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An Improved and Scalable Process for the Synthesis of Ezetimibe: An Antihypercholesterolemia Drug
Organic Process Research & Development, 2009An efficient, cost-effective and large-scale synthesis of ezetimibe 1, an antihypercholesterolemia drug, is described. Chiral oxazolidinone chemistry was used to fix the required stereochemistry of the β-lactam ring, and the chiral oxazaborolidine chemistry was used to fix the hydroxyl group stereochemistry.
C. H. V. A. Sasikala +6 more
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Synthesis, 2010
A convenient and efficient total synthesis of ezetimibe, an intestinal cholesterol absorption inhibitor and useful anticholesteremic agent, is described. Based on (Z)-5-(4-fluorophenyl)pent-4-enoic acid as a starting compound, and taking the synthesis through further Z-configured intermediates, the total yield is remarkably increased, compared with the
Stanislav Gobec +5 more
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A convenient and efficient total synthesis of ezetimibe, an intestinal cholesterol absorption inhibitor and useful anticholesteremic agent, is described. Based on (Z)-5-(4-fluorophenyl)pent-4-enoic acid as a starting compound, and taking the synthesis through further Z-configured intermediates, the total yield is remarkably increased, compared with the
Stanislav Gobec +5 more
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Effect of cnidium monnieri (L.) cuss on antihypercholesterolemia
European Journal of Pharmacology, 1990A.G. Wang, W.S. Wang, J.L. Wang
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