Results 51 to 60 of about 4,221 (179)
Modulation of Autophagy-Like Processes by Tumor Viruses [PDF]
, 2014 Autophagy is an intracellular degradation pathway for long-lived proteins and organelles. This process is activated above basal levels upon cell intrinsic or environmental stress and dysregulation of autophagy has been linked to various human diseases ...
Mack, Hildegard I. D., Munger, Karl
core +1 more source
Nonclassical MHC‐I Molecules: Emerging Therapeutic Targets in Next‐Generation Immunotherapy
MedComm, Volume 7, Issue 5, May 2026.Immunotherapies dependent on classical MHC‐I molecules face significant challenges, including extreme polymorphism and frequent downregulation in pathological conditions. This review discusses how nonclassical MHC‐I molecules (HLA‐E, HLA‐F, HLA‐G, CD1, MR1) may potentially circumvent these limitations through restricted genetic diversity, stable ...
Wanlin He, Andrew J. McMichael
wiley +1 more source
PLOS Pathogens, 2016 Merkel cell polyomavirus (MCPyV) is an etiological agent of Merkel cell carcinoma (MCC), a highly aggressive skin cancer. The MCPyV small tumor antigen (ST) is required for maintenance of MCC and can transform normal cells. To gain insight into cellular perturbations induced by MCPyV ST, we performed transcriptome analysis of normal human fibroblasts ...
Christian Berrios +9 more
openaire +6 more sources
An acidic region of the 89K murine cytomegalovirus immediate early protein interacts with DNA [PDF]
, 1992 The product of the ie 1 gene, the regulatory immediate early protein pp89 of murine cytomegalovirus (MCMV), interacts with core histones, which can mediate the association of pp89 with DNA.
Koszinowski, Ulrich H. +3 more
core +1 more source
An Accurate Genetic Colocalisation Method for the HLA Locus
HLA, Volume 107, Issue 5, May 2026.ABSTRACT Genetic colocalisation analyses are frequently conducted to determine if causal signals at a genetic locus are shared between two phenotypes. However, colocalisation is rarely undertaken at the HLA locus, due to its complex linkage disequilibrium (LD) and high polymorphism density.
Guillaume Butler‐Laporte +18 more
wiley +1 more source
"Alternative" endocytic mechanisms exploited by pathogens: new avenues for therapeutic delivery? [PDF]
, 2007 Some pathogens utilize unique routes to enter cells that may evade the intracellular barriers encountered by the typical clathrin-mediated endocytic pathway.
Medina-Kauwe, LK
core +1 more source
RB1 inactivation in cutaneous carcinomas
Histopathology, Volume 88, Issue 4, Page 769-789, March 2026.Among skin carcinomas, recurrent RB1 inactivation is observed in Merkel cell carcinoma, in a subset of squamous cell carcinoma with bowenoid morphology, in sebaceous carcinoma and in the recently described Wnt/beta‐catenin rosette‐forming carcinoma.
Tiffany Liv +8 more
wiley +1 more source
Speculations on the clinical significance of asymptomatic viral infections [PDF]
, 2016 A detailed understanding of asymptomatic chronic viral infections is critical to analyse their pathogenesis, assess the severity and burden of disease and, where required, optimize public health control measures.
Gentile, Giuseppe, Micozzi, Alessandra
core +1 more source
Molecular Oncology, Volume 20, Issue 2, Page 331-347, February 2026.This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian +10 more
wiley +1 more source
Tumor Immunotherapy and Microbiome: From Bench‐to‐Bedside Applications
MedComm, Volume 7, Issue 2, February 2026.The microbiome is related to the efficacy of immunotherapy and can be utilized to predict the efficacy and adverse reactions of immunotherapy. Microbiome‐targeted intervention strategies can improve the efficacy of ICI, but necessitating more comprehensive exploration.
Anqi Lin +12 more
wiley +1 more source