Results 31 to 40 of about 3,143,934 (294)

A systematic approach for the identification of novel, serologically reactive recombinant Varicella-Zoster Virus (VZV) antigens

Virology Journal, 2010
Background Varicella-Zoster virus causes chickenpox upon primary infection and shingles after reactivation. Currently available serological tests to detect VZV-specific antibodies are exclusively based on antigens derived from VZV-infected cells. Results
Lueking Angelika, Sander Michaela, Noelting Christina, Janke Tobias, Pfrepper Klaus-Ingmar, Vizoso Pinto Maria G, Haas Juergen, Nitschko Hans, Jaeger Gundula, Baiker Armin   +9 more
doaj   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

H Antigen expression modulates epidermal Keratinocyte Integrity and differentiation

Biological Research
Background ABO blood group antigens (ABH antigens) are carbohydrate chains glycosylated on epithelial and red blood cells. Recent findings suggest reduced ABH expression in psoriasis and atopic dermatitis, a chronic inflammatory skin disease with ...
Seon-Pil Jin, Jang-Hee Oh, Namjoo Kaylee Kim, Jin Ho Chung   +3 more
doaj   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

SOLUBLE DIFFERENTIATING ANTIGENS AND HISTOCOMPATIBILITY MOLECULES IN PATIENTS WITH DIFFERENT KIND OF TRAUMA

Сеченовский вестник, 2010
In biological fluids of trauma patients the essential changes in soluble forms of immune system cells membrane antigens in different states have been revealed.
A. V. Karaulov, M. Yu. Lebedev, V. V. Novikov   +2 more
doaj  

Autoreactive, Low-Affinity T Cells Preferentially Drive Differentiation of Short-Lived Memory B Cells at the Expense of Germinal Center Maintenance

Cell Reports, 2018
Summary: B cell fate decisions within a germinal center (GC) are critical to determining the outcome of the immune response to a given antigen.
Rajiv W. Jain, Kate A. Parham, Yodit Tesfagiorgis, Heather C. Craig, Emiliano Romanchik, Steven M. Kerfoot   +5 more
doaj   +1 more source

Expression dynamics of integrin α2, α3, and αV upon osteogenic differentiation of human mesenchymal stem cells

Stem Cell Research & Therapy, 2020
Background The differentiation of human mesenchymal stem cells (hMSCs) into osteoblasts (OBs) is a prerequisite for bone formation. However, little is known about the definitive surface markers for OBs during osteogenesis.
Hyun Min Lee, Se-Ri Seo, Jeeseung Kim, Min Kyu Kim, Hyosun Seo, Kyoung Soo Kim, Young-Joo Jang, Chun Jeih Ryu   +7 more
doaj   +1 more source

Osteoclast differentiation antigen.

Histology and histopathology, 1996
Osteoclasts are the primary cells which perform bone resorption. The origin of these multinucleated giant cells is the haematopoietic stem cells. The differentiation pathway of the osteoclasts has so far been well studied and the cell-lineage of these bone resorbing cells is considered to be close but not identical to the monocytes/macrophages.
Kukita, T., Kukita, A.
openaire   +2 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source