Results 31 to 40 of about 270,928 (312)

Multiplex RT-PCR amplification of HIV genes to create a completely autologous DC-based immunotherapy for the treatment of HIV infection. [PDF]

open access: yesPLoS ONE, 2008
BACKGROUND: Effective therapy for HIV-infected individuals remains an unmet medical need. Promising clinical trials with dendritic cell (DC)-based immunotherapy consisting of autologous DC loaded with autologous virus have been reported, however, these ...
Irina Tcherepanova   +8 more
doaj   +1 more source

Persistence of SARS-CoV-2 Antigens in the Nasal Mucosa of Eight Patients with Inflammatory Rhinopathy for over 80 Days following Mild COVID-19 Diagnosis

open access: yesViruses, 2023
The nasal mucosa is the main gateway for entry, replication and elimination of the SARS-CoV-2 virus, the pathogen that causes severe acute respiratory syndrome (COVID-19).
Juliana Costa dos Santos   +8 more
doaj   +1 more source

PATTERN-RECOGNIZING RECEPTORS AND THE INNATE IMMUNE RESPONSE TO VIRAL INFECTION

open access: yesJournal of V. N. Karazin Kharkiv National University: Series Medicine, 2019
The innate immune response to viral pathogens is crucial in mobilizing defensive reactions of an organism during the development of an acute viral infection.
Ksenia Veklich
doaj   +1 more source

Plasmacytoid dendritic cells capture and cross-present viral antigens from influenza-virus exposed cells. [PDF]

open access: yesPLoS ONE, 2009
Among the different subsets of dendritic cells (DC), plasmacytoid dendritic cells (PDC) play a unique role in secreting large amounts of type I interferons upon viral stimulation, but their efficiency as antigen-presenting cells has not been completely ...
Gabrielle Lui   +5 more
doaj   +1 more source

Systematic collection, annotation, and pattern analysis of viral vaccines in the VIOLIN vaccine knowledgebase

open access: yesFrontiers in Cellular and Infection Microbiology
BackgroundViral vaccines have been proven significant in protecting us against viral diseases such as COVID-19. To better understand and design viral vaccines, it is critical to systematically collect, annotate, and analyse various viral vaccines and ...
Anthony Huffman   +8 more
doaj   +1 more source

Provision of combined antiretroviral therapy in HIV-positive pregnant women and the increased risk of apoptosis-related intra-uterine growth restriction

open access: yesHIV & AIDS Review. International Journal of HIV-Related Problems, 2019
Human immunodeficiency virus (HIV) infection during pregnancy is still a major problem worldwide, especially in developing countries. Although administration of anti-retroviral drugs has succeeded in reducing mother-to-child transmission, poor obstetric ...
Artana Putra IW, Ketut Suwiyoga
doaj   +1 more source

From Superantigens to “Real” Viral Antigens [PDF]

open access: yesViral Immunology, 2020
Studies inspired by Dr. Peter Doherty led to over 16 years of research into the mouse gamma-herpesvirus, γHV68, in the Blackman laboratory. Progress on our understanding of γHV68 biology include insight into the establishment of latency, immune control of the acute and latent stages of infection and experimental vaccines, is described here.
openaire   +2 more sources

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli   +3 more
wiley   +1 more source

Functionally inactivated dominant viral antigens of human cytomegalovirus delivered in replication incompetent adenovirus type 6 vectors as vaccine candidates

open access: yesHuman Vaccines & Immunotherapeutics, 2017
T cell immunity is critical in controlling human cytomegalovirus (HCMV) infection in transplant recipients, and T cells targeting viral immediate early proteins such as IE1, IE2 and pp65 have been speculated to be more effective against reactivation ...
Aimin Tang   +8 more
doaj   +1 more source

Kinetics of antibody-induced modulation of respiratory syncytial virus antigens in a human epithelial cell line

open access: yesVirology Journal, 2007
Background The binding of viral-specific antibodies to cell-surface antigens usually results in down modulation of the antigen through redistribution of antigens into patches that subsequently may be internalized by endocytosis or may form caps that can ...
Gómez-Garcia Beatriz   +3 more
doaj   +1 more source

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