Results 221 to 230 of about 50,442 (246)

CD19 CAR antigen engagement mechanisms and affinity tuning

Science Immunology, 2023
Chimeric antigen receptor (CAR) T cell therapy relies on T cells that are guided by synthetic receptors to target and lyse cancer cells. CARs bind to cell surface antigens through an scFv (binder), the affinity of which is central to determining CAR T cell function and therapeutic success.
Changhao He, Jorge Mansilla-Soto, Nandish Khanra, Mohamad Hamieh, Victor Bustos, Alice J. Paquette, Andreina Garcia Angus, Derek M. Shore, William J. Rice, George Khelashvili, Michel Sadelain, Joel R. Meyerson   +11 more
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Retargeting CD19 Chimeric Antigen Receptor T Cells via Engineered CD19-Fusion Proteins

Molecular Pharmaceutics, 2019
CD19-targeted chimeric antigen receptor (CAR) T-cells (CAR19s) show remarkable efficacy in the treatment of relapsed/refractory acute lymphocytic leukemia and Non-Hodgkin's lymphoma. However, the use of CAR T-cell therapy against CD19-negative hematological cancers and solid tumors has been challenging.
Justin R. Klesmith, Lihe Su, Lan Wu, Ian A. Schrack, Fay J. Dufort, Alyssa Birt, Christine Ambrose, Benjamin J. Hackel, Roy R. Lobb, Paul D. Rennert   +9 more
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Donor-derived CD19 chimeric antigen receptor T cells

Current Opinion in Hematology, 2015
As immunotherapy matures into possible front-line therapy, new approaches are necessary to expand the capacity to treat more patients. Although most technologies for chimeric antigen receptor (CAR) therapies require autologous T cells, 'off the shelf' sources are highly desired.Sources of T cells for modification with CARs include cord blood and either
Nathan, Singh, David M, Barrett
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CD19 regulates B cell antigen receptor-mediated MHC class II antigen processing

Vaccine, 1999
In B cells, the processing of antigens in the context of MHC class II molecules is initiated by the binding of antigen to the B cell antigen receptor (BCR). The BCR serves two roles in antigen processing, signaling for enhanced processing and endocytosing bound antigen.
N M, Wagle, J H, Kim, S K, Pierce
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CD19 Antigen in Leukemia and Lymphoma Diagnosis and Immunotherapy

Leukemia & Lymphoma, 1995
The CD19 antigen plays an important role in clinical oncology. In normal cells, it is the most ubiquitously expressed protein in the B lymphocyte lineage. CD19 expression is induced at the point of B lineage commitment during the differentiation of the hematopoietic stem cell, and its expression continues through preB and mature B cell differentiation ...
R H, Scheuermann, E, Racila
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CD19 Fc-Fusion Protein for Detection of Cells Expressing Anti-CD19 Chimeric Antigen Receptors.

Blood, 2010
Abstract Abstract 3756 Chimeric Antigen Receptors (CARs) consist of the antigen-recognition portion of a monoclonal antibody fused to an intracellular signaling domain that is capable of activating T cells. CARs are displayed on the surface of transduced cells, performing non-MHC-restricted antigen recognition and ...
Satiro N. De Oliveira, Jiexin Wang, Roger P. Hollis, Donald B. Kohn   +3 more
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A single-cell atlas of CD19 chimeric antigen receptor T cells

Cancer Cell, 2023
Li et al. present a resource of single-cell RNA sequencing (scRNA-seq) data from the infusion products of relapsed or refractory large B cell lymphoma (rrLBCL) patients treated with standard-of-care axicabtagene ciloleucel and identify features that are significantly different between products from responders and non-responders at 3-month followup by ...
Xubin, Li, Jared, Henderson, Max J, Gordon, Irtiza, Sheikh, Loretta J, Nastoupil, Jason, Westin, Christopher, Flowers, Sairah, Ahmed, Linghua, Wang, Sattva S, Neelapu, Paolo, Strati, Qing, Deng, Michael R, Green   +12 more
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