Results 1 to 10 of about 4,152 (113)

The small tumor antigen of Merkel cell polyomavirus accomplishes cellular transformation by uniquely localizing to the nucleus despite the absence of a known nuclear localization signal [PDF]

Virology Journal
Background Merkel Cell Carcinoma (MCC) is an aggressive skin cancer that is three times deadlier than melanoma. In 2008, it was found that 80% of MCC cases are caused by the genomic integration of a novel polyomavirus, Merkel Cell Polyomavirus (MCPyV ...
Kaira R. Thevenin, Isabella S. Tieche, Cody E. Di Benedetto, Matt Schrager, Kristine N. Dye   +4 more
doaj   +2 more sources

Identification of a novel human polyomavirus in organs of the gastrointestinal tract [PDF]

, 2013
Peer reviewedPublisher ...
Calvignac-Spencer, Sebastien, Ehlers, Bernhard, Hofmann, Jorg, Korup, Sarah, Moens, Ugo, Rietscher, Janita, Sauer, Igor, Schmuck, Rosa, Trusch, Franziska, Voigt, Sebastian   +9 more
core   +8 more sources

Direct cellular reprogramming enables development of viral T antigen–driven Merkel cell carcinoma in mice

The Journal of Clinical Investigation, 2022
Merkel cell carcinoma (MCC) is an aggressive neuroendocrine skin cancer that frequently carries an integrated Merkel cell polyomavirus (MCPyV) genome and expresses viral transforming antigens (TAgs).
Monique E. Verhaegen, Paul W. Harms, Julia J. Van Goor, Jacob Arche, Matthew T. Patrick, Dawn Wilbert, Haley Zabawa, Marina Grachtchouk, Chia-Jen Liu, Kevin Hu, Michael C. Kelly, Ping Chen, Thomas L. Saunders, Stephan Weidinger, Li-Jyun Syu, John S. Runge, Johann E. Gudjonsson, Sunny Y. Wong, Isaac Brownell, Marcin Cieslik, Aaron M. Udager, Arul M. Chinnaiyan, Lam C. Tsoi, Andrzej A. Dlugosz   +23 more
doaj   +1 more source

Neoplastic transformation of porcine mammary epithelial cells in vitro and tumor formation in vivo. [PDF]

, 2015
BackgroundThe mammary glands of pigs share many functional and morphological similarities with the breasts of humans, raising the potential of their utility for research into the mechanisms underlying normal mammary function and breast carcinogenesis ...
Borowsky, AD, Cardiff, RD, Hovey, RC, Manjarin, R, Rowson-Hodel, AR, Trott, JF   +5 more
core   +4 more sources

Review on the role of the human Polyomavirus JC in the development of tumors [PDF]

, 2017
Almost one fifth of human cancers worldwide are associated with infectious agents, either bacteria or viruses, and this makes the possible association between infections and tumors a relevant research issue.
Manola Comar, Pasquale Ferrante, Serena Delbue   +2 more
core   +1 more source

Receptor-Binding and Oncogenic Properties of Polyoma Viruses Isolated from Feral Mice [PDF]

, 2011
Laboratory strains of the mouse polyoma virus differ markedly in their abilities to replicate and induce tumors in newborn mice. Major determinants of pathogenicity lie in the sialic binding pocket of the major capsid protein Vp1 and dictate receptor ...
Benjamin, Thomas L., Bronson, Roderick Terry, Carroll, John, Dahl, Jean Stokes, Dey, Dilip, Kreisman, Lori, Telford, Samuel, Velupillai, Palanivel   +7 more
core   +1 more source

Viral MicroRNA Effects on Pathogenesis of Polyomavirus SV40 Infections in Syrian Golden Hamsters [PDF]

, 2014
Shaojie Zhang, Vojtech Sroller, Preeti Zanwar, Steven J. Halvorson, Nadim J. Ajami, Corey W. Hecksel, Jody L. Swain, Connie Wong, Janet S. Butel, Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, United States
Ajami, Nadim J., Butel, Janet S., Chen, Chun Jung, Halvorson, Steven J., Hecksel, Corey W., Sroller, Vojtech, Sullivan, Christopher S., Swain, Jody L., Wong, Connie, Zanwar, Preeti, Zhang, Shaojie   +10 more
core   +3 more sources

Does a New Polyomavirus Contribute to Merkel Cell Carcinoma? [PDF]

, 2011
A new technique designed to hunt for non-human transcripts has identified a novel SV40-like virus present in the majority of Merkel cell carcinomas.
DeCaprio, James A., Garneski, Kelly M, Nghiem, Paul   +2 more
core   +1 more source

Merkel cell polyomavirus: molecular insights into the most recently discovered human tumour virus. [PDF]

, 2014
A fifth of worldwide cancer cases have an infectious origin, with viral infection being the foremost. One such cancer is Merkel cell carcinoma (MCC), a rare but aggressive skin malignancy.
Abdul-Sada, H, Adzahar, NS, Knight, LM, Macdonald, A, Nwogu, N, Stakaitytė, G, Whitehouse, A, Wood, JJ   +7 more
core   +3 more sources

Inhibition of Simian Virus 40 replication by targeting the molecular chaperone function and ATPase activity of T antigen [PDF]

, 2009
Polyomaviruses such as BK virus and JC virus have been linked to several diseases, but treatments that thwart their propagation are limited in part because of slow growth and cumbersome culturing conditions.
Brodsky, JL, Fanning, E, Fewell, SW, Ishwad, C, Lingwood, CA, Pipas, JM, Seguin, SP, Vats, A, Wipf, P, Wright, CM, Zhang, H   +10 more
core   +1 more source