Results 41 to 50 of about 4,221 (179)

Detection of phosphotyrosine-containing proteins in polyomavirus middle tumor antigen-transformed cells after treatment with a phosphotyrosine phosphatase inhibitor. [PDF]

Molecular and Cellular Biology, 1987
Cells transformed with the middle tumor antigen (mT) of polyomavirus were treated with sodium orthovanadate (Na3VO4), an inhibitor of phosphotyrosine phosphatases, to enhance for the detection of cellular proteins which are phosphorylated on tyrosine.
W, Yonemoto, A J, Filson, A E, Queral-Lustig, J Y, Wang, J S, Brugge   +4 more
openaire   +2 more sources

Merkel Cell Carcinoma With Divergent Differentiation—Or Something Else? A Triphasic Cutaneous Carcinoma With Lineage Plasticity

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Merkel cell carcinoma (MCC) is a rare, aggressive cutaneous neuroendocrine carcinoma that typically arises in sun‐exposed skin of older or immunosuppressed patients. Combined or collision tumors involving MCC and other cutaneous malignancies are uncommon, and tumors exhibiting more than two distinct malignant phenotypes are exceptionally rare.
Zeinab Khalil, Hozaifa Elameen, Ahmed K. Alomari   +2 more
wiley   +1 more source

A role for the small GTPase Rac in polyomavirus middle-T antigen-mediated activation of the serum response element and in cell transformation [PDF]

Oncogene, 1997
The oncogenic proteins encoded by papovaviruses, the tumor antigens, have been extensively used as model systems to study mitogenic signaling and cell transformation. These proteins stimulate cell growth in cultured cells and induce tumors in virus infected or transgenic animals.
Urich M, Senften M, Shaw PE, Ballmer-Hofer K   +3 more
openaire   +3 more sources

Identification of African Elephant Polyomavirus in wild elephants and the creation of a vector expressing its viral tumor antigens to transform elephant primary cells

PLOS ONE, 2021
Wild elephant populations are declining rapidly due to rampant killing for ivory and body parts, range fragmentation, and human-elephant conflict. Wild and captive elephants are further impacted by viruses, including highly pathogenic elephant endotheliotropic herpesviruses.
Virginia R. Pearson, Jens B. Bosse, Orkide O. Koyuncu, Julian Scherer, Cristhian Toruno, Rosann Robinson, Lisa M. Abegglen, Joshua D. Schiffman, Lynn W. Enquist, Glenn F. Rall   +9 more
openaire   +5 more sources

BK virus large T and VP-1 expression in infected human renal allografts [PDF]

, 2017
Objective. We investigated the expression of early and late phase BK virus (BKV) proteins and their interactions with host cell proteins in renal allografts, with ongoing polyomavirus associated nephropathy (PVAN), and correlated this with the nuclear ...
Dürmüller, Ursula, Gudat, Fred, Hirsch, Hans H., Mihatsch, Michael J., Schaub, Stefan, Seemayer, Christian A., Seemayer, Norbert H.   +6 more
core  

Dissecting the roles of viral T-antigens in Merkel cell carcinoma [PDF]

, 2022
Merkel cell carcinoma (MCC) is a rare but aggressive form of skin malignancy with increasing incidence. Merkel cell polyomavirus (MCPyV) is associated with ~80% of MCCs, and a minority is caused by ultra-violet (UV)-induced DNA damage.
Gao, Jiwei
core   +1 more source

Production of recombinant VP1-derived virus-like particles from novel human polyomaviruses in yeast [PDF]

, 2015
Background: Eleven new human polyomaviruses (HPyVs) have been identified in the last decade. Serological studies show that these novel HPyVs sub-clinically infect humans at an early age.
Alma Gedvilaite, Danguole Ziogiene, Egle Mazeike, Jomante Stonyte, Kestutis Sasnauskas, Milda Norkiene   +5 more
core   +1 more source

Deletion of Proline-Rich Domain in Polyomavirus T Antigens Results in Virus Partially Defective in Transformation and Tumorigenesis

Virology, 1998
Polyomavirus productively infects mouse cells, transforms rat fibroblasts in culture, and induces a broad spectrum of tumors when inoculated into newborn mice. The expression of large, middle, and small T antigen are necessary for virus growth and oncogenic transformation. We have generated a small deletion in a region common to both large and middle T
Yi, Xiande, Freund, Robert
openaire   +2 more sources

A completely transformation-defective point mutant of polyomavirus middle T antigen which retains full associated phosphatidylinositol kinase activity [PDF]

Journal of Virology, 1990
By using a random mutagenesis procedure combined with a recombinant retrovirus vector, mutants of polyomavirus middle T antigen (MTAg) were generated. Three new MTAg mutants with various degrees of transformation competence were more thoroughly characterized. All of the mutants produced a stable MTAg, as assessed by metabolic labeling or immunoblotting,
B J, Druker, L E, Ling, B, Cohen, T M, Roberts, B S, Schaffhausen   +4 more
openaire   +2 more sources

The interplay between viral-derived miRNAs and host immunity during infection [PDF]

, 2019
MicroRNAs are short non-coding RNAs that play a crucial role in the regulation of gene expression during cellular processes. The host-encoded miRNAs are known to modulate the antiviral defense during viral infection.
Ingle, Harshad, Kumar, Ashish, Kumar, Himanshu, Mishra, Richa   +3 more
core   +1 more source