Results 131 to 140 of about 1,436,444 (347)

Anti-CD19 CAR-T cell therapy in relapsed/refractory t(8;21) acute myeloid leukemia with aberrant CD19 expression

Frontiers in Immunology
BackgroundT (8; 21) acute myeloid leukemia (AML) is a special type of acute leukemia, and exhibits a heterogeneous prognosis, with a long-term relapse rate of about 40%. Once t(8; 21) AML patients experience relapse, they have an extremely poor prognosis,
Xiaomin Zhang, Xiaomin Zhang, Lixin Wang, Jingqiao Qiao, Shuhong Wang, Lijun Wang, Lian Liu, Jiading Qin, Jiading Qin, Ziren Chen, Wenfa Huang, Yuanyuan Zheng, Huixin Peng, Junhui Mei, Hongxin Wang, Chuan Yu, Yisheng Li, Yisheng Li, Li Yu   +18 more
doaj   +1 more source

A new approach to gene therapy using Sleeping Beauty to genetically modify clinical-grade T cells to target CD19

Immunological Reviews, 2014
The advent of efficient approaches to the genetic modification of T cells has provided investigators with clinically appealing methods to improve the potency of tumor‐specific clinical grade T cells.
Harjeet Singh, H. Huls, P. Kebriaei, L. Cooper   +3 more
semanticscholar   +1 more source

Definition of Drosophila hemocyte subsets by cell-type specific antigens. [PDF]

, 2007
We analyzed the heterogeneity of Drosophila hemocytes on the basis of the expression of cell-type specific antigens. The antigens characterize distinct subsets which partially overlap with those defined by morphological criteria.
Laurinyecz, Barbara, Gateff, Elisabeth, Hultmark, Dan, Zsámboki, János, Andó, I., Váczi, Balázs, Vilmos, Péter, Zsámboki, J., Márkus, Róbert, Andó, István, Kurucz, Éva, Márkus, R., Hultmark, D., Vilmos, P., Csorba, Kinga, Váczi, B., Éva Kurucz, I. Andó, D. Hultmark, B. Váczi, Elisabeth Gateff, P. Vilmos, R. Márkus, Barbara Laurinyecz, Kinga Csorba, J. Zsámboki   +25 more
core   +1 more source

High‐Density Type I Collagen Promotes IFN‐γ+ CD8+ T Cell Exhaustion via SAT1‐ASS1‐Mediated Glutamine Accumulation and Ferroptosis in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
High‐density type I collagen promotes glutamine (Gln) accumulation–related ferroptosis of TNBC cells via the spermidine/spermine N1‐acetyltransferase 1 (SAT1)‐ argininosuccinate synthase (ASS1) signaling pathway, thus depriving immune cells of Gln supply and inducing IFN‐γ+ CD8+ T cell exhaustion in the TME.
Jinyan Wang, Shuangyue Pan, Lu Bai, Bin Li, Tiantian Liu, Jianing Cao, Mengdi Yang, Heda Zhang, Duancheng Guo, Wenxiang Zhi, Zhonghua Tao, Xichun Hu   +11 more
wiley   +1 more source

Expression of B-cell surface antigens in subpopulations of exosomes released from B-cell lymphoma cells.

Clinical Therapeutics, 2014
PURPOSE Exosomes are small (30- to 100-nm) vesicles secreted by all cell types in culture and found in most body fluids. A mean of 1 mL of blood serum, derived from healthy donors, contains approximately 10(12) exosomes.
M. Oksvold, A. Kullmann, L. Forfang, B. Kierulf, Mu Li, A. Brech, A. Vlassov, E. Smeland, Axl Neurauter, K. Pedersen   +9 more
semanticscholar   +1 more source

Single‐Cell Transcriptomic Profiling Identifies B Cell‐Intrinsic Dysregulation of Sphingolipid Biosynthesis and Could Be Improved by Inhibiting UGCG in Primary Immune Thrombocytopenia

Advanced Science, EarlyView.
This study generates the single‐cell atlas of pathogenic B‐cell subset Bc‐5 in ITP. It identifies RUNX3 as a key survival regulator and uncovers sphingolipid‐driven metabolic reprogramming, validating UGCG inhibition as a therapeutic candidate and building a valuable resource for ITP mechanistic and therapeutic exploration.
Dongmei Luo, Yanxia Zhan, Lili Ji, Pengcheng Xu, Pu Chen, Hao Pang, Yunan Ling, Fanli Hua, Xibing Zhuang, Hao Chen, Yunfeng Cheng   +10 more
wiley   +1 more source

A122

EJC Supplements, 2015
Tumor cells in chronic lymphocytic leukemia (CLL) usually have the “classic” immunophenotype CD19+, CD5+, CD23+, SmIgdim, CD20dim, FMC7-, CD79b-/dim, CD22-/dim.
S. Kolubaeva
doaj   +1 more source

Antigen-presentation of non-peptidic antigens lipid trafficking and loading [PDF]

, 2010
T cells recognize a broad variety of antigens, including peptides, lipids and non-peptidic phosphorylated metabolites. Clarification of the rules rendering non-peptidic molecules immunogenic is essential to understand and to influence the reactions of ...
Cavallari, Marco F.
core   +1 more source

T‐Cell Remodeling in Renal Fibrosis: From Acute Injury to Chronic Kidney Disease

Advanced Science, EarlyView.
This Review presents renal fibrosis as a sequence of overlapping T‐cell programs, from chemokine‐guided recruitment and metabolic activation to maladaptive polarization, tertiary lymphoid structure formation, tissue residency, exhaustion, and senescence.
Qianhui Li, Junting Guan, Yifan Song, Hongxia Yang, Guangtao Li, Xiaodong Zhao, Jiaxin Liu, Bin Liu, Yang Tan, Honglan Zhou, Yang‐He Zhang, Yishu Wang   +11 more
wiley   +1 more source

Decoding Biomolecular Phase Separation: From Physiological Roles to Pathological Mechanisms and Therapeutic Biomaterials Design

Advanced Science, EarlyView.
This review systematically elaborates on the mechanisms underlying physiological regulation and pathological dysregulation of biomolecular phase separation. It also summarizes advances in phase‑separation‑targeted therapeutic strategies and the design of functional biomaterials inspired by this process.
Jiawei Zhu, Jingbo Dong, Qiufang Gong, Xuejiao Song, Zhifa Shen, Chao Liang   +5 more
wiley   +1 more source