Results 81 to 90 of about 31,024 (202)

A Novel Mutation in the Upstream Open Reading Frame of the CDKN1B Gene Causes a MEN4 Phenotype [PDF]

, 2013
PubMed ID: 23555276This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
A Borriello, A Falchetti, A Mehta, A Ozawa, A Wiestner, A Yoon, Alessandro Quattrone, BG Luukkonen, C Le Sage, Carla Scaroni, CC Spevak, CJ Sherr, CJ Sherr, D Malanga, Daniela Regazzo, Denis Ciato, DR Morris, Elena Pardi, Filomena Cetani, Francesca Boaretto, Franco Mantero, G Beffagna, G Johannes, G Occhi, GC Scheper, Giampaolo Trivellin, Gianluca Occhi, Giuseppe Opocher, IM Chu, J Costa-Guda, J Slingerland, K Wethmar, L Liu, L Quintanilla-Martinez, M Georgitsi, M Kozak, M Kozak, M Kullmann, M Matsui, Marshall S. Horwitz, MD Larrea, ML Crowe, ML Fero, Márta Korbonits, Natalia S. Pellegata, NS Pellegata, P Chomczynski, RV Thakker, S Igreja, S Molatore, S Ye, Sara Bobisse, SE Calvo, Sergio Ferasin, SI Reed, SK Agarwal, U Göpfert, Viktoryia Sidarovich, W Zhou, WK Miskimins, Y Wen   +60 more
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The Crosstalk Mechanisms Between Ferroptosis and Pyroptosis and Their Applications in Diseases: From Molecular Networks to Clinical Strategies

Journal of Cellular and Molecular Medicine, Volume 30, Issue 8, April 2026.
ABSTRACT Ferroptosis and pyroptosis are two distinct forms of regulated cell death that play crucial roles in cancer, neurodegeneration, and inflammatory diseases. Ferroptosis is characterised by iron‐dependent lipid peroxidation, while pyroptosis is an inflammatory cell death mediated by gasdermin proteins.
Wei‐Yi Zhao, Lu‐yao Li, Fang‐wang Ye, Jin‐Wei Zhao   +3 more
wiley   +1 more source

Controlled release of lovastatin from poly(lactic-co-glycolic acid) nanoparticles for direct pulp capping in rat teeth

International Journal of Nanomedicine, 2017
Hung-Pin Lin,1,2,* Han-Ping Tu,3,* Yu-Ping Hsieh,4 Bor-Shiunn Lee3 1Department of Dentistry, MacKay Memorial Hospital, 2Department of Dentistry, School of Dentistry, National Taiwan University, 3Graduate Institute of Oral Biology, School of Dentistry ...
Lin HP, Tu HP, Hsieh YP, Lee BS
doaj  

Structure‐Guided Engineering of a Promiscuous O‐Methyltransferase for a SAM Regeneration Biocatalysis Platform of Methylated Pharmaceuticals

Advanced Science, Volume 13, Issue 13, 3 March 2026.
A substrate promiscuous and regioselective O‐methyltransferase, SmOMT, is functionally and structurally characterized. A double mutant, SmOMTE152A/I306A, exhibited enhanced catalytic activity. By coupling this mutant with a mutant halide methyltransferase, AtHMTV140T, for SAM regeneration, a superior artificial fusion enzyme, AtHMTV140T‐L95‐SmOMTE152A ...
Xiran Xiong, Jun Song, Shihan Li, Lu Jin, Qi He, Baohui Zhang, Yan Cao, Shanyong Yi, Yanfang Yang, Xiang Li, Juan Li, Wei Huang   +11 more
wiley   +1 more source

Effects of lovastatin on biliary lipid secretion and bile acid metabolism in humans.

Journal of Lipid Research, 1991
Lovastatin, an inhibitor of HMG-CoA reductase, lowers cholesterol saturation of bile. To determine the mechanism of this effect and further define the role of cholesterol synthesis in regulation of biliary lipid metabolism, we studied ten human ...
JC Mitchell, GM Logan, BG Stone, WC Duane   +3 more
doaj   +1 more source

The Influence of Physical Parameters Towards Hyper Cholesterol Reducing Agent Production, Lovastatin, Under Solid Substrate Fermentation (SSF) Condition [PDF]

, 2012
Two potential substrates namely rice bran and unprocessed brown rice indicated positive result of lovastatin existence. Aspergillus Niger SAR I, our local isolated fungus, took a responsibility to cooperate with those substrates in SSF system.
Aryantha, I. N. (I), Ibrahim, D. (Darah), Rashid, S. A. (Syarifah)   +2 more
core   +1 more source

Mechanism and treatment for learning and memory deficits in mouse models of Noonan syndrome. [PDF]

, 2014
In Noonan syndrome (NS) 30-50% of subjects show cognitive deficits of unknown etiology and with no known treatment. Here, we report that knock-in mice expressing either of two NS-associated mutations in Ptpn11, which encodes the nonreceptor protein ...
Araki, Toshiyuki, Balaji, J, Burger, Corinna, Butz, Delana, Cai, Ying, Ehninger, Dan, Kaang, Bong-Kiun, Kang, Minkyung, Kim, Hyong Kyu, Kwak, Chuljung, Lee, Yong-Seok, Nam, Christine I, Neel, Benjamin G, Oh, Jun-Young, Ryu, Hyun-Hee, Sano, Yoshitake, Silva, Alcino J, Zhou, Miou   +17 more
core   +2 more sources

Production of Lovastatin by Wild Strains of

Natural Product Communications, 2011
A wild fungal strain of Aspergillus terreus , labeled as PM3, was isolated by using the Candida albicans bioassay and confirmed by 18S r DNA analyses. Lovastatin was produced by submerged and solid state fermentations.
Ravindra H. Patil, Prakash Krishnan, Vijay L. Maheshwari   +2 more
doaj   +1 more source

Optimization of Culture Conditions for Maximal Lovastatin Production by Aspergillus terreus (KM017963) under Solid State Fermentation

Hayati Journal of Biosciences, 2015
Effects of various culture conditions on lovastatin production were investigated in Aspergillus terreus (KM017963) grown under solid state fermentation with wheat bran.
Praveen Vadakke Kamath, Bhargavi Santebennur Dwarakanath, Avinash Chaudhary, Savitha Janakiraman   +3 more
doaj   +1 more source

The impact of generic reference pricing interventions in the statin market [PDF]

The objective of this study was to evaluate the intended and unintended impact on pharmaceutical use and sales of three public financing reforms applied to the prescription of statins: a Spanish generic reference pricing (RP) system for lovastatin and ...
Jaume Puig
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