Results 121 to 130 of about 50,442 (246)

Regulatory B cells in the central nervous system: From immune regulation to neuroprotection

Neuroprotection, EarlyView.
Neuroinflammatory mechanisms and the therapeutic potential of regulatory B cells (Bregs). Following brain Injury (left panel) blood–brain barrier disruption facilitates the infiltration of peripheral leukocytes, including effector B cells (Beff) and effector T cells (Teff). This process triggers the activation of macrophages, astrocytes, and microglia,
Luiza Stanaszek, Miroslaw Janowski
wiley   +1 more source

Diagnosis and Management of Prenatal Hereditary Pyropoikilocytosis

Prenatal Diagnosis, EarlyView.
ABSTRACT Hereditary pyropoikilocytosis (HPP) is a severe hemolytic anemia caused by variants in SPTA1, SPTB, and EPB41. These weaken horizontal interactions in the erythrocyte cytoskeleton, causing membrane fragmentation and splenic sequestration. It will readily cause fetal anemia and often hydrops fetalis. Prenatal diagnosis requires first ruling out
Connor Hartzell, Samantha Stover, Nora Gibson, Timothy Olson, James Connelly, Matthew Grace, Jennifer Andrews   +6 more
wiley   +1 more source

Age‐related clinical heterogeneity and peripheral T cell profile alterations in primary Sjögren's disease: A retrospective study of 5778 patients

Rheumatology &Autoimmunity, EarlyView.
This large‐scale retrospective study of 5778 primary Sjögren's disease (SjD) patients, stratified by diagnostic age, defines a distinct clinical and immunological profile for early‐diagnosed (<45 years) disease. We identified early diagnosis as an independent risk factor for hypergammaglobulinemia and interstitial lung disease, underpinned by a ...
Yuan Ning, Ruiling Feng, Kai Zhang, Yipeng Han, Ruoyi Wang, Guangwen Li, Yuebo Jin, Jing He   +7 more
wiley   +1 more source

CAR T cell therapy in autoantibody-mediated neurological disorders: a promising strategy. [PDF]

J Neuroinflammation
Wen M, Zheng R, Zhang H, Goldberg SY, Jian Z, Gao Y, Cheng R, Wen L, Zhao Y, Kenderian SS, Shang P.   +10 more
europepmc   +1 more source

Development of a Novel Anti-CD19 Chimeric Antigen Receptor

Genetically modifying autologous T cells to express an anti-CD19 chimeric antigen receptor (CAR) has shown impressive response rates for the treatment of CD19+ B cell malignancies in several clinical trials (CTs). Making this treatment available to our patients prompted us to develop a novel CART19 based on our own anti-CD19 antibody (A3B1), followed ...
Castellà, Maria, Boronat, Anna||, Martín-Ibáñez, Raquel, Rodríguez, Vanina, Suñé, Guillermo||, Caballero, Miguel||, Marzal, Berta, Pérez-Amill, Lorena||, Martín-Antonio, B.||, Castaño Cardoso, Julio||, Bueno, Clara||, Balagué, Olga||, González-Navarro, Europa Azucena||, Serra-Pages, Carles, Engel, Pablo||, Vilella, Ramon, Benítez Ribas, Daniel||, Ortiz-Maldonado, Valentín||, Cid, Joan||, Tabera, Jaime||, Canals, Josep M.||, Lozano, Miquel||, Baumann, Tycho||, Vilarrodona, Anna||, Trias, Esteve||, Campo, Elias||, Menéndez Bujan, Pablo||, Urbano Ispizua, Álvaro||, Yagüe, Jordi||, Pérez-Galán, Patricia||, Rives, Susana||, Delgado, Julio||, Juan, Manel||   +32 more
openaire   +1 more source

Safe and Efficient CRISPR Genome Editing of Primary Human T Cells Using a Droplet‐Based Cell Mechanoporation Platform

Small, EarlyView.
This study introduces a microfluidic droplet mechanoporation system for the engineering of primary human T cells. The platform enables efficient, scalable, and robust delivery of mRNA for CAR T cell production and CRISPR‐Cas9 ribonucleoproteins for genome editing, while maintaining high cell viability.
You‐Jeong Kim, Sungwon Bang, Aram J. Chung   +2 more
wiley   +1 more source

Advances in Nanotechnology for Lymphoma Treatment: Targeted Delivery, Immunomodulation, and TME-Responsive Therapy Strategies. [PDF]

Int J Nanomedicine
Han B, Han Z, Zhang Y.
europepmc   +1 more source

169. Clinically Adaptable CD19-Specific Chimeric Antigen Receptor [PDF]

Molecular Therapy, 2014
openaire   +1 more source

Electronic health records improve the diagnosis and prognosis of pulmonary fungal infections in lung cancer patients

VIEW, EarlyView.
Pulmonary fungal infections are life‐threatening complications in lung cancer patients, posing significant challenges in clinical management. To address this, we developed machine learning tools that translate routine electronic health record data into actionable insights for diagnosing infections and assessing prognosis.
Hongwei Meng, Jiayun Yang, Shouzhi Yang, Ayizekeranmu Yiming, Wenjun Yu, Yuewei Zhao, Chunmeng Ding, Kexin Meng, Si Gao, Yang Li, Nan Dan, Dandan Feng, Yunhua Xu, Lin Huang, Yongxia Qiao   +14 more
wiley   +1 more source

From technological iteration to clinical breakthrough: advances of CAR-T cell therapy in autoimmune diseases. [PDF]

Ann Med
Yu B, Xu J, Cui Y.
europepmc   +1 more source