Results 51 to 60 of about 243,841 (269)

Identification of B cell antigens in solid cancer: initial insights and functional implications

Frontiers in Immunology
Cancer antigen discovery has mostly focused on T cell antigens, while antigens driving B cell responses have been largely overlooked despite representing another important branch of adaptive immune responses in cancer.
Jung-In Yang, Philip Moresco, Philip Moresco, Philip Moresco, Douglas Fearon, Douglas Fearon, Min Yao, Min Yao   +7 more
doaj   +1 more source

Differential T cell response against BK virus regulatory and structural antigens: A viral dynamics modelling approach.

PLoS Computational Biology, 2018
BK virus (BKV) associated nephropathy affects 1-10% of kidney transplant recipients, leading to graft failure in about 50% of cases. Immune responses against different BKV antigens have been shown to have a prognostic value for disease development.
Arturo Blazquez-Navarro, Thomas Schachtner, Ulrik Stervbo, Anett Sefrin, Maik Stein, Timm H Westhoff, Petra Reinke, Edda Klipp, Nina Babel, Avidan U Neumann, Michal Or-Guil   +10 more
doaj   +1 more source

Viral sequestration of antigen subverts cross presentation to CD8(+) T cells. [PDF]

PLoS Pathogens, 2009
Virus-specific CD8(+) T cells (T(CD8+)) are initially triggered by peptide-MHC Class I complexes on the surface of professional antigen presenting cells (pAPC). Peptide-MHC complexes are produced by two spatially distinct pathways during virus infection.
Eric F Tewalt, Jean M Grant, Erica L Granger, Douglas C Palmer, Neal D Heuss, Dale S Gregerson, Nicholas P Restifo, Christopher C Norbury   +7 more
doaj   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

DEVELOPMENT OF PRODUCTION TECHNOLOGY AND QUALITY ASSURANCE OF THE POLYVALENT SERUM AGAINST VIRAL PNEUMO-ENTERITIS OF CALVES

Ветеринарная патология, 2013
Viral pneumo-enteritis of calves (CPE) is widely distributed in Russia and other foreign countries. The viruses like PIV-3, IBR, BVD, calicivirus, reovirus and adenovirus are considered the main pathogens for CPE, which accounts for 33,2 to 60% in large ...
Evgeniy Vladimirovich Susskiy, N. Y. Basova   +1 more
doaj  

A Consistent Orally-Infected Hamster Model for Enterovirus A71 Encephalomyelitis Demonstrates Squamous Lesions in the Paws, Skin and Oral Cavity Reminiscent of Hand-Foot-and-Mouth Disease. [PDF]

PLoS ONE, 2016
Enterovirus A71 (EV-A71) causes self-limiting, hand-foot-and-mouth disease (HFMD) that may rarely be complicated by encephalomyelitis. Person-to-person transmission is usually by fecal-oral or oral-oral routes.
Win Kyaw Phyu, Kien Chai Ong, Kum Thong Wong   +2 more
doaj   +1 more source

Diagnosis and management of chronic viral hepatitis: Antigens, antibodies and viral genomes [PDF]

Best Practice & Research Clinical Gastroenterology, 2008
Virological tools, including serological and molecular tools, are needed to diagnose chronic hepatitis B and C infections. They may also be useful to establish their prognosis, but they have found their principal application in guiding treatment decisions and assessing the virological responses to therapy.
Chevaliez, Stéphane, Pawlotsky, Jean-Michel   +1 more
openaire   +3 more sources

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Elevated anti-Zta IgG levels and EBV viral load are associated with site of tumor presentation in endemic Burkitt's lymphoma patients: a case control study

Infectious Agents and Cancer, 2010
Background Endemic Burkitt's lymphoma (BL) is an extranodal tumor appearing predominantly in the jaw in younger children while abdominal tumors predominate with increasing age.
Lanar David E, Dutta Sheetij, Long Carole, Middeldorp Jaap M, Fiore Nancy, Odada Peter, Piriou Erwan, Asito Amolo S, Jura Walter G, Ouma Collins, Otieno Juliana A, Moormann Ann M, Rochford Rosemary   +12 more
doaj   +1 more source

Hemagglutination with Adenoviruses. Nature of Viral Antigen

Experimental Biology and Medicine, 1958
SummaryA rise in antibodies to types 1-4 of adenoviruses during illness can be detected in human serum by employing hemagglutination technics. Although the original method described does not measure an increase in antibodies directed against a single type of virus, type-specific antibodies can be titrated if serum is mixed with a pool of heterologous ...
Harold S. Ginsberg, Eugene Ross
openaire   +3 more sources