Results 11 to 20 of about 2,347,137 (336)

Comprehensive antigen screening identifies Moraxella catarrhalis proteins that induce protection in a mouse pulmonary clearance model. [PDF]

PLoS ONE, 2013
Moraxella catarrhalis is one of the three most common causative bacterial pathogens of otitis media, however no effective vaccine against M. catarrhalis has been developed so far. To identify M.
Margarita Smidt, Patrick Bättig, Suzanne J C Verhaegh, Axel Niebisch, Markus Hanner, Sanja Selak, Wolfgang Schüler, Eva Morfeldt, Christel Hellberg, Eszter Nagy, Urban Lundberg, John P Hays, Andreas Meinke, Birgitta Henriques-Normark   +13 more
doaj   +1 more source

Vaxign-ML: supervised machine learning reverse vaccinology model for improved prediction of bacterial protective antigens

Bioinform., 2020
MOTIVATION Reverse vaccinology (RV) is a milestone in rational vaccine design, and machine learning (ML) has been applied to enhance the accuracy of RV prediction.
Edison Ong, Haihe Wang, Mei U Wong, Meenakshi Seetharaman, Ninotchka Valdez, Y. He   +5 more
semanticscholar   +1 more source

Nanocarriers based on bacterial membrane materials for cancer vaccine delivery

Nature Protocols, 2022
Here we present a protocol for the construction and use of two types of nanocarrier based on bacterial membrane materials for cancer vaccine delivery. Cancer vaccines induce tumor regression through triggering the specific T-cell responses against tumor ...
Xiao Zhao, Ruifang Zhao, Guangjun Nie
semanticscholar   +1 more source

Serological Test to Determine Exposure to SARS-CoV-2: ELISA Based on the Receptor-Binding Domain of the Spike Protein (S-RBD_N318-V510) Expressed in Escherichia coli

Diagnostics, 2021
Massive worldwide serological testing for SARS-CoV-2 is needed to determine the extent of virus exposure in a particular region, the ratio of symptomatic to asymptomatic infected persons, and the duration and extent of immunity after infection.
Alan Roberto Márquez-Ipiña, Everardo González-González, Iram Pablo Rodríguez-Sánchez, Itzel Montserrat Lara-Mayorga, Luis Alberto Mejía-Manzano, Mónica Gabriela Sánchez-Salazar, José Guillermo González-Valdez, Rocio Ortiz-López, Augusto Rojas-Martínez, Grissel Trujillo-de Santiago, Mario Moisés Alvarez   +10 more
doaj   +1 more source

Understanding GroEL and DnaK Stress Response Proteins as Antigens for Bacterial Diseases

Vaccines, 2020
Bacteria do not simply express a constitutive panel of proteins but they instead undergo dynamic changes in their protein repertoire in response to changes in nutritional status and when exposed to different environments.
K. R. Fourie, H. Wilson
semanticscholar   +1 more source

Sex and Gender Differences in Bacterial Infections

Infection and Immunity, 2022
There is a growing awareness of the importance of sex and gender in medicine and research. Women typically have stronger immune responses to self and foreign antigens than men, resulting in sex-based differences in autoimmunity and infectious diseases ...
S. Dias, M. Brouwer, D. van de Beek
semanticscholar   +1 more source

CAR T cells expressing a bacterial virulence factor trigger potent bystander antitumour responses in solid cancers

Nature Biomedical Engineering, 2022
Chimeric antigen receptor T cells (CAR T cells) are effective against haematologic malignancies. However, in solid tumours, their potency is hampered by local immunosuppression and by the heterogeneous expression of the antigen that the CAR targets. Here
Chuan Jin, Jing Ma, Mohanraj Ramachandran, Di Yu, M. Essand   +4 more
semanticscholar   +1 more source

Sequential Vaccination With Heterologous Acinetobacter baumannii Strains Induces Broadly Reactive Antibody Responses

Frontiers in Immunology, 2021
Antibody therapy may be an alternative treatment option for infections caused by the multi-drug resistant (MDR) bacterium Acinetobacter baumannii. As A.
Gathoni Kamuyu, Yat Suen Cheng, Sam Willcocks, Chidchamai Kewcharoenwong, Pattarachai Kiratisin, Peter W. Taylor, Brendan W. Wren, Ganjana Lertmemongkolchai, Ganjana Lertmemongkolchai, Richard A. Stabler, Jeremy Brown   +10 more
doaj   +1 more source

Vaccination Strategies Based on Bacterial Self-Assembling Proteins as Antigen Delivery Nanoscaffolds

Vaccines, 2022
Vaccination has saved billions of human lives and has considerably reduced the economic burden associated with pandemic and endemic infectious diseases.
Félix Lamontagne, Vinay Khatri, Philippe St-Louis, S. Bourgault, D. Archambault   +4 more
semanticscholar   +1 more source

Outer membrane vesicles: A bacterial-derived vaccination system

Frontiers in Microbiology, 2022
Outer membrane vesicles (OMVs) are non-living spherical nanostructures that derive from the cell envelope of Gram-negative bacteria. OMVs are important in bacterial pathogenesis, cell-to-cell communication, horizontal gene transfer, quorum sensing, and ...
Linda A. Lieberman
doaj   +1 more source