Results 1 to 10 of about 17,598 (157)
The Use of Statins in Parkinson's and Alzheimer's Disease: A 2021-2025 State-of-the-Art Review of Clinical and Preclinical Evidence. [PDF]
Pharmacol Res PerspectABSTRACT Statins, widely prescribed for cardiovascular prevention, have emerged as potential disease‐modifying agents in neurodegenerative disorders due to their pleiotropic effects on cholesterol metabolism, neuroinflammation, oxidative stress, and protein aggregation.
Chiatto LM +7 more
europepmc +2 more sources
Simvastatin Restores Cisplatin Sensitivity by Suppressing the Caveolin-1-Mediated PI3K/AKT Signaling Pathway in Cisplatin-Resistant Cervical Cancer Cells. [PDF]
FASEB JSimvastatin synergizes with cisplatin in cisplatin‐resistant cervical cancer cells through suppression of the caveolin‐1‐mediated PI3K/AKT signaling axis. ABSTRACT Cervical cancer treatment is often hindered by the emergence of cisplatin (DDP) resistance. Increasing evidence has indicated that statins possess anti‐tumor and chemosensitization potential
Zhou Y +7 more
europepmc +2 more sources
, 2022 Lovastatin is a naturally produced 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase enzyme inhibitor- used for treating hypercholesterolemia.
Chadhurthika Krishnamurthy +5 more
core +1 more source
Improved dissolution rate and oral bioavailability of lovastatin in red yeast rice products
, 2014 Lovastatin, categorized as a class II compound according to the Biopharmaceutics Classification System, is mainly responsible for the blood cholesterol lowering effect of red yeast rice (RYR).
Chen, Chia-Hao;Yang, Jyh-Chin;Uang, Yow-Shieng;Lin, Chun-Jung +1 more
core +1 more source
, 2012 Lovastatin exhibits higher thermal stability and lower degradation rate than simvastatin. However, the amount of research studying a lovastatin delivery device has been far less than similar research on simvastatin.
何明樺;江俊斌;劉耀方;郭彥彬;林思洸;賴君義;李伯訓 +1 more
core +1 more source
, 2017 Chronic periodontitis is characterized by inflammation of periodontal tissues, leading to bone resorption and tooth loss. The goal of treatment is to regenerate periodontal tissues including bone and cementum lost as a consequence of disease.
Lee, Bor-Shiunn;Lee, Chien-Chen;Wang, Yi-Ping;Chen, Hsiao-Jan;Lai, Chern-Hsiung;Hsieh, Wan-Ling;Chen, Yi-Wen +1 more
core +1 more source
Is quorum sensing involved in lovastatin production in the filamentous fungus Aspergillus terreus?
, 2012 A novel role for butyrolactone I as a quorum sensing molecule in the filamentous fungus Aspergillus terreus is proposed based on its ability to affect both lovastatin and its own production. In this work, the exogenous addition of 100 nM butyrolactone I
Raina, S. +6 more
core +1 more source
Impact of linoleic acid supplementation on lovastatin production in Aspergillus terreus cultures
, 2010 This work proposes a novel approach for enhancing the yield of lovastatin in Aspergillus terreus cultures by exploiting linoleic acid-derived signalling molecules, which are potentially involved in fungal cell– cell communication.
Roy, I., Keshavarz, T., Sorrentino, F.
core +1 more source
British Journal of Clinical Pharmacology, EarlyView.Abstract Purpose To quantify how often creatine kinase (CK) is measured after newly elevated aminotransferases in statin users, and whether absent CK data are associated with gastroenterology (GI) referrals. Methods Retrospective chart review of adult outpatients on statins with a first alanine/aspartate aminotransferase (ALT/AST) elevation during a 5 ...
Faris Shweikeh +5 more
wiley +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Statin‐associated muscle symptoms (SAMS) are frequent adverse effects of statin therapy and have been hypothesized to result from impaired coenzyme Q10 (CoQ10) biosynthesis. Although genetic determinants of CoQ10 levels have been reported, genome‐wide association studies (GWASs) conducted specifically in statin users are lacking. Moreover, direct CoQ10
Da Hoon Lee +6 more
wiley +1 more source