Results 51 to 60 of about 367,534 (310)

SOLUBLE DIFFERENTIATING ANTIGENS AND HISTOCOMPATIBILITY MOLECULES IN PATIENTS WITH DIFFERENT KIND OF TRAUMA

open access: yesСеченовский вестник, 2010
In biological fluids of trauma patients the essential changes in soluble forms of immune system cells membrane antigens in different states have been revealed.
A. V. Karaulov   +2 more
doaj  

Carcinoembryonic Antigen Gene Family [PDF]

open access: yes, 1991
The carcinoembryonic antigen (CEA) gene family belongs to the immunoglobulin supergene family and can be divided into two main subgroups based on sequence comparisons.
Accili   +236 more
core   +1 more source

Osteoclast differentiation antigen.

open access: yesHistology and histopathology, 1996
Osteoclasts are the primary cells which perform bone resorption. The origin of these multinucleated giant cells is the haematopoietic stem cells. The differentiation pathway of the osteoclasts has so far been well studied and the cell-lineage of these bone resorbing cells is considered to be close but not identical to the monocytes/macrophages.
Kukita, T., Kukita, A.
openaire   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Autoreactive, Low-Affinity T Cells Preferentially Drive Differentiation of Short-Lived Memory B Cells at the Expense of Germinal Center Maintenance

open access: yesCell Reports, 2018
Summary: B cell fate decisions within a germinal center (GC) are critical to determining the outcome of the immune response to a given antigen.
Rajiv W. Jain   +5 more
doaj   +1 more source

Expression dynamics of integrin α2, α3, and αV upon osteogenic differentiation of human mesenchymal stem cells

open access: yesStem Cell Research & Therapy, 2020
Background The differentiation of human mesenchymal stem cells (hMSCs) into osteoblasts (OBs) is a prerequisite for bone formation. However, little is known about the definitive surface markers for OBs during osteogenesis.
Hyun Min Lee   +7 more
doaj   +1 more source

CD1-mediated immune responses in mucosal tissues: molecular mechanisms underlying lipid antigen presentation system

open access: yesExperimental and Molecular Medicine, 2023
The cluster of differentiation 1 (CD1) molecule differs from major histocompatibility complex class I and II because it presents glycolipid/lipid antigens. Moreover, the CD1-restricted T cells that recognize these self and foreign antigens participate in
Seohyun Kim, Sumin Cho, Ji Hyung Kim
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

open access: yesMolecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken   +7 more
wiley   +1 more source

Future therapeutic targets in rheumatoid arthritis? [PDF]

open access: yes, 2017
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by persistent joint inflammation. Without adequate treatment, patients with RA will develop joint deformity and progressive functional impairment.
A Balanescu   +154 more
core   +1 more source

Home - About - Disclaimer - Privacy