Results 51 to 60 of about 960,547 (305)
Human Vaccines & Immunotherapeutics, 2017 T cell immunity is critical in controlling human cytomegalovirus (HCMV) infection in transplant recipients, and T cells targeting viral immediate early proteins such as IE1, IE2 and pp65 have been speculated to be more effective against reactivation ...
Aimin Tang +8 more
doaj +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Virology Journal, 2007 Background The binding of viral-specific antibodies to cell-surface antigens usually results in down modulation of the antigen through redistribution of antigens into patches that subsequently may be internalized by endocytosis or may form caps that can ...
Gómez-Garcia Beatriz +3 more
doaj +1 more source
Frontiers in Cellular and Infection Microbiology, 2021 Behind the central nervous system, neurotropic viruses can reach and persist even in the enteric nervous system (ENS), the neuronal network embedded in the gut wall.
Paola Brun +11 more
doaj +1 more source
Constrained pattern of viral evolution in acute and early HCV infection limits viral plasticity [PDF]
, 2011 Cellular immune responses during acute Hepatitis C virus (HCV) and HIV infection are a known correlate of infection outcome. Viral adaptation to these responses via mutation(s) within CD8+ T-cell epitopes allows these viruses to subvert host immune ...
Paul Klenerman +53 more
core +3 more sources
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
A nonstructural viral protein expressed by a recombinant vaccinia virus protects against lethal cytomegalovirus infection [PDF]
, 1988 The nonstructural immediate-early protein pp89 of murine cytomegalovirus (MCMV) is the first viral protein synthesized after infection and has a regulatory function in viral gene expression. Despite its localization in the nucleus of infected cells, pp89
Reddehase, Matthias J. +4 more
core +1 more source
Ebola virus-mediated T-lymphocyte depletion is the result of an abortive infection.
PLoS Pathogens, 2019 Ebola virus (EBOV) infections are characterized by a pronounced lymphopenia that is highly correlative with fatalities. However, the mechanisms leading to T-cell depletion remain largely unknown.
Patrick Younan +11 more
doaj +1 more source
Innate Viral Receptor Signaling Determines Type 1 Diabetes Onset
Frontiers in Endocrinology, 2017 Heritable susceptibility of the autoimmune disorder, type 1 diabetes (T1D), only partially equates for the incidence of the disease. Significant evidence attributes several environmental stressors, such as vitamin D deficiency, gut microbiome, dietary ...
Zachary J. Morse, Marc S. Horwitz
doaj +1 more source
, 2016 Laboratorians continually seek methodologies that yield accurate results in a timely fashion, are cost effective, and require less technical expertise. Diagnosis of viral infections via viral antigen detection methods such as immunofluorescence (FA), immunochromatography (lateral flow) (IC), and enzyme immunoassays (EIA) offer many of these attractive ...
Diane S. Leland, Ryan F. Relich
openaire +1 more source