Results 211 to 220 of about 75,785 (301)

Anti-BCMA CAR-T cells attenuate microglial activation in progressive multiple sclerosis: indicating a plasma cell-microglia crosstalk. [PDF]

Signal Transduct Target Ther
Ismail FS, Hartung HP, Melzer N.
europepmc   +1 more source

Decreased renal function predicts severe cytokine release syndrome after CAR‐T‐cell therapy for large B‐cell lymphoma

British Journal of Haematology, EarlyView.
Summary Cytokine release syndrome (CRS) remains a major toxicity of chimeric antigen receptor (CAR) T‐cell therapy in large B‐cell lymphoma (LBCL), and robust pre‐infusion predictors are needed for risk‐adapted management. We retrospectively analysed LBCL patients in the Japanese nationwide registry who underwent CD19 CAR‐T‐cell therapy between 2019 ...
Yasuyuki Arai, Tomoyasu Jo, Takayuki Sato, Masatoshi Sakurai, Daisuke Kaji, Toshio Kitawaki, Kazuyuki Shimada, Tatsu Shimoyama, Satoshi Yoshihara, Shinichi Makita, Nobuharu Fujii, Go Yamamoto, Keisuke Kataoka, Emiko Sakaida, Hideki Goto, Yasuhiro Nakashima, Akiyo Yoshida, Yoshihiro Umezawa, Haryoon Kim, Motohiro Kato, Yoshiko Atsuta, Koji Kato   +21 more
wiley   +1 more source

Upregulation of CD1d and ULBP3 on B cells from healthy donors and chronic lymphocytic leukaemia patients does not prime them for killing by γδ T cells. [PDF]

PLoS One
David J, Walsh A, Seow KS, Walsh E, Elekes S, Upadhyay R, Taher NAB, Al Siyabi S, Melo AM, Waldron C, Vandenberghe E, McElligott AM, Doherty DG.   +12 more
europepmc   +1 more source

Clinical features and prognostic factors of adult systemic chronic active EBV disease: A retrospective analysis in Japan

British Journal of Haematology, EarlyView.
ALT and ferritin were adverse prognostic markers enabling risk stratification in adult systemic chronic active Epstein–Barr virus disease (sCAEBV). In hydroa vacciniforme lymphoproliferative disorder (HV‐LPD), Epstein–Barr virus (EBV) infection of CD4+ cells was associated with progression to sCAEBV.
Aika Fuseya, Masahide Yamamoto, Miwako Nishio, Ryo Kitabayashi, Akihiro Hirakawa, Hiroshi Yasui, Yoshihiro Umezawa, Keisuke Tanaka, Hayato Tamai, Yu Uemura, Kumi Oshima, Fumiaki Sano, Takehiko Mori, Ryuji Koike, Shouichi Ohga, Ayako Arai   +15 more
wiley   +1 more source

Evaluation of multi-antigen targeting ADCC strategies in pediatric BCP-ALL. [PDF]

J Immunother Cancer
Grain A, Ollier J, Le Calvez B, Guiet E, Thomas C, Couec ML, Camuset M, Rialland F, Eveillard M, Scotet E, Clémenceau B.   +10 more
europepmc   +1 more source

Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges

British Journal of Pharmacology, EarlyView.
This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu, Kaibin Dai, Zhensheng Lin, Mingfang Ye, Minfeng Chen, Xiaobo Li, Dongmei Zhang   +6 more
wiley   +1 more source

Bispecific Ligand‐Based EphB4 CAR‐T Cells Generated Using Ephrin‐B2 Show Potent Antitumor Activity Against Lung Adenocarcinoma

Cancer Science, EarlyView.
EphB4 and EphA2 positivity in lung adenocarcinoma samples was high. Ligand‐based EphB4 CAR‐T cells exhibit bispecificity, targeting both EphB4 and EphA2. EphB4 CAR‐T cells exert significant antitumor effects against lung adenocarcinoma. ABSTRACT Chimeric antigen receptor (CAR)‐T cells generated using ephrin‐B2, the natural ligand for ephrin type‐B ...
Hirotaka Kumeda, Koichi Hirabayashi, Shuji Mishima, Kotaro Morita, Yu Furui, Marina Fujioka, Tomoyuki Nakajima, Miyuki Tanaka, Yoshinori Sato, Takeshi Uehara, Shigeki Yagyu, Kimihiro Shimizu, Yozo Nakazawa   +12 more
wiley   +1 more source

Precision immunotherapy with CAR-T cells in pediatric B-cell acute lymphoblastic leukemia: advances and unanswered challenges. [PDF]

Front Oncol
Li F, Zheng L.
europepmc   +1 more source

Autologous CD19/CD22 Chimeric Antigen Receptor T-cells [PDF]

, 2020
openaire   +1 more source

Diverging in Vivo Immune Response Patterns After Oral Food Challenge in Peanut Allergic Adults

Clinical &Experimental Allergy, EarlyView.
After the oral food challenge, peanut (PN)‐allergic adults were monitored over 4 weeks, which revealed diverging immune response patterns, with strong responders (SR) exhibiting heightened Ara h 2+ B cell expansion, PN sIgE induction and increasing PN‐specific Tconv. Weak responders (WR) had more activated PN‐specific Tregs.
Florent Fauchère, Aikaterina Alexiou, Veronika Höfer, Kirsten Beyer, Sabine Dölle‐Bierke, Andreas Thiel, Margitta Worm, Julian Braun   +7 more
wiley   +1 more source