Results 11 to 20 of about 203,922 (264)

Sequential Vaccination With Heterologous Acinetobacter baumannii Strains Induces Broadly Reactive Antibody Responses

Frontiers in Immunology, 2021
Antibody therapy may be an alternative treatment option for infections caused by the multi-drug resistant (MDR) bacterium Acinetobacter baumannii. As A.
Gathoni Kamuyu, Yat Suen Cheng, Sam Willcocks, Chidchamai Kewcharoenwong, Pattarachai Kiratisin, Peter W. Taylor, Brendan W. Wren, Ganjana Lertmemongkolchai, Ganjana Lertmemongkolchai, Richard A. Stabler, Jeremy Brown   +10 more
doaj   +1 more source

Identification of Circulating Bacterial Antigens by In Vivo Microbial Antigen Discovery

mBio, 2011
Detection of microbial antigens in clinical samples can lead to rapid diagnosis of an infection and administration of appropriate therapeutics. A major barrier in diagnostics development is determining which of the potentially hundreds or thousands of ...
Dana E. Nuti, Reva B. Crump, Farida Dwi Handayani, Narisara Chantratita, Sharon J. Peacock, Richard Bowen, Philip L. Felgner, D. Huw Davies, Terry Wu, C. Rick Lyons, Paul J. Brett, Mary N. Burtnick, Thomas R. Kozel, David P. AuCoin   +13 more
doaj   +1 more source

Proteomics-identified Bvg-activated autotransporters protect against bordetella pertussis in a mouse model. [PDF]

PLoS ONE, 2014
Pertussis is a highly infectious respiratory disease of humans caused by the bacterium Bordetella pertussis. Despite high vaccination coverage, pertussis has re-emerged globally.
Daan de Gouw, Marien I de Jonge, Peter W M Hermans, Hans J C T Wessels, Aldert Zomer, Alinda Berends, Catherine Pratt, Guy A Berbers, Frits R Mooi, Dimitri A Diavatopoulos   +9 more
doaj   +1 more source

Outer membrane vesicles: A bacterial-derived vaccination system

Frontiers in Microbiology, 2022
Outer membrane vesicles (OMVs) are non-living spherical nanostructures that derive from the cell envelope of Gram-negative bacteria. OMVs are important in bacterial pathogenesis, cell-to-cell communication, horizontal gene transfer, quorum sensing, and ...
Linda A. Lieberman
doaj   +1 more source

Interferon-gamma-activated macrophages infected with Burkholderia cenocepacia process and present bacterial antigens to T-cells by class I and II major histocompatibility complex molecules

Emerging Microbes and Infections, 2020
Burkholderia cenocepacia is an emerging opportunistic pathogen for people with cystic fibrosis and chronic granulomatous disease. Intracellular survival in macrophages within a membrane-bound vacuole (BcCV) that delays acidification and maturation into ...
Roberto Rosales-Reyes, Paola Garza-Villafuerte, Daniela Vences-Vences, Daniel F. Aubert, Rubi Aca-Teutle, Vianney F. Ortiz-Navarrete, Laura C. Bonifaz, Julio Cesar Carrero-Sánchez, Alfonso Olivos-García, Miguel A. Valvano, José Ignacio Santos-Preciado   +10 more
doaj   +1 more source

Hybrid antigens expressing surface loops of BauA from Acinetobacter baumannii are capable of inducing protection against infection

Frontiers in Immunology, 2022
Acinetobacter baumannii is a human bacterial pathogen of increasing concern in clinical settings due to the emergence of antibiotic resistant strains and the lack of effective therapeutics.
Somshukla Chaudhuri, Iraj Rasooli, Ramin Hatefi Oskouei, Mahdi Pishgahi, Abolfazl Jahangir, Vahid Farshchi Andisi, Anthony B. Schryvers   +6 more
doaj   +1 more source

Bacterial Spore Antigens: a Review [PDF]

Journal of General Microbiology, 1962
SUMMARY: Agglutinogens and precipitinogens have been detected in the spores of many species of aerobic and anaerobic spore-formers and these antigens are distinct from those of the vegetative growth phases of the corresponding organisms. Spore antigens are heat resistant and antibody response is elicited by the injection of autoclaved spores into ...
openaire   +2 more sources

Synthetic carbohydrate-based vaccines: challenges and opportunities

Journal of Biomedical Science, 2020
Glycoconjugate vaccines based on bacterial capsular polysaccharides (CPS) have been extremely successful in preventing bacterial infections. The glycan antigens for the preparation of CPS based glycoconjugate vaccines are mainly obtained from bacterial ...
Ravinder Mettu, Chiang-Yun Chen, Chung-Yi Wu   +2 more
doaj   +1 more source

Molecular detection of enterotoxin genes (sea and sec) in Staphylococcus aureus isolated from dairy products in Karaj, Alborz, Iran

Studia Universitatis Babeș-Bolyai. Biologia
Staphylococcus aureus, a significant bacterial agent of food poisoning, particularly the strains producing enterotoxins, is a topic of paramount importance. The prevalence of these enterotoxins in the dairy industry, especially in regions like Karaj city,
Roudabeh Sadraie, Naser Harzandi, Bahman Tabaraei   +2 more
doaj   +1 more source

Outer membrane protein size and LPS O-antigen define protective antibody targeting to the Salmonella surface

Nature Communications, 2020
The O-antigen of LPS is known to limit the binding of antibody to bacterial surface antigens. Here the AUs show that the chemical and physical structure of the O-antigen are central factors in limiting the exposure of surface antigens to antibodies ...
C. Coral Domínguez-Medina, Marisol Pérez-Toledo, Anna E. Schager, Jennifer L. Marshall, Charlotte N. Cook, Saeeda Bobat, Hyea Hwang, Byeong Jae Chun, Erin Logan, Jack A. Bryant, Will M. Channell, Faye C. Morris, Sian E. Jossi, Areej Alshayea, Amanda E. Rossiter, Paul A. Barrow, William G. Horsnell, Calman A. MacLennan, Ian R. Henderson, Jeremy H. Lakey, James C. Gumbart, Constantino López-Macías, Vassiliy N. Bavro, Adam F. Cunningham   +23 more
doaj   +1 more source