Results 41 to 50 of about 382,907 (311)

PATTERN-RECOGNIZING RECEPTORS AND THE INNATE IMMUNE RESPONSE TO VIRAL INFECTION

Journal of V. N. Karazin Kharkiv National University: Series Medicine, 2019
The innate immune response to viral pathogens is crucial in mobilizing defensive reactions of an organism during the development of an acute viral infection.
Ksenia Veklich
doaj   +1 more source

Absence of CTL Responses to Early Viral Antigens Facilitates Viral Persistence [PDF]

The Journal of Immunology, 2008
Abstract CD8+ T cells are crucial for the control of intracellular pathogens such as viruses and some bacteria. Using lymphocytic choriomeningitis virus (LCMV) infection of mice—the prototypic arenavirus evolutionarily closely related to human Lassa fever and South American hemorrhagic fever viruses, we have shown previously that the ...
Schildknecht, A, Welti, S, Geuking, M B, Hangartner, L, van den Broek, Maries   +4 more
openaire   +3 more sources

Systematic collection, annotation, and pattern analysis of viral vaccines in the VIOLIN vaccine knowledgebase

Frontiers in Cellular and Infection Microbiology
BackgroundViral vaccines have been proven significant in protecting us against viral diseases such as COVID-19. To better understand and design viral vaccines, it is critical to systematically collect, annotate, and analyse various viral vaccines and ...
Anthony Huffman, Mehul Gautam, Arya Gandhi, Priscilla Du, Lauren Austin, Kallan Roan, Jie Zheng, Yongqun He, Yongqun He   +8 more
doaj   +1 more source

Provision of combined antiretroviral therapy in HIV-positive pregnant women and the increased risk of apoptosis-related intra-uterine growth restriction

HIV & AIDS Review. International Journal of HIV-Related Problems, 2019
Human immunodeficiency virus (HIV) infection during pregnancy is still a major problem worldwide, especially in developing countries. Although administration of anti-retroviral drugs has succeeded in reducing mother-to-child transmission, poor obstetric ...
Artana Putra IW, Ketut Suwiyoga
doaj   +1 more source

Persistent Herpes Simplex Virus Type 1 Infection of Enteric Neurons Triggers CD8+ T Cell Response and Gastrointestinal Neuromuscular Dysfunction

Frontiers in Cellular and Infection Microbiology, 2021
Behind the central nervous system, neurotropic viruses can reach and persist even in the enteric nervous system (ENS), the neuronal network embedded in the gut wall.
Paola Brun, Jessica Conti, Veronica Zatta, Venera Russo, Melania Scarpa, Andromachi Kotsafti, Andrea Porzionato, Raffaele De Caro, Marco Scarpa, Matteo Fassan, Arianna Calistri, Ignazio Castagliuolo   +11 more
doaj   +1 more source

Western and dot immunoblotting analysis of viral antigens and antibodies: application to murine hepatitis virus. [PDF]

, 1984
Viral proteins were separated by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) and transferred quantitatively to nitrocellulose by electroblotting in SDS-containing buffer.
Buchmeier, MJ, Knobler, RL, Talbot, PJ
core  

The Role of Invasive Procedures in the Treatment of Complicated Gastrointestinal Graft‐Versus‐Host Disease in Pediatric Patients

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Gastrointestinal graft‐versus‐host disease (GI GVHD) following hematopoietic stem cell transplant is typically managed with medical therapy, but surgery and angioembolization may be warranted in selected cases with life‐threatening complications.
Gaia Brunetti, Giorgio Persano, Chiara Grimaldi, Pier Luigi Di Paolo, Carmen Malaspina, Francesco Quagliarella, Valerio Balassone, Anna Chiara Iolanda Contini, Gian Luigi Natali, Rita Alaggio, Ivan Pietro Aloi, Tamara Caldaro, Alessandro Crocoli   +12 more
wiley   +1 more source

Functionally inactivated dominant viral antigens of human cytomegalovirus delivered in replication incompetent adenovirus type 6 vectors as vaccine candidates

Human Vaccines & Immunotherapeutics, 2017
T cell immunity is critical in controlling human cytomegalovirus (HCMV) infection in transplant recipients, and T cells targeting viral immediate early proteins such as IE1, IE2 and pp65 have been speculated to be more effective against reactivation ...
Aimin Tang, Daniel C. Freed, Fengsheng Li, Steve Meschino, Michael Prokop, Andrew Bett, Danilo Casimiro, Dai Wang, Tong-Ming Fu   +8 more
doaj   +1 more source

Kinetics of antibody-induced modulation of respiratory syncytial virus antigens in a human epithelial cell line

Virology Journal, 2007
Background The binding of viral-specific antibodies to cell-surface antigens usually results in down modulation of the antigen through redistribution of antigens into patches that subsequently may be internalized by endocytosis or may form caps that can ...
Gómez-Garcia Beatriz, Valverde Laura E, Tirado Rocio G, Sarmiento Rosa E   +3 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source