Results 11 to 20 of about 15,201 (138)

Pengaruh Saccharomyces cerevisiae terhadap kadar lovastatin dalam angkak yang dihasilkan dari fermentasi beras oleh Monascus purpureus jmbA

Journal of Biological Researches, 2012
Fermented rice by Monascus purpureus, namely angkak, produces lovastatin. Lovastatin has been believed and studied as anti hypercholesterolemic agent.
Evi Triana, Novik Nurhidayat
doaj   +1 more source

Role of cholesterol synthesis in regulation of bile acid synthesis and biliary cholesterol secretion in humans.

Journal of Lipid Research, 1991
We used lovastatin, a specific inhibitor of HMG-CoA reductase, to study the role of cholesterol synthesis in regulation of both bile acid synthesis, measured by release of 14CO2 from [26-14C]cholesterol, and biliary cholesterol secretion, measured by ...
JC Mitchell, BG Stone, GM Logan, WC Duane   +3 more
doaj   +1 more source

In Vivo and in Vitro Study on Drug-Drug Interaction of Lovastatin and Berberine from Pharmacokinetic and HepG2 Cell Metabolism Studies

Molecules, 2016
Background: We assumed that the pharmacokinetics of lovastatin could be changed by the induction effect of berberine. Methods: An UPLC-MS/MS method was developed and validated for the pharmacokinetics tudy of lovastatin to investigate the in vivo drug ...
Hanming Cui, Jialong Wang, Qiuyan Zhang, Mengmeng Dang, Hui Liu, Yu Dong, Lu Zhang, Fang Yang, Jianhua Wu, Xiaolin Tong   +9 more
doaj   +1 more source

Lovastatin protects against experimental plague in mice. [PDF]

PLoS ONE, 2010
BACKGROUND: Plague is an ectoparasite-borne deadly infection caused by Yersinia pestis, a bacterium classified among the group A bioterrorism agents. Thousands of deaths are reported every year in some African countries.
Saravanan Ayyadurai, Hubert Lepidi, Claude Nappez, Didier Raoult, Michel Drancourt   +4 more
doaj   +1 more source

Utilization of an Industry Byproduct, Corymbia maculata Leaves, by Aspergillus terreus to Produce Lovastatin

Bioengineering, 2020
Due to its ability to lower cholesterol levels, simvastatin is a leading drug for the prevention of strokes and heart disease: it also lowers the incidence of neurodegenerative diseases.
Mishal Subhan, Rani Faryal, Ian Macreadie   +2 more
doaj   +1 more source

Lovastatin induces multiple stress pathways including LKB1/AMPK activation that regulate its cytotoxic effects in squamous cell carcinoma cells. [PDF]

PLoS ONE, 2012
Cellular stress responses trigger signaling cascades that inhibit proliferation and protein translation to help alleviate the stress or if the stress cannot be overcome induce apoptosis.
Laurie Ma, Nima Niknejad, Ivan Gorn-Hondermann, Khalil Dayekh, Jim Dimitroulakos   +4 more
doaj   +1 more source

Lovastatin production by an oleaginous fungus, Aspergillus terreus KPR12 using sago processing wastewater (SWW)

Microbial Cell Factories, 2022
Background Lovastatin is one of the first statins to be extensively used for its cholesterol-lowering ability. It is commercially produced by fermentation.
Naganandhini Srinivasan, Kiruthika Thangavelu, Sivakumar Uthandi   +2 more
doaj   +1 more source

Lovastatin treatment inhibits sterol synthesis and induces HMG-CoA reductase activity in mononuclear leukocytes of normal subjects.

Journal of Lipid Research, 1989
The mechanism by which competitive inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase decrease serum cholesterol is incompletely understood.
B G Stone, C D Evans, W F Prigge, W C Duane, R L Gebhard   +4 more
doaj   +1 more source

EFFECT OF PARTIAL PURIFIED LOVASTATIN FROM ASPERGILLUS TERREUS A50 ON LIPID PROFILE AND LIVER ENZYMES IN VIVO

The Iraqi Journal of Agricultural science, 2022
This study was designed to determine the effect of partial purified lovastatin on the lipid profile and liver functions in rabbits. The rabbits were divided into six groups, each group containing four rabbits, and the lipid profile and liver functions ...
A.J. Al-Sa’ady, G. M. Aziz, M. J. Al-Obaidi   +2 more
doaj   +1 more source

Identification of lovastatin production in Aspergillus terreus strain (KF971363.1) and its antifungal role

Pakistan Journal of Pharmaceutical Sciences
Lovastatin has received interest for its potential therapeutic use in treating numerous diseases, for example, the blood cholesterol level by restraining hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase.
Aasma Khalid, Fatima Ismail
doaj   +1 more source