Results 151 to 160 of about 6,856 (183)
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1988
A non-interferon lymphokine elaborated from PHA and Con A-stimulated human T-cell hybridoma, T-CEMA, has been found to activate monocyte-derived macrophages for the intracellular killing of L. donovani (antileishmanial MAF). This T-cell hybridoma derived antileishmanial MAF which has an apparent mw of 65,000 and pI of 5.3-5.6, contains neither ...
A, Van Niel +4 more
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A non-interferon lymphokine elaborated from PHA and Con A-stimulated human T-cell hybridoma, T-CEMA, has been found to activate monocyte-derived macrophages for the intracellular killing of L. donovani (antileishmanial MAF). This T-cell hybridoma derived antileishmanial MAF which has an apparent mw of 65,000 and pI of 5.3-5.6, contains neither ...
A, Van Niel +4 more
openaire +2 more sources
Antileishmanial Physalins fromPhysalis minima
Chemistry & Biodiversity, 2005Three new physalins (1-3) and a new withanolide 7 have been isolated from the whole plant of Physalis minima, along with three known physalins: physalin H (4), isophysalin B (5), and 5beta,6beta-epoxyphysalin B (6). Their structures were deduced on the basis of in-depth spectroscopic analyses.
M. Iqbal Choudhary +5 more
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Antimony Oxidation States in Antileishmanial Drugs
The American Journal of Tropical Medicine and Hygiene, 1995Chemical methods specific for the determination of the levels of trivalent antimony (Sb+3) and pentavalent antimony (Sb+5) were used to investigate proprietary formulas used to treat leishmaniasis. Trivalent antimony was determined by differential pulse polarography, whereas Sb+5 was determined by iodine titration.
M A, Franco +3 more
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Antileishmanial activity and cytotoxicity of Brazilian plants
Experimental Parasitology, 2014Leishmaniasis is a major public health problem, and the alarming spread of parasite resistance has increased the importance of discovering new therapeutic products. The present study aimed to investigate the in vitro leishmanicidal activity from 16 different Brazilian medicinal plants. Stationary-phase promastigotes of Leishmania amazonensis and murine
Tatiana G, Ribeiro +12 more
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Targeting sterol metabolism for the development of antileishmanials
Trends in Parasitology, 2015Membrane sterol profiles differ between humans and Leishmania parasites, and the sterol pathway has been investigated for potential therapeutic targets. Recently, mutants of the C14α-sterol demethylase in Leishmania major were found to have several major alterations such as increased membrane fluidity, hypersensitivity to heat stress, and severe ...
Pomel, Sébastien +2 more
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Manzamine alkaloids as antileishmanial agents: A review
European Journal of Medicinal Chemistry, 2015Leishmaniasis is considered as one of the most Neglected Tropical Diseases (NTDs) in the world, caused by protozoan parasites of the genus Leishmania. Leishmaniasis control profoundly depends upon chemotherapy which includes pentavalent antimonials, paromomycin, pentamidine, amphotericin B and miltefosine. Miltefosine is the only oral drug used for the
Penta, Ashok +2 more
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Antileishmanial activity of nanocurcumin.
Therapeutic delivery, 2012Leishmaniasis is an endemic disease having a wide spectrum ranging from visceral, cutaneous and mucocutaneous forms caused by unicellular, obligate intracellular parasites of the monocyte-macrophage system. The aim of the present study was to develop an effective, nontoxic and biodegradable polymeric drug-delivery system encapsulating curcumin in its ...
Mohd, Samim +4 more
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Antileishmanial action of endoperoxides
2021Bachelorarbeit - Veterinärmedizinische Universität Wien ...
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A review of natural products with antileishmanial activity
Phytomedicine, 2005J M Barbosa-Filho
exaly