Results 11 to 20 of about 1,199,934 (306)
High-throughput antigen discovery using Functional Genomic Vaccinology (FGV) identifies protective Streptococcus pneumoniae vaccine candidates [PDF]
Nature CommunicationsThe discovery of protective antigens remains a major bottleneck in bacterial vaccine development. To overcome this limitation, we present Functional Genomic Vaccinology (FGV), a high-throughput antigen discovery platform integrating genome-wide antigen ...
Giuseppe Ercoli +13 more
doaj +2 more sources
Bacterial outer membrane vesicles and vaccine applications [PDF]
, 2014 Vaccines based on outer membrane vesicles (OMV) were developed more than 20 years ago against Neisseria meningitidis serogroup B. These nano-sized structures exhibit remarkable potential for immunomodulation of immune responses and delivery of “self ...
Sarmiento, Maria Elena +10 more
core +4 more sources
Phenotypic and genotypic characterization of locally isolated Salmonella strains used in preparation of Salmonella antigens in Egypt [PDF]
Veterinary World, 2016 Aim: This work was conducted to study the phenotypic and genotypic characterization of locally isolated Salmonella strains (Salmonella Pullorum, Salmonella Enteritidis, and Salmonella Typhimurium) from poultry used in the preparation of Salmonella ...
Hazem Mohammed Ibrahim +3 more
doaj +1 more source
Glycosylation of bacterial antigens changes epitope patterns
Frontiers in Immunology, 2023 IntroductionUnlike glycosylation of proteins expressed in mammalian systems, bacterial glycosylation is often neglected in the development of recombinant vaccines.MethodsHere, we compared the effects of glycosylation of YghJ, an Escherichia coli protein ...
Karolin Kern +17 more
doaj +1 more source
Polysaccharide Vaccines: A Perspective on Non-Typhoidal Salmonella
Polysaccharides, 2021 Polysaccharides are often the most abundant antigens found on the extracellular surfaces of bacterial cells. These polysaccharides play key roles in interactions with the outside world, and for many bacterial pathogens, they represent what is presented ...
Sumudu R. Perera +2 more
doaj +1 more source
Comprehensive antigen screening identifies Moraxella catarrhalis proteins that induce protection in a mouse pulmonary clearance model. [PDF]
PLoS ONE, 2013 Moraxella catarrhalis is one of the three most common causative bacterial pathogens of otitis media, however no effective vaccine against M. catarrhalis has been developed so far. To identify M.
Margarita Smidt +13 more
doaj +1 more source
Vaccines, 2020 This study was designed to evaluate the immunogenicity and protective efficacy of two VP1 chimeric antigens of bacterial ghosts. Inoculation of the two VP1 chimeric antigens of bacterial ghosts into BALB/c mice markedly elicited humoral and mucosal ...
Saisai Gong +11 more
doaj +1 more source
Antigenic Variation in Bacterial Pathogens [PDF]
Microbiology Spectrum, 2016 ABSTRACT Antigenic variation is a strategy used by a broad diversity of microbial pathogens to persist within the mammalian host. Whereas viruses make use of a minimal proofreading capacity combined with large amounts of progeny to use random mutation for variant generation, antigenically variant bacteria have evolved mechanisms ...
Palmer, Guy H +2 more
openaire +3 more sources
Diagnostics, 2021 Massive worldwide serological testing for SARS-CoV-2 is needed to determine the extent of virus exposure in a particular region, the ratio of symptomatic to asymptomatic infected persons, and the duration and extent of immunity after infection.
Alan Roberto Márquez-Ipiña +10 more
doaj +1 more source
Journal of Patient-Centered Research and Reviews, 2020 Purpose: Legionella pneumophila pneumonia is a life-threatening, environmentally acquired infection identifiable via Legionella urine antigen tests (LUAT).
Caroline P. Toberna +4 more
doaj +1 more source