Results 81 to 90 of about 4,028,312 (182)

Effect of mass dihydroartemisinin-piperaquine administration in southern Mozambique on the carriage of molecular markers of antimalarial resistance.

PLoS ONE, 2020
BackgroundMass drug administration (MDA) can rapidly reduce the burden of Plasmodium falciparum (Pf). However, concerns remain about its contribution to select for antimalarial drug resistance.MethodsWe used Sanger sequencing and real-time PCR to ...
Himanshu Gupta, Beatriz Galatas, Arlindo Chidimatembue, Silvie Huijben, Pau Cisteró, Gloria Matambisso, Lidia Nhamussua, Wilson Simone, Quique Bassat, Didier Ménard, Pascal Ringwald, N Regina Rabinovich, Pedro L Alonso, Francisco Saúte, Pedro Aide, Alfredo Mayor   +15 more
doaj   +1 more source

Synthesis, Characterization, and In Vitro Evaluation of New Amino‐Alcohol Quinolines as Promising Antimycobacterial Agents

ChemMedChem, Volume 21, Issue 20, 28 October 2026.
Nontuberculous mycobacteria (NTM) mainly Mycobacterium avium complex (MAC), are emerging pathogens responsible for pulmonary infections. The efficacy of the standard treatment is therefore compromised by the emergence of intrinsic and acquired resistance in MAC.
Elise Si Ahmed Charrier, François Peltier, Jean‐François Raimbert, Marie Perret, Claire Andréjak, Alexandra Dassonville‐Klimpt, Pascal Sonnet   +6 more
wiley   +1 more source

Antimalarial drug resistance.

, 2004
Malaria, the most prevalent and most pernicious parasitic disease of humans, is estimated to kill between one and two million people, mainly children, each year.
Nicholas J. White, White, Nicholas
core   +1 more source

World Antimalarial Resistance Network (WARN) IV: Clinical pharmacology

Malaria Journal, 2007
A World Antimalarial Resistance Network (WARN) database has the potential to improve the treatment of malaria, through informing current drug selection and use and providing a prompt warning of when treatment policies need changing.
Gbotosho Grace O, Plowe Christopher V, Randrianarivelojosia Milijaona, Olliaro Piero, Ogundahunsi Olumide, Lindegardh Niklas, Barnes Karen I, Watkins William M, Sibley Carol H, White Nicholas J   +9 more
doaj   +1 more source

Deprotective Alkylation: A Platform for Alcohol‐to‐Amine Interconversion Using Nonafluoromesitylenesulfonamides

Angewandte Chemie International Edition, Volume 65, Issue 43, 19 October 2026.
The straightforward conversion of alcohols to tertiary or secondary amines employing Nms‐amides in a single operation is described. The transformation features broad functional group tolerance and high stereospecificity, underscoring its utility in the synthesis of isotope‐labeled pharmaceuticals.
Jakub Brześkiewicz, Kunj Kapur, Boris Maryasin, Nuno Maulide   +3 more
wiley   +1 more source

The effects of pharmacogenetics on pharmacokinetics of artemisinin-based combinations in malaria patients [PDF]

, 2009
Malaria is a vector-borne infectious disease caused by protozoan parasites of the genus Plasmodium. If not treated appropriately, human P. falciparum malaria can quickly become life-threatening, leading to an estimated 900’000 annual deaths globally. Key
Hodel, Eva Maria
core   +1 more source

Should New Anti-Malarial Drugs be Subsidized? [PDF]

We use analytical and numerical models to explain and quantify the welfare effects of subsidies for artemisinin combination treatments (ACTs), a valuable new class of antimalarial drugs.
Klein, Eili, Parry, Ian W.H., Smith, David L., Laxminarayan, Ramanan   +3 more
core  

Drug coverage in treatment of malaria and the consequences for resistance evolution--evidence from the use of sulphadoxine/pyrimethamine. [PDF]

, 2010
BACKGROUND\ud \ud It is argued that, the efficacy of anti-malarials could be prolonged through policy-mediated reductions in drug pressure, but gathering evidence of the relationship between policy, treatment practice, drug pressure and the evolution of ...
Abdulla, Salim, Bloland, Peter, Malisa, Allen L, Roper, Cally, Allen L Malisa, Salim Abdulla, Cally Roper, Patrick S Kachur, Peter Bloland, Hassan Mshinda, Kachur, Patrick S, Richard J Pearce, Pearce, Richard J, Mshinda, Hassan   +13 more
core   +1 more source

Novel polymorphisms in Plasmodium falciparum ABC transporter genes are associated with major ACT antimalarial drug resistance.

PLoS ONE, 2011
Chemotherapy is a critical component of malaria control. However, the most deadly malaria pathogen, Plasmodium falciparum, has repeatedly mounted resistance against a series of antimalarial drugs used in the last decades.
Maria Isabel Veiga, Pedro Eduardo Ferreira, Louise Jörnhagen, Maja Malmberg, Aminatou Kone, Berit Aydin Schmidt, Max Petzold, Anders Björkman, Francois Nosten, Jose Pedro Gil   +9 more
doaj   +1 more source

Induction of Multidrug Tolerance in Plasmodium falciparum by Extended Artemisinin Pressure

Emerging Infectious Diseases, 2015
Plasmodium falciparum resistance to artemisinin derivatives in Southeast Asia threatens global malaria control strategies. Whether delayed parasite clearance, which exposes larger parasite numbers to artemisinins for longer times, selects higher-grade ...
Sandie Ménard, Tanila Ben Haddou, Arba Pramundita Ramadani, Frédéric Ariey, Xavier Iriart, Johann Beghain, Christiane Bouchier, Benoit Witkowski, Antoine Berry, Odile Mercereau-Puijalon, Françoise Benoit-Vical   +10 more
doaj   +1 more source