Antiviral regulator TRIM25 as a prognostic marker of better survival in Merkel cell carcinoma: Association with MCPyV status. [PDF]
Int J CancerWhat's new? TRIM25 is known for its role in antiviral immunity and association with poor prognosis in various cancers. This study reveals an association between high TRIM25 expression and Merkel cell polyomavirus positivity in Merkel cell carcinoma.
Fagerstedt KW +6 more
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The amino terminus of polyomavirus middle T antigen is required for transformation [PDF]
Journal of Virology, 1990 In polyomavirus-transformed cells, pp60c-src is activated by association with polyomavirus middle T antigen. These complexes have a higher tyrosine kinase activity compared with that of unassociated pp60c-src. Genetic analyses have revealed that the carboxy-terminal 15 amino acids of pp60c-src and the amino-terminal half of middle T antigen are ...
D N, Cook, J A, Hassell
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Properties of cells transformed by the middle T-antigen-coding region of polyomavirus [PDF]
Journal of Virology, 1986 A series of 10 Fischer rat transformed clonal cell lines were independently obtained in infections with a defective polyomavirus containing a scrambled genome except for an intact middle and small T-antigen-coding region. These cells synthesize middle and small T antigens; no fragment of large T antigen can be detected in any of them.
C, Priehs +3 more
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The major site of tyrosine phosphorylation in polyomavirus middle T antigen is not required for transformation [PDF]
Journal of Virology, 1984 The induction of tumors and cellular transformation mediated by polyomavirus requires the action of middle T antigen. Accordingly, we have begun to define the domains of the viral protein important for these processes to learn more about its site and mechanism of action.
A M, Mes-Masson +2 more
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Association of p60fyn with middle tumor antigen in murine polyomavirus-transformed rat cells [PDF]
Journal of Virology, 1989 Rabbit antisera raised against human FYN-specific peptides were used to evaluate the expression of the fyn gene product in normal and murine polyomavirus middle tumor antigen (MTAg)-transformed rat cells. The antisera were capable of detecting p60fyn in both normal and MTAg-transformed cells.
I D, Horak +4 more
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Mutational analysis of polyomavirus small-T-antigen functions in productive infection and in transformation [PDF]
Journal of Virology, 1989 The function of polyomavirus small T antigen in productive infection and in transformation was studied. Transfection of permissive mouse cells with mixtures of mutants that express only one type of T antigen showed that small T antigen increased large-T-antigen-dependent viral DNA synthesis approximately 10-fold.
I, Martens +3 more
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Significance of the gastrin homology and surrounding sequences in polyomavirus middle T antigen for cell transformation [PDF]
Journal of Virology, 1986 Deletion of residues 305 to 327 of polyomavirus middle T antigen, including the (Glu)6-Tyr-315 sequence that is a preferred site of phosphorylation in vitro by pp60c-src, markedly altered viral transformation of rat cells. The efficiency of transformation by the deletion mutant depended on how it was introduced into cells, and the resulting ...
K L, Clark, W R, Folk
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Analysis of middle tumor antigen and pp60c-src interactions in polyomavirus-transformed rat cells [PDF]
Journal of Virology, 1987 The relative abundance of pp60c-src molecules associated with polyomavirus (Py) middle tumor antigen (MTAg) and the relative abundance of MTAg associated with pp60c-src in a variety of Py-transformed rat cells was determined by quantitative immunoblot analyses which detect pp60c-src or Py MTAg. The results demonstrate that approximately 5 to 10% of the
J B, Bolen +3 more
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A Transformation-Defective Polyomavirus Middle T Antigen with a Novel Defect in PI3 Kinase Signaling [PDF]
Journal of Virology, 2017 ABSTRACT Middle T antigen (MT), the principal oncoprotein of murine polyomavirus, transforms by association with cellular proteins. Protein phosphatase 2A (PP2A), YAP, Src family tyrosine kinases, Shc, phosphatidylinositol 3-kinase (PI3K), and phospholipase C-γ1 (PLCγ1) have all been implicated in MT transformation. Mutant dl1015,
Deborah, Denis +2 more
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Association of p62c-yes with polyomavirus middle T-antigen mutants correlates with transforming ability [PDF]
Journal of Virology, 1990 A number of mutants of polyomavirus middle T antigen (MTag) were constructed into replication-competent avian retroviruses. To assess the ability of these MTag variants to transform and to associate with the avian p60c-src and p62c-yes proto-oncogene products, we used these viruses to infect chicken embryo fibroblasts.
S, Kornbluth +4 more
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