Results 61 to 70 of about 15,201 (138)

Production of Lovastatin by Wild Strains of

Natural Product Communications, 2011
A wild fungal strain of Aspergillus terreus , labeled as PM3, was isolated by using the Candida albicans bioassay and confirmed by 18S r DNA analyses. Lovastatin was produced by submerged and solid state fermentations.
Ravindra H. Patil, Prakash Krishnan, Vijay L. Maheshwari   +2 more
doaj   +1 more source

Effects of lovastatin on biliary lipid secretion and bile acid metabolism in humans.

Journal of Lipid Research, 1991
Lovastatin, an inhibitor of HMG-CoA reductase, lowers cholesterol saturation of bile. To determine the mechanism of this effect and further define the role of cholesterol synthesis in regulation of biliary lipid metabolism, we studied ten human ...
JC Mitchell, GM Logan, BG Stone, WC Duane   +3 more
doaj   +1 more source

Altered apolipoprotein B metabolism in very low density lipoprotein from lovastatin-treated guinea pigs.

Journal of Lipid Research, 1994
Previous studies have shown that treatment of guinea pigs with lovastatin alters the composition and the metabolic properties of circulating low density lipoprotein (LDL).
L F Berglund, W F Beltz, R L Elam, J L Witztum   +3 more
doaj   +1 more source

Supercritical Fluid Extraction of Lovastatin from the Wheat Bran Obtained after Solid-State Fermentation

Food Technology and Biotechnology, 2009
The objective of the present work is to extract lovastatin with minimum impurity by using supercritical carbon dioxide (SC-CO2). A strain of Aspergillus terreus UV 1617 was used to produce lovastatin by solid-state fermentation (SSF) on wheat bran as a ...
Ruchir C. Pansuriya, Rekha S. Singhal
doaj  

The Role of Quorum Sensing in Enhancing Lovastatin and Pigment Production in Monascus purpureus C322

Fermentation
Monascus purpureus is a filamentous fungus known for producing pharmaceutically valuable secondary metabolites, including azaphilone pigments and lovastatin.
Sirisha Yerramalli, Stephen J. Getting, Godfrey Kyazze, Tajalli Keshavarz   +3 more
doaj   +1 more source

Lovastatin Reduces Stemness via Epigenetic Reprograming of BMP2 and GATA2 in Human Endometrium and Endometriosis

Cell Journal, 2017
Objective The stem cell theory in the endometriosis provides an advanced avenue of targeting these cells as a novel therapy to eliminate endometriosis.
Mehrdad Noruzinia, Mahdieh Taghizadeh
doaj  

Anti-proliferative and apoptotic effects of Lovastatin on K562 Erthromyloidy cancer cell line

مجله دانشگاه علوم پزشکی گرگان, 2017
Background and Objective: Lovastatin is a HMG-CoA reductase inhibitor and used for the treatment of hypercholesterolemia. Inhibition of HMG-CoA reductase results in inhibiting the activity of the Ras proto-oncogene that has mutations in most cancers ...
M Vaezi, M Mohammadzadeh, Y Pazhang
doaj  

Effect of Lovastatin on Learning and Spatial Memory in Adult Male Rats

Iranian South Medical Journal, 2018
Background: Previous studies have shown that statins exert neuroprotective effects. The aim of the present study was to evaluate the effects of lovastatin on learning and memory processes in adult male rats without brain damage. Materials and Methods: In
Azadeh Eskandary, Ahmad Ali Moazedi, Nastaran Zamani   +2 more
doaj  

Lovastatin Targets LIPA to Induce ER Stress-Mediated Apoptosis in Acute Myeloid Leukemia: A Multi-Omics Study. [PDF]

Int J Gen Med
Wei J, Nai GY, Lin G, Huang YM, Zhou WJ, Liu RR.   +5 more
europepmc   +1 more source

The RNAi machinery regulates lovastatin biosynthesis via microRNA-like RNAs in industrial <i>Aspergillus terreus</i>. [PDF]

Synth Syst Biotechnol
Gu M, Feng D, Liu Y, Zhang W, Zhou Y, Zhang X, Du S, Huang X, Lu X.   +8 more
europepmc   +1 more source