Results 11 to 20 of about 31,024 (202)

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles. [PDF]

, 2017
Treatment of dyslipidemia patients with lipid-lowering drugs leads to a significant reduction in low-density lipoproteins (LDL) level and a low to moderate level of increase in high-density lipoprotein (HDL) cholesterol in plasma.
Alderete, Benjamin, Amento, Edward P, Kong, Raymond, Liu, David, Lundry, Jason, Madasamy, Shanmugavel, Robinson, J Paul, Wu, Alan HB   +7 more
core   +1 more source

Besnoitia besnoiti infection alters both endogenous cholesterol de novo synthesis and exogenous LDL uptake in host endothelial cells [PDF]

, 2019
Besnoitia besnoiti, an apicomplexan parasite of cattle being considered as emergent in Europe, replicates fast in host endothelial cells during acute infection and is in considerable need for energy, lipids and other building blocks for offspring ...
Failing, Klaus, Hamid, Penny, Hermosilla, Carlos, Kerner, Katharina, Larrazabal, Camilo, Lütjohann, Dieter, Silva, Liliana M. R., Taubert, Anja, Velasquez, Zahady D.   +8 more
core   +2 more sources

A staged screening of registered drugs highlights remyelinating drug candidates for clinical trials [PDF]

, 2017
There is no treatment for the myelin loss in multiple sclerosis, ultimately resulting in the axonal degeneration that leads to the progressive phase of the disease.
Agresti, C., Buscarinu, Maria Chiara, Calo', Giorgia, Eleuteri, Cecilia, Ferrari, F., Mechelli, Rosella, Olla, S., Ristori, Giovanni, Romano, Silvia, Salvetti, Marco, Umeton, Renato, Veroni, Chiara   +11 more
core   +2 more sources

Pengaruh Saccharomyces cerevisiae terhadap kadar lovastatin dalam angkak yang dihasilkan dari fermentasi beras oleh Monascus purpureus jmbA

Journal of Biological Researches, 2012
Fermented rice by Monascus purpureus, namely angkak, produces lovastatin. Lovastatin has been believed and studied as anti hypercholesterolemic agent.
Evi Triana, Novik Nurhidayat
doaj   +1 more source

Pitavastatin and Lovastatin Exhibit Calcium Channel Blocking Activity Which Potentiate Vasorelaxant Effects of Amlodipine: A New Futuristic Dimension in Statin’s Pleiotropy

Medicina, 2023
Background and Objectives: We have recently reported that Fluvastatin, Atorvastatin, Simvastatin and Rosuvastatin have calcium channel antagonistic activities using rabbits’ intestinal preparations.
Wajid Ali, Niaz Ali, Abid Ullah, Shafiq Ur Rahman, Shujaat Ahmad   +4 more
doaj   +1 more source

Should Research Ethics Encourage the Production of Cost-Effective Interventions? [PDF]

, 2016
This project considers whether and how research ethics can contribute to the provision of cost-effective medical interventions. Clinical research ethics represents an underexplored context for the promotion of cost-effectiveness.
A Briggs, A Fleischman, A Rid, AD Paltiel, AJ London, AJ London, AM Garber, AS Kesselheim, C Grady, CC Denny, D Barnbaum, D Mortimer, D Wendler, DA Hyman, DB Resnik, DJ Torgerson, DM Dimichele, DR Buchanan, E Frank, ED Prentice, EE Roughead, EJ Emanuel, EJ Emanuel, EJ Emanuel, EJ Emanuel, EJ Emanuel, F Baylis, FA Lederle, G Yamey, GA Cohen, GR Wilensky, H Grabowski, HF Lynch, HG Frankfurt, HJ Curzer, I Rudan, J Cohen, J Dowie, J Harris, J McMahan, JA Tobert, JC Lindsey, JW Berg, L Bojke, LP Garrison Jr, M Angell, M Limb, MF Drummond, MJ Mehlman, MS Mano, N Daniels, NMP King, NMP King, PA Ubel, PJ Neumann, PJ Neumann, PR Orszag, PR Orszag, PT Menzel, PT Menzel, PT Menzel, R Dresser, RA Epstein, RA Rettig, RA Spinello, RK Lie, RL Fleurence, S Batt, S Joffe, S Palmer, S Thomson, S Woods, SE Weinberger, SK Shah, T Fojo, T Hurka, T Schrecker, TJ Zywicki, U Schüklenk, WC Black, Z Kmietowicz   +80 more
core   +1 more source

Lovastatin enhances adenovirus-mediated TRAIL induced apoptosis by depleting cholesterol of lipid rafts and affecting CAR and death receptor expression of prostate cancer cells [PDF]

, 2014
Oncolytic adenovirus and apoptosis inducer TRAIL are promising cancer therapies. Their antitumor efficacy, when used as single agents, is limited. Oncolytic adenoviruses have low infection activity, and cancer cells develop resistance to TRAIL-induced ...
Chen, Lin, Gong, Zhicheng, Hock, Janet M., Kao, Chinghai, Li, Xiong, Liu, Youhong, Shen, Liangfang, Sun, Lunquan   +7 more
core   +10 more sources

Lovastatin protects against experimental plague in mice. [PDF]

PLoS ONE, 2010
BACKGROUND: Plague is an ectoparasite-borne deadly infection caused by Yersinia pestis, a bacterium classified among the group A bioterrorism agents. Thousands of deaths are reported every year in some African countries.
Saravanan Ayyadurai, Hubert Lepidi, Claude Nappez, Didier Raoult, Michel Drancourt   +4 more
doaj   +1 more source

Role of cholesterol synthesis in regulation of bile acid synthesis and biliary cholesterol secretion in humans.

Journal of Lipid Research, 1991
We used lovastatin, a specific inhibitor of HMG-CoA reductase, to study the role of cholesterol synthesis in regulation of both bile acid synthesis, measured by release of 14CO2 from [26-14C]cholesterol, and biliary cholesterol secretion, measured by ...
JC Mitchell, BG Stone, GM Logan, WC Duane   +3 more
doaj   +1 more source

In Vivo and in Vitro Study on Drug-Drug Interaction of Lovastatin and Berberine from Pharmacokinetic and HepG2 Cell Metabolism Studies

Molecules, 2016
Background: We assumed that the pharmacokinetics of lovastatin could be changed by the induction effect of berberine. Methods: An UPLC-MS/MS method was developed and validated for the pharmacokinetics tudy of lovastatin to investigate the in vivo drug ...
Hanming Cui, Jialong Wang, Qiuyan Zhang, Mengmeng Dang, Hui Liu, Yu Dong, Lu Zhang, Fang Yang, Jianhua Wu, Xiaolin Tong   +9 more
doaj   +1 more source