Results 11 to 20 of about 258,807 (267)

SARS-CoV-2 Gut-Targeted Epitopes: Sequence Similarity and Cross-Reactivity Join Together for Molecular Mimicry

Biomedicines, 2023
The gastrointestinal tract can be heavily infected by SARS-CoV-2. Being an auto-immunogenic virus, SARS-CoV-2 represents an environmental factor that might play a role in gut-associated autoimmune diseases.
Aaron Lerner, Carina Benzvi, Aristo Vojdani   +2 more
doaj   +1 more source

Identification of presented SARS-CoV-2 HLA class I and HLA class II peptides using HLA peptidomics

Cell Reports, 2021
Summary: The human leukocyte antigen (HLA)-bound viral antigens serve as an immunological signature that can be selectively recognized by T cells. As viruses evolve by acquiring mutations, it is essential to identify a range of presented viral antigens ...
Adi Nagler, Shelly Kalaora, Chaya Barbolin, Anastasia Gangaev, Steven L.C. Ketelaars, Michal Alon, Joy Pai, Gil Benedek, Yfat Yahalom-Ronen, Noam Erez, Polina Greenberg, Gal Yagel, Aviyah Peri, Yishai Levin, Ansuman T. Satpathy, Erez Bar-Haim, Nir Paran, Pia Kvistborg, Yardena Samuels   +18 more
doaj   +1 more source

Immunoelectron Microscopy of Viral Antigens [PDF]

Current Protocols in Microbiology, 2019
AbstractImmunoelectron microscopy is a powerful technique for identifying viral antigens and determining their structural localization and organization within vaccines and viruses. While traditional negative staining transmission electron microscopy provides structural information, identity of components within a sample may be confounding ...
Gulati, Neetu M., Torian, Udana, Gallagher, John R., Harris, Audray K.   +3 more
openaire   +2 more sources

How Does HTLV-1 Undergo Oncogene-Dependent Replication Despite a Strong Immune Response?

Frontiers in Microbiology, 2018
In 1987, Mitsuaki Yoshida proposed the following model (Yoshida and Seiki, 1987): “... T-cells activated through the endogenous p40x would express viral antigens including the envelope glycoproteins which are exposed on the cell surface.
Hélène Gazon, Hélène Gazon, Pradeep Chauhan, Pradeep Chauhan, Malik Hamaidia, Malik Hamaidia, Clotilde Hoyos, Clotilde Hoyos, Lin Li, Lin Li, Roghaiyeh Safari, Roghaiyeh Safari, Luc Willems, Luc Willems   +13 more
doaj   +1 more source

Sequestration of Late Antigens Within Viral Factories Impairs MVA Vector-Induced Protective Memory CTL Responses

Frontiers in Immunology, 2019
Cytotoxic CD8+ T cell (CTL) responses play an essential role in antiviral immunity. Here, we focused on the activation of CTL which recognize epitopes derived from viral or recombinant antigens with either early or late expression kinetics after ...
Sha Tao, Ronny Tao, Dirk H. Busch, Marek Widera, Heiner Schaal, Ingo Drexler   +5 more
doaj   +1 more source

Increased Immunogenicity of Full-Length Protein Antigens through Sortase-Mediated Coupling on the PapMV Vaccine Platform

Vaccines, 2019
Background: Flexuous rod-shape nanoparticles—made of the coat protein of papaya mosaic virus (PapMV)—provide a promising vaccine platform for the presentation of viral antigens to immune cells.
Marie-Ève Laliberté-Gagné, Marilène Bolduc, Ariane Thérien, Caroline Garneau, Philippe Casault, Pierre Savard, Jérome Estaquier, Denis Leclerc   +7 more
doaj   +1 more source

Histocompatibility antigens in viral warts

Acta Dermato-Venereologica, 1982
One hundred patients with viral warts and 108 apparently healthy matched controls were typed for HLA-A and B antigens. No significant difference in the frequencies of antigens was revealed, which suggested that a possible genetic trend in warts is at least not related to A and B loci of the histocompatibility system.
R, Friedman-Birnbaum, S, Haim, A, Sheinkman, O, Gideone, A, Barzilai   +4 more
openaire   +2 more sources

Treating cancer as an infectious disease--viral antigens as novel targets for treatment and potential prevention of tumors of viral etiology. [PDF]

PLoS ONE, 2007
Nearly 20% of human cancers worldwide have an infectious etiology with the most prominent examples being hepatitis B and C virus-associated hepatocellular carcinoma and human papilloma virus-associated cervical cancer. There is an urgent need to find new
Xing Guo Wang, Ekaterina Revskaya, Ruth A Bryan, Howard D Strickler, Robert D Burk, Arturo Casadevall, Ekaterina Dadachova   +6 more
doaj   +1 more source

Features of IgG-antibodies production to individual Cytomegalovirus proteins in various eye diseases (age-related macular degeneration and central serous chorioretinopathy)

Инфекция и иммунитет, 2021
Age-related macular degeneration (AMD) and central serous chorioretinopathy (CSC) are diseases targeting the posterior segment of the eye that often lead to lowered visual functions. Pathogenesis of such disorders largely remains unclear.
V. V. Neroev, G. I. Krichevskaya, G. I. Alatortseva, M. V. Ryabina, A. P. Sarygina, L. N. Nesterenko, V. V. Dotsenko, L. N, Luhverchik   +7 more
doaj   +1 more source

Polymorphism and Selection Pressure of SARS-CoV-2 Vaccine and Diagnostic Antigens: Implications for Immune Evasion and Serologic Diagnostic Performance

Pathogens, 2020
The ongoing SARS-CoV-2 pandemic has triggered multiple efforts for serological tests and vaccine development. Most of these tests and vaccines are based on the Spike glycoprotein (S) or the Nucleocapsid (N) viral protein.
Eric Dumonteil, Claudia Herrera
doaj   +1 more source