations

Frontiers in Immunology, 2012
Cross-presentation of cell-associated antigens (Ag) plays an important role in the induction of anti-tumor responses, autoimmune diseases, and transplant rejection.
Edith M Janssen, Robert I Thacker
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Antigen processing in the endocytic compartment

, 2001
Proteolysis generates the peptides that bind to class II MHC molecules and, by destruction of the invariant chain, prepares the class II MHC molecule for capture of those peptides.
Colin Watts, Watts, C.
core   +1 more source

Using the TAP Component of the Antigen-Processing Machinery as a Molecular Adjuvant. [PDF]

, 2005
We hypothesize that over-expression of transporters associated with antigen processing (TAP1 and TAP2), components of the major histocompatibility complex (MHC) class I antigen-processing pathway, enhances antigen-specific cytotoxic activity in response ...
Moise Alex, Alex Moise, Susan S Chen, Jefferies Wilfred A, Vitalis, Timothy Z., Zhang, Qian-Jin, Qian-Jin Zhang, Tian Mei Mei, Chen, Susan S., Genc Basha, Bok Choi, Kyung, Timothy Z Vitalis, Mei Mei Tian, Jeffries Andy, Vitalis Timothy Z, Zhang Qian-Jin, Chen Susan S, Jeffries, Andy, Tian, Mei Mei, Jefferies, Wilfred A., Judie Alimonti, Douglas Waterfield, Alimonti, Judie, Waterfield, Douglas, Basha, Genc, Moise, Alexander R., Tiong, Jacqueline, Basha Genc, Choi Kyung Bok, Kyung Bok Choi, Alimonti Judie, Waterfield Douglas, Wilfred A Jefferies, Tiong Jacqueline, Jacqueline Tiong, Andy Jeffries   +35 more
core   +2 more sources

Spatiotemporal proteolytic susceptibility of allergens: positive or negative effects on the allergic sensitization?

Frontiers in Allergy
From their expression in their respective allergenic source to their processing by antigen presenting cells, allergens continuously encounter proteases.
Alain Jacquet, Wai Tuck Soh, Wai Tuck Soh   +2 more
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Genetics of antigen processing and presentation.

, 2018
Immune response to disease requires coordinated expression of an army of molecules. The highly polymorphic MHC class I and class II molecules are key to control of specificity of antigen presentation.

core   +2 more sources

Distinct Intracellular Compartments Involved in Invariant Chain Degradation and Antigenic Peptide Loading of Major Histocompatibility Complex (MHC) Class II Molecules [PDF]

, 1997
Major histocompatibility complex (MHC) class II molecules are transported to intracellular MHC class II compartments via a transient association with the invariant chain (Ii).
Pieters, J., Watts, Colin, Knight, Andrew M., Colin Watts, Ferrari, Giorgio, Andrew M. Knight, Pieters, Jean, Ferrari, G., Watts, C., Jean Pieters, Giorgio Ferrari, Knight, A. M.   +11 more
core   +1 more source