Results 71 to 80 of about 31,024 (202)

Post-ischaemic immunological response in the brain: targeting microglia in ischaemic stroke therapy [PDF]

, 2020
Microglia, the major endogenous immune cells of the central nervous system, mediate critical degenerative and regenerative responses in ischaemic stroke.
Chen, Ruoli, Dallas, Mark L., Jenkins, Stuart, Rawlinson, Charlotte, Thei, Laura   +4 more
core   +3 more sources

The Burden of Adverse Drug Reactions in Africa in the Context of Pharmacogenetics‐Based Clinical Guidelines

Clinical Pharmacology &Therapeutics, Volume 119, Issue 5, Page 1382-1390, May 2026.
Genetic variation has a significant impact on patients' response to medicines. Variations in important pharmacogenes have been evaluated in several studies and consequently led to international guidelines from clinical pharmacogenomics consortia. However, there are limited examples of these being implemented across the African continent despite the ...
Janine Scholefield, Tinashe A. Mazhindu, Mohamed Nagy, David Twesigomwe, Gaye Agesa, Collen Masimirembwa   +5 more
wiley   +1 more source

COMPARATIVE EFFECTS OF LOVASTATIN AND SIMVASTATIN ON LIVER FUNCTION TESTS IN HYPERLIPIDAEMIC PATIENTS [PDF]

The Medical Journal of Basrah University, 2007
Objective: to evaluate the effect of lovastatin and simvastatin on liver function tests in a number of hyperlipidaemic patients. Design: case control study.
Zena Sattam Hamad Al-Jubori, Isam Hamo Mahmood   +1 more
doaj   +1 more source

Equipped for success: genomes and metabolomes of the European Amanita muscaria are conserved in its novel South African range

New Phytologist, Volume 250, Issue 3, Page 1863-1883, May 2026.
Summary Plants and soils have been moved around the world for centuries, but invasive mushrooms receive scant attention. The Amanita muscaria species complex was introduced to South Africa in the context of forestry, but its origins, ecology and recent evolution are unstudied. We sequenced the genomes of 24 Northern and Southern Hemisphere A. muscaria,
Grant R. Nickles, Cecelia K. Stokes, Deborah L. Narh, Kira M. T. Lynn, Savannah R. Fuqua, Corbin Bryan, Brooke M. Allen, Christopher P. Bivins, Jin Woo Bok, J. Stephen Brewer, Sikelela T. Buthelezi, Jahiya P. R. M. Clark, Kerri L. Coon, Lauren R. Corby, Martin P. A. Coetzee, Claudette Dewing, Tuan A. Duong, Mathew A. Harris, Nancy P. Keller, Katlego Kopotsa, Frances A. Lane, Holly L. Nichols, Alandie Nieuwoudt, Martin A. Nuñez, Miguel E. Medina Munoz, Sung Chul Park, Nam Q. Pham, Kaetlyn T. Ryan, Myriam Solís, Rytas Vilgalys, Jasmine Marea Wallace, Yen‐Wen Wang, Brenda D. Wingfield, Michael J. Wingfield, Travis K. Worley, Taylor A. Zallek, Mostafa Zamanian, Jason D. Hoeksema, Milton T. Drott, Anne Pringle   +39 more
wiley   +1 more source

Development of One Pot Strategy for Hyper Production and In Vivo Evaluation of Lovastatin

Molecules, 2020
The aim of this project was to improve the Aspergillus terreus strain and pretreatment of sugarcane bagasse as carrier substrate for bulk production of lovastatin, a cholesterol-lowering drug, in solid state fermentation.
Muhammad Azeem, Muhammad Arshad, Saqib Mahmood, Shazia Abrar, Ameer Fawad Zahoor, Sadia Javed, Bisma Tariq, Khizar Hayyat   +7 more
doaj   +1 more source

Ampelopsis Grossedentata Flavonoids Alleviate Hepatic Damage Through Remodeling Intestinal Microflora and Reducing Oxidative Stress in Rats

Food Science &Nutrition, Volume 14, Issue 4, April 2026.
This graphical abstract illustrates the multi‐target antioxidant and anti‐inflammatory effects of AGF in alleviating liver injury, and their association with gut microbiota modulation and enrichment of beneficial microbes. ABSTRACT To investigate the antioxidant effects and underlying mechanisms of Ampelopsis grossedentata flavonoids (AGF) in rats fed ...
Hao Shi, Bo Zhou, Jing Wang, Li Lan Lei
wiley   +1 more source

The Effects and Mechanisms of Pomegranate on Regulating Lipid Metabolism

Food Science &Nutrition, Volume 14, Issue 4, April 2026.
This study established a high‐fat diet‐induced hyperlipidemia rat model to investigate the lipid‐lowering effects of pomegranate. Pomegranate intervention significantly reduced serum total cholesterol (TC), triglyceride (TG), and low‐density lipoprotein cholesterol (LDL‐C) levels, while alleviating hepatic steatosis by decreasing liver weight and fat ...
Hao Wang, Jingtao Liu, Xin Dong, Tiantian Shi, Xuena Zhang, Yide He, Shaonan Hu, Yuewu Wang, Jian Zheng, Peifeng Xue   +9 more
wiley   +1 more source

Screening and genetic engineering of marine-derived Aspergillus terreus for high-efficient production of lovastatin

Microbial Cell Factories
Background Lovastatin has widespread applications thanks to its multiple pharmacological effects. Fermentation by filamentous fungi represents the major way of lovastatin production.
Han Na, Yao-yao Zheng, Yaoning Jia, Jingzhao Feng, Jizi Huang, Jihao Huang, Chang-Yun Wang, Guangshan Yao   +7 more
doaj   +1 more source

Thalidomide, dexamethasone and lovastatin with autologous stem cell transplantation as a salvage immunomodulatory therapy in patients with relapsed and refractory multiple myeloma [PDF]

, 2011
The treatment of patients with multiple myeloma usually includes many drugs including thalidomide, lenalidomide and bortezomib. Lovastatin and other inhibitors of HMG-CoA reductase demonstrated to exhibit antineoplasmatic and proapoptotic properties in ...
Marek Hus, Norbert Grzasko, Marta Szostek, Andrzej Pluta, Grzegorz Helbig, Dariusz Woszczyk, Maria Adamczyk-Cioch, Dariusz Jawniak, Wojciech Legiec, Marta Morawska, Justyna Kozinska, Piotr Waciński, Anna Dmoszynska   +12 more
core   +1 more source

Scalable assay to identify inhibitors of prion‐like propagation of protein misfolding as potential therapeutics for neurodegeneration

Protein Science, Volume 35, Issue 4, April 2026.
Abstract Protein misfolding is linked to many neurodegenerative diseases. In some cases, misfolding can propagate through a prion‐like mechanism whereby natively folded molecules are converted into more copies of the misfolded isoform. Prion‐like propagation of misfolding is an attractive therapeutic target, but difficulties with assaying conversion ...
Abhishek Narayan, Krishna Neupane, Michael T. Woodside   +2 more
wiley   +1 more source