Results 121 to 130 of about 52,189 (266)

Diagnosis and Management of Prenatal Hereditary Pyropoikilocytosis

Prenatal Diagnosis, EarlyView.
ABSTRACT Hereditary pyropoikilocytosis (HPP) is a severe hemolytic anemia caused by variants in SPTA1, SPTB, and EPB41. These weaken horizontal interactions in the erythrocyte cytoskeleton, causing membrane fragmentation and splenic sequestration. It will readily cause fetal anemia and often hydrops fetalis. Prenatal diagnosis requires first ruling out
Connor Hartzell, Samantha Stover, Nora Gibson, Timothy Olson, James Connelly, Matthew Grace, Jennifer Andrews   +6 more
wiley   +1 more source

A Comprehensive Evaluation of CAR-T Cell Gene Therapy, Tracing its Revolutionary Clinical Breakthroughs and Advancements Towards Next-Generation Engineering. [PDF]

Expert Rev Mol Med
Aliciaslan M, Erbasan E, Sanlioglu S.
europepmc   +1 more source

Development of a Novel Anti-CD19 Chimeric Antigen Receptor

Genetically modifying autologous T cells to express an anti-CD19 chimeric antigen receptor (CAR) has shown impressive response rates for the treatment of CD19+ B cell malignancies in several clinical trials (CTs). Making this treatment available to our patients prompted us to develop a novel CART19 based on our own anti-CD19 antibody (A3B1), followed ...
Castellà, Maria, Boronat, Anna||, Martín-Ibáñez, Raquel, Rodríguez, Vanina, Suñé, Guillermo||, Caballero, Miguel||, Marzal, Berta, Pérez-Amill, Lorena||, Martín-Antonio, B.||, Castaño Cardoso, Julio||, Bueno, Clara||, Balagué, Olga||, González-Navarro, Europa Azucena||, Serra-Pages, Carles, Engel, Pablo||, Vilella, Ramon, Benítez Ribas, Daniel||, Ortiz-Maldonado, Valentín||, Cid, Joan||, Tabera, Jaime||, Canals, Josep M.||, Lozano, Miquel||, Baumann, Tycho||, Vilarrodona, Anna||, Trias, Esteve||, Campo, Elias||, Menéndez Bujan, Pablo||, Urbano Ispizua, Álvaro||, Yagüe, Jordi||, Pérez-Galán, Patricia||, Rives, Susana||, Delgado, Julio||, Juan, Manel||   +32 more
openaire   +1 more source

Long‐term outcomes of haploidentical hematopoietic stem cell transplantation with antithymocyte globulin–based myeloablative conditioning in pediatric refractory or relapsed non‐Hodgkin lymphoma

Pediatric Investigation, EarlyView.
Single‐center retrospective data showed that ATG‐based myeloablative haploidentical hematopoietic stem cell transplantation provides durable remission and favorable long‐term survival in children with refractory/relapsed non‐Hodgkin lymphoma, achieving high engraftment rates, low relapse incidence, and acceptable toxicity.
Chenguang Jia, Jie Zheng, Meng Yuan, Hongbo He, Yibo Fan, Bin Wang, Guanghua Zhu, Jun Yang, Yanhui Luo, Lixiao Cai, Pan Zhang, Yanlong Duan, Maoquan Qin   +12 more
wiley   +1 more source

Adapter-based allogeneic CAR T cells to overcome antigen escape in solid tumors. [PDF]

Front Immunol
Pham PQ, Sodji QH.
europepmc   +1 more source

Immunomodulatory Properties of Withania somnifera: Regulation of Innate Immune Cells and Clinical Implications

Phytotherapy Research, EarlyView.
ABSTRACT Withania somnifera (L.) Dunal (WS), commonly known as Ashwagandha, is a prominent medicinal herb in Ayurveda, with extensive therapeutic potential attributed to its diverse phytochemical profile. This review critically examines the immunomodulatory properties of WS, focusing on innate immune cell populations, including neutrophils, eosinophils,
Rana Yukta, Sonalika Gupta, Gagandeep Kaur, Partha Sarathi Mondal, Milirani Das, Anagha Ranade, Alok Kumar Srivastava, Sachin Kumar, Manoj Kumar Barthwal, Madhu Dikshit   +9 more
wiley   +1 more source

Emerging Applications of CAR-T Cell Therapy in Overcoming Resistance and Expanding Targets in Hematologic Malignancies: Insights from Recent Research. [PDF]

Curr Treat Options Oncol
Alipourfard I, Shafaghat Z, Saharkhiz S, Farani MR, Bakhtiyari S.   +4 more
europepmc   +1 more source

CD21 and CD19: how B cells sense antigen [PDF]

Clinical and Experimental Immunology, 1994
openaire   +1 more source

Age‐related clinical heterogeneity and peripheral T cell profile alterations in primary Sjögren's disease: A retrospective study of 5778 patients

Rheumatology &Autoimmunity, EarlyView.
This large‐scale retrospective study of 5778 primary Sjögren's disease (SjD) patients, stratified by diagnostic age, defines a distinct clinical and immunological profile for early‐diagnosed (<45 years) disease. We identified early diagnosis as an independent risk factor for hypergammaglobulinemia and interstitial lung disease, underpinned by a ...
Yuan Ning, Ruiling Feng, Kai Zhang, Yipeng Han, Ruoyi Wang, Guangwen Li, Yuebo Jin, Jing He   +7 more
wiley   +1 more source

Robust production of heavy-chain-only antibodies in mice by CRISPR/Cas mediated <i>in situ</i> modification of <i>IgH</i> locus. [PDF]

Natl Sci Rev
Wang W, Zheng S, Xiang G, Feng T, Peng Y, Wu Y, Du X, Zhu P, Ru Y, Zhang J, Wu S, Han H, Huang T, Cao G, Zheng H, Zhao Y, Wang H, Zhang R.   +17 more
europepmc   +1 more source