Results 21 to 30 of about 15,201 (138)

Lovastatin Production by Aspergillus sclerotiorum Using Agricultural Waste

Food Technology and Biotechnology, 2020
Research background. Lovastatin is a well-known drug used to reduce hypercholesterolaemia. However, the cost of lovastatin production is still high.
Jutarut Iewkittayakorn, Kannika Kuechoo, Yaowapa Sukpondma, Vatcharin Rukachaisirikul, Souwalak Phongpaichit, Wilaiwan Chotigeat   +5 more
doaj   +1 more source

New insight into occurrence, quantification and bioactivities of lovastatin from natural resources (mushroom, red yeast rice and tea)

Journal of Agriculture and Food Research
Lovastatin is a naturally occurring secondary metabolite. It has garnered significant attention due to its potent cholesterol-lowering property, mainly achieved through the inhibition of HMG-CoA reductase. This review explores the multifaceted aspects of
Chapa Ramasinghe, Baojun Xu
doaj   +1 more source

Effects of lovastatin therapy on guinea pig low density lipoprotein composition and metabolism.

Journal of Lipid Research, 1989
Lovastatin therapy is known to induce hepatic low density lipoprotein (LDL) receptor mRNA and LDL receptor activity. Yet, in studies in humans and animals it has been difficult to demonstrate an enhancement of the plasma fractional catabolic rate (FCR ...
L Berglund, M F Sharkey, R L Elam, J L Witztum   +3 more
doaj   +1 more source

Oxamniquine, praziquantel and lovastatin association in the experimental Schistosomiasis mansoni

Memorias do Instituto Oswaldo Cruz, 2008
The activity of lovastatin associated with oxamniquine or praziquantel against schistosomiasis mansoni was evaluated in mice infected with Schistosoma mansoni.
Neusa Araújo, Ana Carolina Alves de Mattos, Ana Karine Sarvel, Paulo Marcos Zech Coelho, Naftale Katz   +4 more
doaj   +1 more source

Comparison of Transforming Growth Factor-Beta1 and Lovastatin on Differentiating Mesenchymal Stem Cells toward Nucleus Pulposus-like Phenotype: An Cell Culture Study [PDF]

Asian Spine Journal, 2019
Study Design In Vitro cell culture study. Purpose This study aims to investigate the impact of transforming growth factor-beta1 (TGF-β1) and lovastatin on differentiating human mesenchymal stem cells (MSCs) toward nucleus pulposus (NP)-like phenotype ...
Shu-Hua Yang, Kai-Chiang Yang, Chih-Wei Chen, Ting-Chun Huang, Yuan-Hui Sun, Ming-Hsiao Hu   +5 more
doaj   +1 more source

Lovastatin Inhibits EMT and Metastasis of Triple-Negative Breast Cancer Stem Cells Through Dysregulation of Cytoskeleton-Associated Proteins

Frontiers in Oncology, 2021
Triple-negative breast cancer (TNBC) is more aggressive and has poorer prognosis compared to other subtypes of breast cancer. Epithelial-to-mesenchymal transition (EMT) is a process in which epithelial cells transform into mesenchymal-like cells capable ...
Chanjuan Zheng, Chanjuan Zheng, Chanjuan Zheng, Shichao Yan, Shichao Yan, Lu Lu, Lu Lu, Hui Yao, Hui Yao, Guangchun He, Guangchun He, Sisi Chen, Sisi Chen, Ying Li, Ying Li, Xiaojun Peng, Zhongyi Cheng, Mi Wu, Mi Wu, Qiuting Zhang, Qiuting Zhang, Guifei Li, Guifei Li, Shujun Fu, Shujun Fu, Xiyun Deng, Xiyun Deng   +26 more
doaj   +1 more source

The Anti-Methanogenic Activity of Lovastatin in Batch Cultures Using Rumen Inoculum from Sheep, Goats, and Cows

Fermentation
Enteric methanogenesis in ruminants is identified as one of the primary anthropogenic sources of total atmospheric methane. Recent evidence suggests that rumen methanogenesis is significantly suppressed by lovastatin.
Amaury Ábrego-García, Gustavo Gerardo Medina-Mendoza, Luis Alberto Miranda-Romero   +2 more
doaj   +1 more source

Transgelin 2 participates in lovastatin-induced anti-angiogenic effects in endothelial cells through a phosphorylated myosin light chain-related mechanism. [PDF]

PLoS ONE, 2012
BACKGROUND: Anti-angiogenic activity is considered to play a key role in the statin-induced anti-tumor effects. We aimed to identify new targets underlying this pleiotropic effect of lovastatin.
Yuan Xiao, Yuhua Li, Jing Han, Yan Pan, Lu Tie, Xuejun Li   +5 more
doaj   +1 more source

Utilisation of vegetable oils in the production of lovastatin by Aspergillus terreus ATCC 20542 in submerged cultivation [PDF]

Maejo International Journal of Science and Technology, 2011
The effect of vegetable oils as a supplementary carbon source during the production of lovastatin by Aspergillus terreus ATCC 20542 in submerged culture was investigated.
Pattana Sripalakit
doaj  

Characterization of Lysosomal Hydrolases and Transporters and Their Age‐Dependent Variability: Relevance to Drug Metabolism and Transport of Small Molecule and Biologic Drugs

Clinical Pharmacology &Therapeutics, EarlyView.
Lysosomes play a key role in the accumulation, catabolism, and transport of endogenous and exogenous metabolites and proteins and are involved in drug metabolism and prodrug activation. However, the protein abundance and interindividual variability of lysosomal drug‐metabolizing enzymes and transporters (DMETs) remain underexplored.
Darshak Gadara, Dilip Kumar Singh, Sandhya Subash, Guihua Yue, Deepak Ahire, Chris Bohl, Maciej Czerwinski, Stephanie Helmstetter, Scott Heyward, Robert S. Jones, Cyrus Khojasteh, Ryota Kikuchi, Priyanka Kulkarni, Bin Ma, Bernard Murray, Chris Seib, Bill Smith, David M. Stresser, Mitchell E. Taub, Ting Wang, Bhagwat Prasad   +20 more
wiley   +1 more source