Results 51 to 60 of about 126,752 (271)

Gene Silencing and Antigenic Variation in Malaria Parasites

The Scientific World Journal, 2001
Malaria remains one of the most important infectious diseases in the world today, infecting 300 to 500 million people yearly and resulting in 1 to 2 million deaths, primarily of young African children[1]. The most severe form of this disease is caused by
Kirk W. Deitsch
doaj   +1 more source

Sequence variation in the haemagglutinin-neuraminidase gene of human parainfluenza virus type 3 isolates in the UK [PDF]

, 1995
The sequence variation in a 934 base-pair region of the gene encoding the haemagglutinin-neuraminidase of five human parainfluenza virus type 3 (HPIV3) isolates was determined together with that of a prototype UK strain. All of the clinical isolates were
A. J. Easton, Cane, Colman, Elango, K. R. Collins, Sambrook, van Wyke Coelingh   +6 more
core   +2 more sources

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Analysis of symmetries in models of multi-strain infections [PDF]

, 2013
In mathematical studies of the dynamics of multi-strain diseases caused by antigenically diverse pathogens, there is a substantial interest in analytical insights.
A Fässler, A Sasaki, AL Lloyd, B Adams, B Adams, B Fiedler, BS Chan, C Castillo-Chavez, CA Pinto, CO Buckee, CO Buckee, D Earn, DG Aronson, DJ Gubler, DJ Smith, DJ Smith, EH Elbasha, H Farkas, I Melbourne, I Stewart, J Arino, J Cisternas, J Lin, JD Murray, JHP Dawes, JR Gog, JR Gog, JW Swift, K Koelle, KB Blyuss, KB Blyuss, KB Blyuss, KB Blyuss, Konstantin B. Blyuss, M Dellnitz, M Golubitsky, M Golubitsky, M Golubitsky, M Golubitsky, M Lipsitch, M Recker, M Recker, M Recker, M Recker, MGM Gomes, N Ferguson, NM Ferguson, P Minaev, P Rohani, P-L Buono, PG Smith, S Cobey, S Gupta, S Gupta, S Gupta, S Gupta, S Kryazhimsky, SA Levin, SB Halstead, V Andreasen, V Andreasen, V Calvez, V Gupta, Y Jiang   +63 more
core   +2 more sources

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Natural selection promotes antigenic evolvability. [PDF]

PLoS Pathogens, 2013
The hypothesis that evolvability - the capacity to evolve by natural selection - is itself the object of natural selection is highly intriguing but remains controversial due in large part to a paucity of direct experimental evidence.
Christopher J Graves, Vera I D Ros, Brian Stevenson, Paul D Sniegowski, Dustin Brisson   +4 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Highly Variable Expression of Merozoite Surface Protein MSPDBL2 in Diverse Plasmodium falciparum Clinical Isolates and Transcriptome Scans for Correlating Genes

mBio, 2022
The merozoite surface protein MSPDBL2 of Plasmodium falciparum is under strong balancing selection and is a target of naturally acquired antibodies. Remarkably, MSPDBL2 is expressed in only a minority of mature schizonts of any cultured parasite line ...
Suzanne E. Hocking, Lindsay B. Stewart, Aline Freville, Adam J. Reid, Sarah J. Tarr, Kevin K. A. Tetteh, Christian Flueck, Ambroise D. Ahouidi, Alfred Amambua-Ngwa, Mahamadou Diakite, Gordon A. Awandare, David J. Conway   +11 more
doaj   +1 more source

New methods for analyzing serological data with applications to influenza surveillance [PDF]

, 2009
Two important challenges to the use of serological assays for influenza surveillance include the substantial amount of experimental effort involved, and the inherent noisiness of serological data.
Wilfred Ndifon
core   +1 more source

Beyond immune escape:a variant surface glycoprotein causes suramin resistance in Trypanosoma brucei [PDF]

, 2017
Suramin is one of the first drugs developed in a medicinal chemistry program (Bayer, 1916), and it is still the treatment of choice for the hemolymphatic stage of African sleeping sickness caused by Trypanosoma brucei rhodesiense.
Cal, Monica, Graf, Fabrice E., Kunz Renggli, Christina, Mäser, Pascal, Ndomba, Emiliana, Schmidt, Remo S., Wenzler, Tanja, Wiedemar, Natalie, Zwyer, Michaela   +8 more
core   +3 more sources