Results 51 to 60 of about 17,598 (157)

Anti-tumor effect of lovastatin on glioblastoma animal model and induction of DR5 expression by peri-tumoral administration of lovastatin in nude mice.

open access: yes, 2017
(A) The U87 MG cells were treated with different concentrations of lovastatin for 48 hours, and then cell cycle progression was analyzed by PI staining.
Wai Sang Poon (397929)   +8 more
core   +1 more source

Effects of lovastatin on the pharmacokinetics of diltiazem and its main metabolite, desacetyldiltiazem, in rats: possible role of cytochrome P450 3A4 and P-glycoprotein inhibition by lovastatin

open access: yes, 2010
Objectives The purpose of this study was to examine the effects of lovastatin on cytochrome P450 (CYP) 3A4 and P-glycoprotein (P-gp) in vitro and then to determine the effects of lovastatin on the pharmacokinetics of diltiazem and its ...
Joong-Wha Chung   +7 more
core   +1 more source

Integrated Continuous Process Design for Crystallisation, Spherical Agglomeration, and Filtration of Lovastatin [PDF]

open access: yes
Purpose: This work seeks to improve the particle processability of needle-like lovastatin crystals and develop a small-footprint continuous MicroFactory for its production.
Islam, Muhammad T   +21 more
core   +4 more sources

Electrospinning of polymer nanofibers with lovastatin

open access: yes, 2020
Majhna vodotopnost in hitrost raztapljanja zdravilnih učinkovin sta dandanes velika izziva pri razvoju formulacije, saj je veliko novih učinkovin težko vodotopnih.
Dolinšek, Bojan
core  

ENHANCED ORAL BIOAVAILABILITY IN ALBINO RABBITS OF LOVASTATIN NANOPARTICLES

open access: yes, 2014
The aim of the study was to compare the single dose oral bioavailability of lovastatin (LV) nanoparticles in albino rabbits. Plasma was analyzed for lovastatin using a sensitive, reproducible, accurate and validated RP-HPLC method.
Shinde, Anilkumar Jalindar
core   +1 more source

Lovastatin enhances the efficacy of TRAIL on subcutaneous brain tumor in mice models.

open access: yes, 2017
The nude mice bearing subcutaneous brain tumor were randomly divided into control group, lovastatin group (5 mg/Kg • day lovastatin), and lovastatin plus TRAIL group (5 mg/Kg • day lovastatin plus 200 ng TRAIL).
Wai Sang Poon (397929)   +8 more
core   +1 more source

Novel approaches to improve lovastatin production in membrane gradostat bioreactor

open access: yes
International audienceLovastatin is a blood cholesterol reduction medicine and can be produced as a fungal secondary metabolite. Although the industrial production of lovastatin is generally achieved by Aspergillus terreus fungus in submerged culture, it
Mohseny Takloo, Sepide   +4 more
core   +1 more source

A REVIEW: LOVASTATIN PRODUCTION AND APPLICATIONS

open access: yes, 2013
Cholesterol is an organic compound, which is produced in humans by a complex metabolism. It acts as a precursor for the synthesis of many steroids, vitamin D and also helps in membrane transport.
K V, Radha, D, Lakshmanan
core  

Endophytic Fungi: A Poor Candidate for the Production of Lovastatin [PDF]

open access: yes, 2014
Aim: The aim of the present study was to screen soil and endophytic fungi for production oflovastatin.Methodology: Soil fungi were isolated by dilution plating technique and endophytic fungi from selected medicinal plants by using standard procedures ...
Savitha, J.   +2 more
core  

Content and Uniformity of Mexican Manufactured Lovastatin and Warfarin Versus American Manufactured Lovastatin and Warfarin

open access: yes, 2005
Class of 2005 AbstractObjective: To analyze the quantity of active ingredient as well as the content uniformity of lovastatin and warfarin manufactured in Mexico as compared to the lovastatin and warfarin manufactured in the United States.
Choiniere, Jennifer
core  

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