Results 151 to 160 of about 4,370 (170)

Antileishmanial Agents. Part 4. Synthesis and Antileishmanial Activity of Novel Terpenyl Pyrimidines.

ChemInform, 2005
AbstractFor Abstract see ChemInform Abstract in Full Text.
Naveen Chandra, Ramesh Ramesh, Ashutosh Ashutosh, Neena Goyal, S. N. Suryawanshi, Suman Gupta   +5 more
openaire   +1 more source

Aryloxy cyclohexyl imidazoles: A novel class of antileishmanial agents

Bioorganic & Medicinal Chemistry Letters, 2009
Thirteen novel aryloxy cyclohexane-based mono and bis imidazoles were synthesized and evaluated in vitro as antileishmanials against Leishmania donovani and cytotoxicity assessed. These compounds were better than the existing drugs, sodium stibogluconate and pentamidine in respect to IC(50) and SI values. Promising compounds were tested further in vivo.
Nagarapu, Srinivas, Shraddha, Palne, , Nishi, Suman, Gupta, Kalpana, Bhandari   +4 more
openaire   +2 more sources

Repurposing Glyburide as Antileishmanial Agent to Fight Against Leishmaniasis

Protein & Peptide Letters, 2019
Background:Leishmaniasis is caused by a protozoan parasite, Leishmania. It is common in more than 98 countries throughout the world. Due to insufficient availability of antileishmanial chemotherapeutics, it is an urgent need to search for new molecules which have better efficacy, low toxicity and are available at low cost.Objectives:There is a high ...
Abdur, Rub, Kamal, Shaker, Mohammad, Kashif, Mohd, Arish, Abdul Aziz Bin, Dukhyil, Bader Mohammed, Alshehri, Mohammed A, Alaidarous, Saeed, Banawas, Khwaja, Amir   +8 more
openaire   +2 more sources

Synthesis and biological evaluation of trifluralin analogues as antileishmanial agents

Bioorganic & Medicinal Chemistry, 2010
A series of new analogues of trifluralin (TFL) were synthesized and characterized in view of changing the unfavorable properties that limits its use as antileishmanial agent. Some of the TFL analogues display more activity than a standard drug (miltefosine) against the promastigote forms of Leishmania infantum and Leishmania donovani and the ...
M A, Esteves, I, Fragiadaki, R, Lopes, E, Scoulica, M E M, Cruz   +4 more
openaire   +2 more sources

Identification of dehydroxy isoquine and isotebuquine as promising antileishmanial agents

Archiv der Pharmazie, 2019
AbstractTraditional antimalarial drugs based on 4‐aminoquinolines have exhibited good antiproliferative activities against Leishmania parasites; however, their clinical use is currently limited. To identify new 4‐aminoquinolines to combat American cutaneous leishmaniasis, we carried out a full in vitro evaluation of a series of dehydroxy isoquines and ...
Angel H. Romero, Noris Rodríguez, Simón E. López, Henry Oviedo   +3 more
openaire   +2 more sources

The Future for Antileishmanial Chemotherapeutic Agents: A Review

1989
The utility of antileishmanial agents will probably vary with the form of leishmaniasisns being treated. One way to categorize the cutaneous leishmaniases is to divide them into L. tropica and L. mexicana complexes on the one hand, and L. braziliensis complex on the other hand (Table 1) Except in rare cases, cutaneous leishmaniasis due to L.
openaire   +1 more source

Diamidines as antitrypanosomal, antileishmanial and antimalarial agents.

Current opinion in investigational drugs (London, England : 2000), 2006
Diamidine-containing compounds have a long history of use in the treatment of African trypanosomiasis and leishmaniasis. The discovery that diamidine prodrugs possess in vivo antimicrobial activity when administered orally has led to a renewed interest in this class of compounds for the treatment of parasitic infections. In this review, the selectivity
openaire   +1 more source

Repurposing of conformationally-restricted cyclopentane-based AKT–inhibitors leads to discovery of potential and more selective antileishmanial agents than miltefosine

Bioorganic Chemistry, 2023
Ahmed H E Hassan, Mohammad Maqusood Alam, Trong-Nhat Phan   +2 more
exaly  

Evolution of chromone-like compounds as potential antileishmanial agents, through the 21st century

Expert Opinion on Drug Discovery, 2020
CARLOS F M Silva, Diana C G A Pinto, Pedro A Fernandes   +2 more
exaly  

Synthesis of 2,4,6-trisubstituted pyrimidine and triazine heterocycles as antileishmanial agents

Bioorganic and Medicinal Chemistry, 2006
Naresh Sunduru, Anu Agarwal, Sanjay Babu Katiyar   +2 more
exaly