Results 191 to 200 of about 1,436,444 (347)

Chimeric antigen receptor T cell therapy in autoimmune neurological disease: current status of efficacy and safety. [PDF]

BMJ Neurol Open
Bradhurst P, Hardy TA, Riminton S.
europepmc   +1 more source

Clinical predictors of response to methotrexate in patients with rheumatoid arthritis: A systematic review

Rheumatology &Autoimmunity, EarlyView.
This review integrates clinical, immunological, genetic, and multi‐omic evidence, highlighting dynamic inflammatory and adenosine‐pathway biomarkers and reinforcing treat‐to‐target principles as the most actionable framework for personalized methotrexate therapy.
Joana Ramos Rodrigues, Helena Margarida de Miranda Lemos Romão Donato, Soraia Raquel Loureiro Azevedo, Luís Miguel da Silva Pires, Luís Pedro Bolotinha de Sousa Inês, Manuel Augusto Nunes Vicente Passos Morgado, Ana Filipa de Sousa Pestana Mourão   +6 more
wiley   +1 more source

Programmable CAR and antigen pairing for solid tumor immunotherapy. [PDF]

Mol Ther Oncol
Huang Z, Wang Y.
europepmc   +1 more source

Targeting the CD47–SIRPα phagocytic checkpoint in cancer: Biology, translational opportunities, and next‐generation therapeutic strategies

Smart Molecules, EarlyView.
The CD47–SIRPα axis has emerged as a critical innate immune checkpoint that suppresses macrophage‐mediated phagocytosis through a canonical “don't eat me” signal and enables tumor immune evasion. We comprehensively summarize the structural and biological features of CD47 and the molecular mechanisms underlying CD47‐mediated regulation of phagocytosis ...
Ruimei Zhou, Lingjie Jing, Jianping Zhang, Cheng Guo, Quanjun Yang   +4 more
wiley   +1 more source

Multi-antigen chimeric antigen receptor-T cell therapy for relapsed/refractory B cell lymphomas. [PDF]

Front Immunol
Pandey T, Samat D, Dahiya S, Patel SA.
europepmc   +1 more source

Development of a Novel Anti-CD19 Chimeric Antigen Receptor

Genetically modifying autologous T cells to express an anti-CD19 chimeric antigen receptor (CAR) has shown impressive response rates for the treatment of CD19+ B cell malignancies in several clinical trials (CTs). Making this treatment available to our patients prompted us to develop a novel CART19 based on our own anti-CD19 antibody (A3B1), followed ...
Castellà, Maria, Boronat, Anna||, Martín-Ibáñez, Raquel, Rodríguez, Vanina, Suñé, Guillermo||, Caballero, Miguel||, Marzal, Berta, Pérez-Amill, Lorena||, Martín-Antonio, B.||, Castaño Cardoso, Julio||, Bueno, Clara||, Balagué, Olga||, González-Navarro, Europa Azucena||, Serra-Pages, Carles, Engel, Pablo||, Vilella, Ramon, Benítez Ribas, Daniel||, Ortiz-Maldonado, Valentín||, Cid, Joan||, Tabera, Jaime||, Canals, Josep M.||, Lozano, Miquel||, Baumann, Tycho||, Vilarrodona, Anna||, Trias, Esteve||, Campo, Elias||, Menéndez Bujan, Pablo||, Urbano Ispizua, Álvaro||, Yagüe, Jordi||, Pérez-Galán, Patricia||, Rives, Susana||, Delgado, Julio||, Juan, Manel||   +32 more
openaire   +1 more source

Peptide‐directed nanovehicles enabling tumor‐selective ROS amplification and antitumor immunity

VIEW, EarlyView.
Cancer cells are vulnerable to oxidative stress, yet exploit immune tolerance to escape destruction. In contrast, their metabolic profile is markedly altered to support rapid proliferation, accompanied by elevated production of reactive oxygen species (ROS).
Manuela Calin, Galyna Bila, Ileana Manduteanu, Rostyslav Bilyy   +3 more
wiley   +1 more source

Reshaping the landscape of HLA desensitization through immune engineering. [PDF]

Transpl Int
Kervella D, Bestard O.
europepmc   +1 more source

CD21 and CD19: how B cells sense antigen [PDF]

Clinical and Experimental Immunology, 1994
openaire   +1 more source

Nanobodies as next‐generation targeting platforms: From discovery technologies to translational biomedicine

VIEW, EarlyView.
Nanobodies, derived from the variable domains of camelid heavy‐chain‐only antibodies, have emerged as transformative biomedical tools due to their nanoscale size, exceptional stability, and unique capacity to recognize cryptic epitopes. This review provides a comprehensive overview of the field, outlining the structural and biochemical features of ...
Zhenrui Ye, Xianyang Li, Meixiao Zhan
wiley   +1 more source