Results 141 to 150 of about 4,370 (170)

Identification of the benzodiazepines as a new class of antileishmanial agent

Bioorganic & Medicinal Chemistry Letters, 2007
The continual increase in drug resistance; the lack of new chemotherapeutic agents; the toxicity of existing agents and the increasing morbidity with HIV co-infection mean the search for new antileishmanial agents has never been more urgent. We have identified the benzodiazepines as a structural class for antileishmanial hit optimisation, and ...
Clark, Rachael L., Carter, Katharine C., Mullen, Alexander B., Coxon, Geoffrey D., Owusu-Dapaah, George, McFarlane, Emma, Dao Duong Thi, M., Grant, M.H., Tettey, J.N.A., Mackay, Simon P.   +9 more
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Flavonoid Dimers as Novel, Potent Antileishmanial Agents

Journal of Medicinal Chemistry, 2012
The present study found that synthetic flavonoid dimers with either polyethylene glycol linker or amino ethyleneglycol linker have marked leishmanicidal activity. Compound 39 showed very consistent and promising leishmanicidal activity for both extracellular promastigotes (IC₅₀ ranging from 0.13 to 0.21 μM) and intracellular amastigotes (IC₅₀ = 0.63 μM)
Iris L K, Wong, Kin-Fai, Chan, Tak Hang, Chan, Larry M C, Chow   +3 more
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Antileishmanial effects of clofazimine and other antimycobacterial agents

Annals of Tropical Medicine & Parasitology, 1989
In the search for more effective alternatives to the presently-used antileishmanial drugs, the activity of the major groups of antimycobacterial compounds has been examined, both in vitro and in animal models of infection. In vitro, clofazimine was the most active compound tested, with a mean ED50 of 2.3 mg l-1 against Leishmania mexicana amazonensis ...
A T, Evans, S L, Croft, W, Peters, R A, Neal   +3 more
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Quinoxaline derivatives as potential antitrypanosomal and antileishmanial agents

Bioorganic & Medicinal Chemistry, 2018
Continuous efforts have been made to discover new drugs for the treatment of Chagas' disease, human African trypanosomiasis, and leishmaniasis. We have previously reported the synthesis and antileishmanial and antitrypanosomal (Y strain) properties of 2,3-disubstituted quinoxalines. Considering their promising antiparasitic potential, the present study
Juliana Cogo, Juan Cantizani, Ignacio Cotillo, Diego Pereira Sangi, Arlene Gonçalves Corrêa, Tânia Ueda-Nakamura, Benedito Prado Dias Filho, José Julio Martín, Celso Vataru Nakamura   +8 more
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Novel Catechol Derivatives of Arylimidamides as Antileishmanial Agents

Chemistry & Biodiversity, 2018
Two novel bis‐arylimidamide derivatives with terminal catechol moieties (9a and 10a) and two parent compounds with terminal phenyl groups (DB613 and DB884) were synthesized as dihydrobromide salts (9b and 10b). The designed compounds were hybrid molecules consisting of a catechol functionality embedded in an arylimidamide moiety.
Foroogh, Rezaei, Lotfollah, Saghaie, Razieh, Sabet, Afshin, Fassihi, Gholamreza, Hatam   +4 more
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Natural Products as a Source for Antileishmanial and Antitrypanosomal Agents

Combinatorial Chemistry & High Throughput Screening, 2016
Natural products are compounds extracted from plants, marine organisms, fungi or bacteria. Many researches for new drugs are based on these natural molecules, mainly by beneficial effects on health, health, efficacy, and therapeutic safety. Leishmaniosis, Chagas disease and African sleeping sickness are neglected diseases caused by the Leishmania and ...
Marcus Tullius, Scotti, Luciana, Scotti, Hamilton, Ishiki, Frederico Fávaro, Ribeiro, Rayssa Marques Duarte da, Cruz, Michelle Pedrosa de, Oliveira, Francisco Jaime Bezerra, Mendonça   +6 more
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Brominated chalcones as promising antileishmanial agents

Bioorganic & Medicinal Chemistry Letters
Leishmaniasis is a group of diseases caused by protozoa of the genus Leishmania. They are considered neglected diseases and are endemic to tropical and subtropical regions, affecting thousands of people annually. Leishmaniasis has a wide global distribution, present on four continents.
Tayssa S A, Barreto, Tamiris A C, Santos, Audrey R S T, Silva, Emmanoel V, Costa, Liciane A, Pinheiro, Roberta P M, Fernandes, Ricardo, Scher, Péricles B, Alves   +7 more
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Novel hybrid selenosulfonamides as potent antileishmanial agents

European Journal of Medicinal Chemistry, 2014
Diselenide and sulfonamide derivatives have recently attracted considerable interest as leishmanicidal agents in drug discovery. In this study, a novel series of sixteen hybrid selenosulfonamides has been synthesized and screened for their in vitro activity against Leishmania infantum intracellular amastigotes and THP-1 cells.
Ylenia Baquedano, Esther Moreno, Socorro Espuelas, Paul Nguewa, María Font, Kilian Jesús Gutierrez, Antonio Jiménez-Ruiz, Juan Antonio Palop, Carmen Sanmartín   +8 more
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4‐Aminoquinoline Derivatives as Potential Antileishmanial Agents

Chemical Biology & Drug Design, 2015
The leishmanicidal activity of a series of 4‐aminoquinoline (AMQ) derivatives was assayed against Leishmania amazonensis. This activity against the intracellular parasite was found stronger than for L. amazonensis promastigotes. Neither compound was cytotoxic against macrophages.
Luciana M R, Antinarelli, Rafael M P, Dias, Isabela O, Souza, Wallace P, Lima, Jacy, Gameiro, Adilson D, da Silva, Elaine S, Coimbra   +6 more
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A comprehensive review of chalcone derivatives as antileishmanial agents

European Journal of Medicinal Chemistry, 2018
Leishmaniasis is a group of infectious neglected tropical diseases caused by more than 20 pathogenic species of Leishmania sp. Due to the limitations of the current treatments available, chalcone moiety has been drawn with a lot of attention due to the simple chemistry and synthesis, being reported with antileishmanial activity in particular against ...
Marcos Vinícius Palmeira de Mello, Barbara de Azevedo Abrahim-Vieira, Thaisa Francielle Souza Domingos, Jessica Barbosa de Jesus, Ana Carolina Corrêa de Sousa, Carlos Rangel Rodrigues, Alessandra M. Teles de Souza   +6 more
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