Results 31 to 40 of about 4,221 (179)

Intrachromosomal recombination mediated by the polyomavirus large T antigen [PDF]

, 1995
We used a spleen necrosis virus-based retroviral vector to introduce the polyomavirus replication origin into rat cells and developed a system to analyze homologous recombination events that do not reconstitute a selectable marker.
Alt, Asselin, Bastin, Bird, Botchan, Bouchard, Bouchard, Bouchard, Cegielska, Colantuoni, Dornreiter, Dougherty, Hirt, Israel, Land, Larose, Liskay, Miller, Pall, Pellegrini, Roberge, Scheidtmann, Scheidtmann, Schimke, Shah, Southern, Spradling, St-Onge, St-Onge, St-Once, St-Onge, Thomas, Tlsty, Varshavski, Wang, Watanabe   +35 more
core   +1 more source

Glucocorticoids facilitate the stable transformation of embryonal rat fibroblasts by a polyomavirus large tumor antigen-deficient mutant. [PDF]

Proceedings of the National Academy of Sciences, 1988
The addition of glucocorticoids to the growth medium could substitute for the expression of the polyomavirus large tumor antigen in the transformation of rat fibroblasts in vitro. After transfection with a large tumor antigen-deficient mutant of polyomavirus, pbc1051, high-frequency permanent transformation was observed, if the cells were grown in ...
I, Martens, M, Nilsson, G, Magnusson, S, Linder   +3 more
openaire   +2 more sources

Expression of infectious murine leukemia viruses by RAW264.7 cells, a potential complication for studies with a widely used mouse macrophage cell line [PDF]

, 2008
The mouse macrophage-like cell line RAW264.7, the most commonly used mouse macrophage cell line in medical research, was originally reported to be free of replication-competent murine leukemia virus (MuLV) despite its origin in a tumor induced by Abelson
Janet W Hartley, Leonard H Evans, Kim Y Green, Zohreh Naghashfar, Alfonso R Macias, Patricia M Zerfas, Jerrold M Ward   +6 more
core   +2 more sources

Mitosis-specific phosphorylation of polyomavirus middle-sized tumor antigen and its role during cell transformation. [PDF]

Proceedings of the National Academy of Sciences, 1993
Transformation of cells in culture by polyomavirus is mediated by one of its early gene products, middle-sized tumor antigen (MTAg). This protein forms multiple complexes with cellular enzymes such as tyrosine kinases (pp60c-src), a phosphatidylinositol 3-kinase, and phosphatase 2A.
Pérez L, Paasinen A, Schnierle B, Käch S, Senften M, Ballmer-Hofer K   +5 more
openaire   +3 more sources

Surface charge of Merkel cell polyomavirus small T antigen determines cell transformation through allosteric FBW7 WD40 domain targeting [PDF]

Oncogenesis, 2020
AbstractMerkel cell polyomavirus (MCV) small T (sT) is the main oncoprotein in Merkel cell carcinoma (MCC) development. A unique domain of sT, LT stabilization domain (LSD), has been reported to bind and inactivate multiple SCF (Skp1-Cullin-F-box) E3 ligases.
Nnenna Nwogu, Luz E. Ortiz, Hyun Jin Kwun   +2 more
openaire   +2 more sources

Structural elements that regulate pp59c-fyn catalytic activity, transforming potential, and ability to associate with polyomavirus middle-T antigen [PDF]

Journal of Virology, 1991
Except for its unique amino-terminal region (residues 1 through 83), which possibly dictates substrate recognition, pp59c-fyn bears a high degree of homology with other members of the src family of tyrosine kinases. Here we show that the carboxy terminus of pp59c-fyn is necessary for stable middle-T-antigen association, that pp59c-fyn is normally ...
S H, Cheng, P C, Espino, J, Marshall, R, Harvey, J, Merrill, A E, Smith   +5 more
openaire   +2 more sources

Chronic Viral Infection and Primary Central Nervous System Malignancy [PDF]

, 2010
Primary central nervous system (CNS) tumors cause significant morbidity and mortality in both adults and children. While some of the genetic and molecular mechanisms of neuro-oncogenesis are known, much less is known about possible epigenetic ...
Robert Saddawi-Konefka, John R. Crawford, JR Abend, N Ahsan, RR Arthur, J Baillie, G Barbanti-Brodano, G Barbanti-Brodano, G Barbanti-Brodano, M Benko, DJ Bergsagel, G Bogdanovic, R Boldorini, R Boldorini, ML Bondy, KA Boyle, JS Butel, R Caldarelli-Stefano, M Carbone, MT Caserta, PK Chan, J Cinatl Jr, J Cinatl Jr, J Cinatl Jr, J Cinatl Jr, J Cinatl, DA Clark, CS Cobbs, CS Cobbs, CS Cobbs, A Corallini, JR Crawford, JR Crawford, S Croul, L Cuomo, T Dalianis, AJ Davison, L Bolle De, M Mattei De, FB Dean, L Valle Del, L Valle Del, L Valle Del, L Valle Del, L Valle Del, A Dolan, CG Duncan, K Dorries, DW Ellison, EA Engels, D Fioriti, L Flamand, RL Garcea, RL Garcea, SD Gardner, AF Gazdar, VS Goldmacher, ML Gulley, CB Hall, CB Hall, CB Hall, MS Hamza, KF Harris, H Hayashi, SD Hayward, U Hohlweg, A Hossain, H Huang, AJ Hume, B Jasani, FM Jault, RT Javier, M Jiang, RA Johnson, RA Johnson, RA Johnson, F Kashanchi, JY Kim, DW Kimberlin, G Klein, WA Knowles, K Kosulin, T Kouhata, P Krieg, B Krynska, SK Lau, JA Lednicky, W Lee, JB Liao, WT London, WT London, M Luppi, MS Maginnis, T Maisch, EO Major, F Martini, AL McCormick, DJ McGeoch, W Meinke, M Michaelis, M Michaelis, G Miller, NR Miller, DA Mitchell, LB Nabors, M Negrini, AM Neves, V Nunbhakdi-Craig, H Okamoto, T Okuno, MB Oldstone, BL Padgett, DM Parkin, G Perez-Liz, S Pina-Oviedo, JM Pipas, S Poltermann, RM Prins, J Rajcani, FA Ray, A Rencic, HA Rogers, DE Rollison, DE Rollison, JJ Rushton, J Sabatier, ME Scheurer, M Scholz, T Shenk, T Shenk, T Shibutani, DT Simmons, A Skaletskaya, YJ Song, L Soroceanu, N Stewart, K Straat, K Tabuchi, K Tabuchi, M Tognon, C Trabanelli, RK Vasishta, A Volpi, DL Walker, X Wang, S Weggen, E White, MK White, M Wrensch, M Wrensch, M Wrensch, M Wrensch, Y Yabe, K Yamanishi, Y Yogo, T Yoshikawa, Y Yu, DM Zerr, H Hausen zur   +158 more
core   +2 more sources

Binding of p53 and p105-RB is not sufficient for oncogenic transformation by a hybrid polyomavirus-simian virus 40 large T antigen [PDF]

Journal of Virology, 1990
To identify regions on the large T antigens of simian virus 40 (SV40) and polyomavirus which are involved in oncogenic transformation, we constructed plasmids encoding hybrid polyomavirus-SV40 large T antigens. The hybrid T antigens were expressed in G418 sulfate-resistant pools of rat F2408 cells, and extracts of such pools were immunoprecipitated ...
J J, Manfredi, C, Prives
openaire   +2 more sources

Cancer vaccines: uses of HLA transgenic mice compared to genetically modified mice [PDF]

, 2008
Many tumor antigens have been identified that can be targeted by the immune system. Animal models that have been genetically modified to express human HLA molecules instead of their own MHC antigens have shown to be valuable in the discovery of peptides ...
McArdle, SE
core  

From Data to Decisions: How Machine Learning and Generative Artificial Intelligence Are Redefining Precision Medicine in Kidney Transplantation

Organ Medicine, Volume 3, Issue 2, Page 102-118, June 2026.
This review evaluates how machine learning, multimodal integration, and generative AI optimize kidney transplant outcomes. These tools enable superior prediction and personalized therapy but face hurdles in data volume, generalizability, and ethics. Future clinical adoption depends on continued innovation and multidisciplinary collaboration to overcome
Maoxin Liao, Cheng Yang
wiley   +1 more source