Results 31 to 40 of about 15,201 (138)

Bioactive Natural Products in Cardiovascular Disease: Focus on Thrombotic Events

open access: yesPhytotherapy Research, EarlyView.
An overview of the role of natural products (NP) in cardiovascular disease prevention, highlighting key mechanisms of action: including antiplatelet, antithrombotic, anti‐inflammatory, and antioxidant effects. Additionally, it illustrates the integration of diet–drug interactions, nutritional epigenetics, and the role of artificial intelligence in ...
Maria Nektaria Magkoulia   +1 more
wiley   +1 more source

Precisely Engineering Biomimetic Nanoparticles via Controlled Cell Membrane Coating

open access: yesSmall, EarlyView.
Precise engineering of cell membrane‐coated nanoparticles (CMNPs) requires coordinated control over particle size, coating integrity, and membrane leaflet orientation. This review integrates key synthesis parameters, assembly strategies, and analytical methods that govern these features, revealing how structural control underpins biomimetic function ...
Jie Lay Lim   +4 more
wiley   +1 more source

In vivo and in vitro anti-inflammatory and anti-nociceptive activities of lovastatin in rodents

open access: yesBrazilian Journal of Medical and Biological Research, 2011
Statins are among the most prescribed drugs in recent clinical practice. They are also known for their pleiotropic actions, which are independent of their lipid-lowering properties.
D.O. Gonçalves   +7 more
doaj   +3 more sources

IMMOBILIZATION AND APPLICATION OF PARTIAL PURIFIED LOVASTATIN PRODUCED FROM LOCAL ISOLATE ASPERGILLUS TERREUS A50 USING SOLID STATE FERMENTATION

open access: yesThe Iraqi Journal of Agricultural science, 2021
This work was designed to study the free and immobilized partial purified lovastatin in various applications. The results of HMG-CoA reductase inhibition showed enzyme inhibition at 10 mM of standard and partial purified lovastatin with specific activity
A. J. R. Al-Sa'ady, G. M. Aziz
doaj   +1 more source

Is Hypercortisolism Treatable? Which Patients Should Be Treated and How—A Practical Guide for Clinicians

open access: yesDiabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aim To provide a practical guide on when to suspect endogenous hypercortisolism, how to use the overnight 1‐mg dexamethasone suppression test (DST) for targeted case‐finding, and which patients are most likely to benefit from treatment.
Juan Pablo Frias
wiley   +1 more source

Structure of AI Responses With Complex Patient Analysis for Patient Alternatives and Patient Modifiers

open access: yesEuropean Journal of Dental Education, EarlyView.
ABSTRACT Background Artificial intelligence (AI) is already a powerful tool that is rapidly growing within the dental sector. Reports of structure and characteristics of AI responses to patient scenarios are limited. Purpose To analyse characteristics and structure of AI responses to prompts for treatment planning alternatives and patient alternatives ...
David C Johnsen   +4 more
wiley   +1 more source

Mystery and misery of locally‐delivered drug therapy in periodontics. Historical concepts and current state

open access: yesPeriodontology 2000, EarlyView.
Abstract The primary objective is to critically analyze approaches to local therapy for periodontal disease, particularly in light of its well‐established systemic implications. We specifically address common misconceptions and overestimations regarding the potential of local treatments in contrast to their actual clinical effectiveness.
Andrea Mombelli, Alkisti Zekeridou
wiley   +1 more source

Lovastatin Decreases the Expression of CD133 and Influences the Differentiation Potential of Human Embryonic Stem Cells

open access: yesStem Cells International, 2016
The lipophilic statin lovastatin decreases cholesterol synthesis and is a safe and effective treatment for the prevention of cardiovascular diseases. Growing evidence points at antitumor potential of lovastatin.
Ade Kallas-Kivi   +2 more
doaj   +1 more source

Antibiotic‐mediated immune modulation in periodontitis

open access: yesPeriodontology 2000, EarlyView.
Abstract Periodontitis is a chronic inflammatory disease affecting the supporting structures of the teeth. Although initiated by dysbiotic microbial communities, its progression is largely driven by the host's uncontrolled inflammatory response. While antibiotics have conventionally been employed in periodontitis therapy for their antimicrobial ...
Lina J. Suárez   +6 more
wiley   +1 more source

Lovastatin Alleviates Endothelial-to-Mesenchymal Transition in Glomeruli via Suppression of Oxidative Stress and TGF-β1 Signaling

open access: yesFrontiers in Pharmacology, 2017
Statins may decrease chronic kidney diseases (CKDs) risk, but their underlying molecular mechanisms are not completely understood. Recent studies indicate Endothelial-to-mesenchymal transition (EndMT) plays an important role contributing to renal ...
Zejun Ma   +6 more
doaj   +1 more source

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