Transgelin 2 participates in lovastatin-induced anti-angiogenic effects in endothelial cells through a phosphorylated myosin light chain-related mechanism. [PDF]
PLoS ONE, 2012 BACKGROUND: Anti-angiogenic activity is considered to play a key role in the statin-induced anti-tumor effects. We aimed to identify new targets underlying this pleiotropic effect of lovastatin.
Yuan Xiao +5 more
doaj +1 more source
Manipulation of lipid rafts in neuronal cells [PDF]
, 2010 Lipid rafts are specialized plasma membrane micro-domains highly enriched in cholesterol, sphingolipids and glycosylphosphatidylinositol (GPI) anchored proteins.
Eckert, Gunter P.
core +1 more source
Effects of lovastatin therapy on guinea pig low density lipoprotein composition and metabolism.
Journal of Lipid Research, 1989 Lovastatin therapy is known to induce hepatic low density lipoprotein (LDL) receptor mRNA and LDL receptor activity. Yet, in studies in humans and animals it has been difficult to demonstrate an enhancement of the plasma fractional catabolic rate (FCR ...
L Berglund +3 more
doaj +1 more source
Assessment of extracts from red yeast rice for herb-drug interaction by in-vitro and in-vivo assays [PDF]
, 2012 Red yeast rice (RYR) is made by fermenting the yeast Monascus purpureus over rice. It is a source of natural red food colorants, a food garnish and a traditional medication.
Fung, W.T. +4 more
core +2 more sources
Metabolism and Metabolic Inhibition of Xanthotoxol in Human Liver Microsomes [PDF]
, 2016 Cytochrome p450 (CYP450) enzymes are predominantly involved in Phase I metabolism of xenobiotics. In this study, the CYP450 isoforms involved in xanthotoxol metabolism were identified using recombinant CYP450s.
Cai, Jiqun +5 more
core +9 more sources
Journal of Agriculture and Food ResearchLovastatin is a naturally occurring secondary metabolite. It has garnered significant attention due to its potent cholesterol-lowering property, mainly achieved through the inhibition of HMG-CoA reductase. This review explores the multifaceted aspects of
Chapa Ramasinghe, Baojun Xu
doaj +1 more source
Oxamniquine, praziquantel and lovastatin association in the experimental Schistosomiasis mansoni
Memorias do Instituto Oswaldo Cruz, 2008 The activity of lovastatin associated with oxamniquine or praziquantel against schistosomiasis mansoni was evaluated in mice infected with Schistosoma mansoni.
Neusa Araújo +4 more
doaj +1 more source
Statin Use and Risk of Prostate Cancer : A Meta-Analysis of Observational Studies [PDF]
, 2012 Background: Emerging evidence suggests that statins may decrease the risk of cancers. However, available evidence on prostate cancer (PCa) is conflicting.
Dipika Bansal +4 more
core +4 more sources
Frontiers in Oncology, 2021 Triple-negative breast cancer (TNBC) is more aggressive and has poorer prognosis compared to other subtypes of breast cancer. Epithelial-to-mesenchymal transition (EMT) is a process in which epithelial cells transform into mesenchymal-like cells capable ...
Chanjuan Zheng +26 more
doaj +1 more source
Characterization of the human omega-oxidation pathway for omega-hydroxy-very-long-chain fatty acids [PDF]
, 2008 Very-long-chain fatty acids (VLCFAs) have long been known to be degraded exclusively in peroxisomes via beta-oxidation. A defect in peroxisomal beta-oxidation results in elevated levels of VLCFAs and is associated with the most frequent inherited ...
Dacremont, Georges +4 more
core +2 more sources