Results 131 to 140 of about 4,370 (170)
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Synthesis and biological evaluation of chalcones as potential antileishmanial agents
European Journal of Medicinal Chemistry, 2014Antileishmanial activities of thirty-five synthetic chalcones have been examined. Among them, ten compounds (4, 6, 16, 22, 23, 24, 25, 29, 35 and 37) exhibited potent in vitro activity (IC50 range from 1.70 to 8 μM) against extracellular promastigotes and intracellular amastigotes form of Leishmania donovani.
Rahul Shivahare +2 more
exaly +3 more sources
Proteinase inhibitors as antileishmanial agents
Transactions of the Royal Society of Tropical Medicine and Hygiene, 1982Leishmania mexicana mexicana amastigote proteinase activity was largely inhibited by low concentrations of leupeptin, antipain and two epoxysuccinates, compounds known to affect cysteine proteinases. Of these inhibitors, only two had leishmanicidal activity. trans-Dicyclohexylepoxysuccinate at 10 microgram/ml inhibited the in vitro transformation of L.
G H, Coombs, D T, Hart, J, Capaldo
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Azaterphenyl diamidines as antileishmanial agents
Bioorganic & Medicinal Chemistry Letters, 2008Eighteen diamidino azaterphenyls and analogues were evaluated as anti-leishmanials; nine of the compounds gave IC50 values less than 1 microM, five exhibited values less than 0.40 microM, and two gave values less than 0.10 microM in a Leishmania donovani axenic amastigote assay.
Laixing, Hu +10 more
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Potential of Doxorubicin as an Antileishmanial Agent
The Journal of Parasitology, 1992Doxorubicin, a well characterized anticancer drug, was tested in vitro and in vivo for activity against Leishmania donovani. Activity in vitro was very high against both the promastigote and amastigote forms of this parasite with 50% effective dose (ED50) values on the order of 0.43 microM and 0.86 microM, respectively.
R, Sett, N, Basu, A K, Ghosh, P K, Das
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Manzamine alkaloids as antileishmanial agents: A review
European Journal of Medicinal Chemistry, 2015Leishmaniasis is considered as one of the most Neglected Tropical Diseases (NTDs) in the world, caused by protozoan parasites of the genus Leishmania. Leishmaniasis control profoundly depends upon chemotherapy which includes pentavalent antimonials, paromomycin, pentamidine, amphotericin B and miltefosine. Miltefosine is the only oral drug used for the
Penta, Ashok +2 more
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A Comprehensive Review of Patented Antileishmanial Agents
Pharmaceutical Patent Analyst, 2015On 14 October 2010, the WHO reported that more than 1 billion people worldwide who live in remote rural areas are affected by neglected tropical diseases. Leishmaniasis is caused by protozoa of more than 20 different species in humans. The three major forms of disease are cutaneous, mucocutaneous and visceral leishmaniasis (VL). Cutaneous leishmaniasis
Murugappan, Rama +2 more
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The Journal of Parasitology, 1987
present in the hemolymph of replete females only at 10-8 M. Thus, hemolymph components at this concentration or below may be affected by specific antibodies directed against them. The main advantage of using ELISA for detection of host antibodies in the hemolymph of ticks was the small volume of hemolymph required (about 0.2 Al/tick).
J D, Berman, J V, Gallalee
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present in the hemolymph of replete females only at 10-8 M. Thus, hemolymph components at this concentration or below may be affected by specific antibodies directed against them. The main advantage of using ELISA for detection of host antibodies in the hemolymph of ticks was the small volume of hemolymph required (about 0.2 Al/tick).
J D, Berman, J V, Gallalee
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Trypanothione as a Target in the Design of Antitrypanosomal and Antileishmanial Agents
Current Pharmaceutical Design, 2001Trypanothione is the key molecule in the defence mechanism of Trypanosoma and Leishmania against oxidative stress. The uniqueness of trypanothione makes the metabolism of this molecule an attractive target in antitrypanosomal and antileishmanial drug design. It became clear that this antioxidant cascade can be considered as the "Achilles heel" of these
Augustyns, K. +4 more
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Arylanthranilodinitriles: A New Biaryl Class of Antileishmanial Agents.
ChemInform, 2006AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Fateh V, Singh +3 more
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Synthesis and evaluation of original amidoximes as antileishmanial agents
Bioorganic & Medicinal Chemistry, 2010An original series of amidoxime derivatives was synthesized using manganese(III) acetate, Buchwald-Hartwig and Heck reactions. Two amidoximes (39 and 52) showed interesting in vitro activities toward Leishmania donovani promastigotes, exhibiting 8.3 and 8.8 μM IC(50) values.
Bouhlel, Ahlem +6 more
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