Results 41 to 50 of about 90,622 (257)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Divergent virulence and serological profiles reveal pathogenic evolution within the Bandavirus genus

Virulence
Viruses within the Bandavirus genus (Phenuiviridae family), phylogenetically divided into SFTSV and Bhanja groups, pose public health risks through cross-species transmission.
Chenxuan Li, Shu Shen, Liyan Fu, Jun Ni, Jian Xiao, Jin Qian, Shengyao Chen, Yaohui Fang, Min Zhou, Fei Deng, Xiaoli Wu   +10 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Molecular and Antigenic Characterization of Avian H9N2 Viruses in Southern China

Microbiology Spectrum, 2022
The H9N2 subtype avian influenza virus (AIV) has become endemic in poultry globally; however due to its low pathogenicity, it is not under primary surveillance and control in many countries.
Wanwan Yan, Hongrui Cui, Marc Engelsma, Nancy Beerens, Monique M. van Oers, Mart C. M. de Jong, Xuesong Li, Qinfang Liu, Jianmei Yang, Qiaoyang Teng, Zejun Li   +10 more
doaj   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Immunobiological Properties of Antigenic Preparations Streptococcus pneumoniae and their Mixtures

Эпидемиология и вакцинопрофилактика, 2022
Relevance. Type-specific immunity does not protect against infection with other pneumococcal serotypes. The phenomenon of the change of serotypes dominating the population of Streptococcus pneumoniae is known, in part due to the intensive recombination ...
M. M. Tokarskaya, E. A. Nayаnova, O. V. Nechaeva, S. A. Baranovskaya, O. M. Afanacyeva, D. S. Vorobyev, I. M. Gruber, E. A. Astashkina, N. N. Ovechko, I. B. Semenova, N. E. Yastrebova   +10 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Epidemic season 2023–2024: the palette of ARVI pathogens in some territories of the Russian Federation and WHO regions

Вопросы вирусологии
The purpose of this work was to determine the characteristics of the circulation of acute respiratory viral infection (ARVI) pathogens during the epidemic season of 2023–2024 in the WHO regions and Russian Federation. Materials and methods.
Elena I. Burtseva, Nataliya V. Breslav, Evgenia A. Mukasheva, Kirill G. Krasnoslobodtsev, Elena S. Kirillova, Svetlana V. Trushakova, Irina A. Komarova, Elena L. Feodoritova, Anna D. Panova, Lidiya B. Kisteneva, Irina N. Khlopova, Irina S. Kruzhkova, Anastasia S. Krepkaia, Ekaterina O. Morozova, Anna V. Ignatieva, Andrey B. Komissarov, Igor N. Tyurin, Aleksey A. Samkov, Nataliya A. Antipjat   +18 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source