Results 121 to 130 of about 2,037,182 (315)

Exposure to Abnormal Self Antigens During Non-Malignant Inflammatory Events Provides Immunological Defense Against Tumors [PDF]

, 2013
Cancer immunosurveillance is the body’s sentinel mechanism of recognizing and eliminating malignancy. Specifically, the immune system can mount a response against cancer through the recognition of tumor associated antigens (TAA). While studying two TAAs,
Iheagwara, Uzoma
core  

Identification and validation of viral antigens sharing sequence and structural homology with tumor-associated antigens (TAAs).

, 2021
Background The host’s immune system develops in equilibrium with both cellular self-antigens and non-self-antigens derived from microorganisms which enter the body during lifetime. In addition, during the years, a tumor may arise presenting to the immune
Maria Lina Tornesello, Carmen Manolio, Angela Mauriello, Filippo Castiglione, Concetta Ragone, Emanuela Iaccarino, Franco M Buonaguro, Menotti Ruvo, Maria Tagliamonte, Beatrice Cavalluzzo, Luigi Vitagliano, Luigi Buonaguro, Cavalluzzo B, Ragone, Concetta, Manolio C, Tagliamonte M, Cavalluzzo, Beatrice, Buonaguro FM, Vitagliano L, Vitagliano, Luigi, Mauriello A, Ruvo M, Buonaguro, Franco M, Iaccarino, Emanuela, Tornesello, Maria Lina, Tornesello ML, Castiglione, Filippo, Tagliamonte, Maria, Manolio, Carmen, Ruvo, Menotti, Iaccarino E, Castiglione F, Mauriello, Angela, Buonaguro, Luigi, Buonaguro L, Ragone C, Ragone, C., Mauriello, A., Laccarino, E., Castiglione, F., Manolio, C., Vitagliano, L., Tornesello, M. L., Tagliamonte, M., Cavalluzzo, B., Ruvo, M., Buonaguro, L., Buonaguro, F.   +47 more
core   +1 more source

Expansion of host range as a driving force in the evolution of Toxoplasma

Memorias do Instituto Oswaldo Cruz, 2009
The apicomplexan parasite Toxoplasma gondii is unusual in being able to infect almost any cell from almost any warm-blooded animal it encounters. This extraordinary host-range contrasts with its far more particular cousins such as the various species of ...
John C Boothroyd
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

CD8+ T-cell responses to Theileria parva are preferentially directed to a single dominant antigen:Implications for parasite strain-specific immunity [PDF]

, 2009
Although immunodominance of CD8(+) T-cell responses is a well-recognised feature of viral infections, its role in responses to more antigenically complex pathogens is less clear.
Connelley, T., Burrells, A, W. Ivan Morrison, Declan J. McKeever, Connelley, Timothy, Taracha, Evans L., Connelly, T, McKeever, DJ, Morrison, WI, Simon P. Graham, Burrells, A., MacHugh, ND, McKeever, D J, Taracha, E.L.N., Niall D. MacHugh, Roger Pelle, Ellis, SA, McKeever, Declan J., MacHugh, N D, Connelley, T, Evans L. Taracha, Ellis, S A, Graham, SP, Pelle, Roger, Ellis, Shirley A., MacHugh, Niall D., Formisano, Principia, Formisano, P, Principia Formisano, Taracha, EL, Ellis, S.A., Shirley A. Ellis, Taracha, E L, Alison Burrells, Pelle, R, Graham, Simon P., Graham, S P, Timothy Connelley, Formisano, P., Morrison, W. Ivan, Burrells, Alison, Graham, S.P.   +41 more
core   +1 more source

Analysis of expressed sequence tags from Trypanosoma cruzi amastigotes

Memorias do Instituto Oswaldo Cruz, 2005
A total of 880 expressed sequence tags (EST) originated from clones randomly selected from a Trypanosoma cruzi amastigote cDNA library have been analyzed.
Gustavo C Cerqueira, Wanderson D DaRocha, Priscila C Campos, Cláudia S Zouain, Santuza MR Teixeira   +4 more
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Limited antigenic diversity of Plasmodium falciparumapical membrane antigen 1 supports the development of effective multi-allele vaccines [PDF]

, 2014
Background: Polymorphism in antigens is a common mechanism for immune evasion used by many important pathogens, and presents major challenges in vaccine development. In malaria, many key immune targets and vaccine candidates show substantial polymorphism.
Drew, Damien R., Sheetij Dutta, Senn, Nicolas, Hodder, AN, Dutta, Sheetij, Nicolas Senn, Osier, Faith H. A., Terheggen, Ulrich, Damien R Drew, Beeson, JG, Nadia J Cross, James G Beeson, Osier, FHA, Alyssa E Barry, Ulrich Terheggen, Hodder, Anthony N., Mueller, I, Siba, PM, Drew, DR, Stanisic, Danielle I., Terheggen, U, Anders, RF, Beeson, James G., Peter M Siba, Dutta, S, Cross, Nadia J., Kevin Marsh, Faith HA Osier, Barry, AE, Jack S Richards, Anders, Robin F., Barry, Alyssa E., Elliott, Salenna R., Senn, N, Danielle I Stanisic, Stanisic, DI, Mueller, Ivo, Ivo Mueller, Marsh, K, Elliott, SR, Richards, Jack S., Anthony N Hodder, Mugyenyi, Cleopatra K., Cleopatra K Mugyenyi, Osier, Faith, Richards, JS, Robin F Anders, Cross, NJ, Salenna R Elliott, Marsh, Kevin, Mugyenyi, CK, Siba, Peter M.   +51 more
core   +2 more sources

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Luminal Bacteria Recruit CD103+ Dendritic Cells into the Intestinal Epithelium to Sample Bacterial Antigens for Presentation

Immunity, 2013
SUMMARY CD103+ dendritic cells (DCs) carry bacteria from the small intestine and can present antigens to T cells. Yet they have not been recorded sampling luminal bacteria or presenting bacterial antigens in mesentery lymph nodes.
J. Farache, I. Koren, Idan Milo, Irina Gurevich, Ki-Wook Kim, E. Zigmond, G. Furtado, S. Lira, G. Shakhar   +8 more
semanticscholar   +1 more source