Results 41 to 50 of about 1,194,407 (281)

Antigen glycosylation regulates efficacy of CAR T cells targeting CD19 [PDF]

Nature Communications, 2022
AbstractWhile chimeric antigen receptor (CAR) T cells targeting CD19 can cure a subset of patients with B cell malignancies, most patients treated will not achieve durable remission. Identification of the mechanisms leading to failure is essential to broadening the efficacy of this promising platform.
Amanda Heard, Jack H. Landmann, Ava R. Hansen, Alkmini Papadopolou, Yu-Sung Hsu, Mehmet Emrah Selli, John M. Warrington, John Lattin, Jufang Chang, Helen Ha, Martina Haug-Kroeper, Balraj Doray, Saar Gill, Marco Ruella, Katharina E. Hayer, Matthew D. Weitzman, Abby M. Green, Regina Fluhrer, Nathan Singh   +18 more
openaire   +4 more sources

TriBAFF-CAR-T cells eliminate B-cell malignancies with BAFFR-expression and CD19 antigen loss

Cancer Cell International, 2021
Background To investigate the effect of TriBAFF-CAR-T cells on hematological tumor cells. Methods TriBAFF-CAR-T and CD19-CAR-T cells were co-cultured with BAFFR-bearing B-cell malignancies at different effector/target ratios to evaluate the anti-tumor ...
Guangchao Li, Qing Zhang, Zhi Liu, Huijuan Shen, Yangmin Zhu, Zhao Zhou, Wen Ding, Siqi Han, Jie Zhou, Ruiming Ou, Min Luo, Shuang Liu   +11 more
doaj   +1 more source

RELIABLE FLOW CYTOMETRY METHOD FOR MONITORING OF MINIMAL RESIDUAL DISEASE IN PATIENTS WITH B-CELL PRECURSOR ACUTE LYMPHOBLASTIC LEUKEMIA AFTER BLINATUMOMAB THERAPY

Hematology, Transfusion and Cell Therapy, 2023
Introduction: The recent active use of immunotherapy based on CD19/CD3 bispecific T-cell engager (blinatumomab), brings significant problems on monitoring Minimal Residual Disease (MRD) based on Multiparameter Flow Cytometry (MFC), due to possible CD19 ...
RM Pontes, FM Furtado, SCR Franco, RA Toscano, TF Nunes, ACS Dias, JCM Cordoba, ACMDS Junior, R Camargo, IMM Quezado   +9 more
doaj   +1 more source

Compromised antigen binding and signaling interfere with bispecific CD19 and CD79a chimeric antigen receptor function

Blood Advances, 2023
Abstract Therapy with CD19-directed chimeric antigen receptor (CAR) T cells has transformed the treatment of advanced B-cell malignancies. However, loss of or low antigen expression can enable tumor escape and limit the duration of responses achieved with CAR T-cell therapy. Engineering bispecific CAR T cells that target 2 tumor antigens
Isabel Leung, Megan L. Templeton, Yun Lo, Anusha Rajan, Sylvia M. Stull, Sarah M. Garrison, Alexander I. Salter, Kimberly S. Smythe, Colin E. Correnti, Shivani Srivastava, Cecilia C. S. Yeung, Stanley R. Riddell   +11 more
openaire   +2 more sources

Altered Phenotype and Enhanced Antibody-Producing Ability of Peripheral B Cells in Mice with Cd19-Driven Cre Expression

Cells, 2022
Given the importance of B lymphocytes in inflammation and immune defense against pathogens, mice transgenic for Cre under the control of Cd19 promoter (Cd19Cre/+ mice) have been widely used to specifically investigate the role of loxP-flanked genes in B ...
Ying Zhao, Sai Zhao, Xiao-Yuan Qin, Ting-Ting He, Miao-Miao Hu, Zheng Gong, Hong-Min Wang, Fang-Yuan Gong, Xiao-Ming Gao, Jun Wang   +9 more
doaj   +1 more source

Rejection of Experimental Hodgkins Lymphoma by T-cells Engineered with a CD19 Chimeric Antigen Receptor [PDF]

, 2012
T cells engineered to express chimeric receptors combining an external antibody binding domain with the CD3ζ T cell receptor (TCR) internal domain for triggering cell activation are being used for immunotherapeutic targeting of tumour cells in a non-HLA ...
Cheadle, Eleanor, Johannessen, Ingolfur, Talbot, Simon, Cheadle, Eleanor J, Crawford, Dorothy, Gilham, David, Gilham, David E, Johannessen, Ingo, Swanson, Anna   +8 more
core   +1 more source

Antigen-specific cytokine profiles for pulmonary Mycobacterium avium complex disease stage diagnosis

Frontiers in Immunology, 2023
IntroductionControlling pulmonary Mycobacterium avium complex (MAC) disease is difficult because there is no way to know the clinical stage accurately. There have been few attempts to use cell-mediated immunity for diagnosing the stage.
Yoshiro Yamashita, Yoshiro Yamashita, Ikkoh Yasuda, Ikkoh Yasuda, Takeshi Tanaka, Toru Ikeda, Mayumi Terada, Masahiro Takaki, Yoshiko Tsuchihashi, Norichika Asoh, Yukiko Ohara, Shymaa Enany, Shymaa Enany, Haruka Kobayashi, Sohkichi Matsumoto, Konosuke Morimoto, Konosuke Morimoto   +16 more
doaj   +1 more source

Immunotherapeutic potential of blinatumomab-secreting γ9δ2 T Cells

Translational Oncology, 2023
Previous studies have explored the use of engineered blinatumomab-secreting autologous αβ T cells for CD19-targeted cancer therapy. To create a more flexible allogeneic delivery system, we utilized γ9δ2 T cells rather than αβ T cells in a similar ...
Shang-Ju Wu, Chien-Ting Lin, Cheng Hao Liao, Chun-Ming Lin   +3 more
doaj   +1 more source

Natural Expression of the CD19 Antigen Impacts the Long-Term Engraftment but Not Antitumor Activity of CD19-Specific Engineered T Cells [PDF]

The Journal of Immunology, 2010
Abstract T cells gene-modified to express chimeric Ag receptors (CARs) have shown potent antitumor activity in vivo and are in clinical trials at locations worldwide. However, CAR activity has been investigated in mouse models in which Ag expression is restricted to the tumor.
Cheadle, Eleanor J., Hawkins, Robert E., Batha, Hayley, O'Neill, Allison L., Dovedi, Simon J., Gilham, David E.   +5 more
openaire   +2 more sources

Mesenchymal stem cells promote leukaemic cells aberrant phenotype from B-cell acute lymphoblastic leukaemia

Hematology/Oncology and Stem Cell Therapy, 2013
BACKGROUND AND OBJECTIVES: The role of bone marrow-mesenchymal stem cells (BM-MSC) in leukae-mic cell control is controversial. The purpose of this work was to evaluate BM-MSC role regarding the viability, proliferation and immunophenotype of normal B ...
Viviana M Rodríguez-Pardo, José A Aristizabal, Diana Jaimes, Sandra M Quijano, Iliana de los Reyes, María Victoria Herrera, Julio Solano, Jean Paul Vernot   +7 more
doaj   +1 more source