Memory CD4 T cell subsets are kinetically heterogeneous and replenished from naive T cells at high levels [PDF]
Characterising the longevity of immunological memory requires establishing the rules underlying the renewal and death of peripheral T cells. However, we lack knowledge of the population structure and how self-renewal and de novo influx contribute to ...
Asquith+47 more
core +4 more sources
Defective FoxP3+ Treg cell differentiation in the gut of Type 1 Diabetic patients [PDF]
Environmental factors that act at the intestinal level such as diet, drugs, and microflora have a high impact on the pathogenesis of autoimmune Type 1 Diabetes (T1D), but it is still unclear how the gut milieu affects autoimmunity outside the intestine ...
Alberto Mariani+8 more
core +1 more source
IRX-2, a Novel Immunotherapeutic, Enhances Functions of Human Dendritic Cells [PDF]
Background: In a recent phase II clinical trial for HNSCC patients, IRX-2, a cell-derived biologic, promoted T-cell infiltration into the tumor and prolonged overall survival. Mechanisms responsible for these IRX-2-mediated effects are unknown.
A Lopez-Albaitero+47 more
core +4 more sources
Effect of synthetic and bovine milk conjugated linoleic acid (CLA) on immune function : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Nutrition Science at Massey University [PDF]
CLA is a collective name for a mixture of positional and geometrical isomers of linoleic acid (c-9, c-12-octadecadioenic acid) which possess conjugated double bonds.
Zhao, Hui
core
The cytolytic T lymphocyte response to the murine cytomegalovirus [PDF]
Limiting dilution (LD) analysis with two modifications, the expansion and the restimulation LD assay, led to the detection and quantification of two distinct in vivo maturation stages within the lineage of virus- specific self-restricted CTL after ...
Keil, Günther M.+2 more
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Capacity of different cell types to stimulate cytotoxic T lymphocyte precursor cells in the presence of interleukin 2 [PDF]
Plastic-adherent cells enriched for dendritic cells (AC) were found to be among the most potent stimulator cells for the activation of cytotoxic T lymphocytes (CTL) in vitro in the presence of interleukin 2 (IL 2) and a constant second set of allogeneic ...
Dröge, W.+6 more
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"Tolerization" of human T-helper cell clones by chronic exposure to alloantigen [PDF]
Induction of clonal anergy in T-helper (Th) cells may have a role in regulating immune responses. A model system for studying Th cell tolerization at the clonal level in vitro could be useful for investigating the mechanisms involved.
Brocker, Thomas+6 more
core
Interleukin 2 activation of natural killer cells rapidly induces the expression and phosphorylation of the Leu-23 activation antigen. [PDF]
IL-2 potentiates both growth and cytotoxic function of T lymphocytes and NK cells. Resting peripheral blood NK cells can respond directly to rIL-2, without requirement for accessory cells or cofactors, and enhanced cytotoxicity can be measured within a ...
Barney, C+6 more
core
Novel immunotherapies for immune-mediated haemolytic anaemia in dogs and people [PDF]
Aerts+111 more
core +1 more source
Lymphocyte subsets as surrogate markers in antiretroviral therapy. [PDF]
Bogner, Johannes R.+1 more
core +1 more source