Results 61 to 70 of about 4,028,312 (182)

“The Smell Makes Us Hungry”: When Food Is Not Medicine in Highland Madagascar

Culture, Agriculture, Food and Environment, EarlyView.
ABSTRACT In the wake of major disruptions to global supply chains during the Covid‐19 pandemic, the island nation of Madagascar pursued initiatives for auto‐suffisance, self‐sufficiency, in food supplies and medical treatments. Farming communities in the central highlands experienced an injunction to expand cultivation of both subsistence crops and ...
Gabrielle Robbins
wiley   +1 more source

Monitoring antimalarial safety and tolerability in clinical trials: a case study from Uganda. [PDF]

, 2008
BACKGROUND: New antimalarial regimens, including artemisinin-based combination therapies (ACTs), have been adopted widely as first-line treatment for uncomplicated malaria.
Njama-Meya Denise, Staedke Sarah G, Catherine Maiteki-Sebuguzi, Sarah G Staedke, Denise Njama-Meya, Moses R Kamya, Kristin Banek, Maiteki-Sebuguzi Catherine, Grant Dorsey, Yeka Adoke, Jagannathan, Prasanna, Dorsey, Grant, Talisuna, Ambrose O, Arthur Mpimbaza, Dorsey Grant, Ambrose O Talisuna, Rosenthal Philip J, Hasifa Bukirwa, Jagannathan Prasanna, Maiteki-Sebuguzi, Catherine, Rosenthal, Philip J, Tamara D Clark, Clark Tamara D, Yeka, Adoke, Banek, Kristin, Nzarubara Bridget, Staedke, Sarah G, Prasanna Jagannathan, Banek Kristin, Mpimbaza Arthur, Bukirwa, Hasifa, Nzarubara, Bridget, Philip J Rosenthal, Njama-Meya, Denise, Clark, Tamara D, Adoke Yeka, Mpimbaza, Arthur, Kamya Moses R, Bridget Nzarubara, Kamya, Moses R, Bukirwa Hasifa, Wabwire-Mangen Fred, Talisuna Ambrose O, Fred Wabwire-Mangen, Wabwire-Mangen, Fred   +44 more
core   +1 more source

World Antimalarial Resistance Network (WARN) II: In vitro antimalarial drug susceptibility

Malaria Journal, 2007
Intrinsic resistance of Plasmodium falciparum is clearly a major determinant of the clinical failure of antimalarial drugs. However, complex interactions between the host, the parasite and the drug obscure the ability to define parasite drug resistance ...
Ringwald Pascal, Fukuda Mark M, Wongsrichanalai Chansuda, Le Bras Jacques, Fandeur Thierry, Bacon David J, Jambou Ronan, Sibley Carol, Kyle Dennis E   +8 more
doaj   +1 more source

PEG400 regulates Falcipain 2 activity through an allosteric mechanism

The FEBS Journal, EarlyView.
Falcipain‐2 can potentially be leveraged as a drug target due to its critical role as a haemoglobinase during the intra‐erythrocytic stage of Plasmodium falciparum. Here, we investigate the regulation of the proteolytic and haemoglobinase activity of falcipain‐2 in the presence of polyethylene glycol.
Bikram Nath, Subhoja Chakraborty, Sampa Biswas   +2 more
wiley   +1 more source

Genetic diversity of next generation antimalarial targets: A baseline for drug resistance surveillance programmes

International Journal for Parasitology: Drugs and Drug Resistance, 2017
Drug resistance is a recurrent problem in the fight against malaria. Genetic and epidemiological surveillance of antimalarial resistant parasite alleles is crucial to guide drug therapies and clinical management.
Ana Rita Gomes, Matt Ravenhall, Ernest Diez Benavente, Arthur Talman, Colin Sutherland, Cally Roper, Taane G. Clark, Susana Campino   +7 more
doaj   +1 more source

Transgenic selection and underlying mechanisms in apicomplexan parasites

The FEBS Journal, EarlyView.
Transgenic selection markers have driven genetic engineering in apicomplexans, enabling precise, iterative experiments. This review discusses mechanistic details of drug selection markers, strategies for marker recycling, and practical considerations for several clinically relevant parasites.
Swaroop Peddiraju, Rakhee Lohia, Nishith Gupta   +2 more
wiley   +1 more source

Tissue Resident Memory Cells: Friend or Foe?

Immunology, EarlyView.
Tissue‐resident memory T cells (TRM cells) are specialised immune cells in barrier tissues like the lungs, skin and gut, providing rapid host defence and tumour surveillance. Their retention and differentiation are regulated by molecules such as CD69, CD103 and TGF‐β. Dysregulation of TRM cells can lead to chronic activation, driving conditions such as
Chidimma F. Chude, Jude E. Uzonna, Janilyn Arsenio   +2 more
wiley   +1 more source

Antimalarial drug discovery and development: Assay system challenges and the translational relevance of Plasmodium knowlesi–baboon model

Journal of Advanced Biotechnology and Experimental Therapeutics
Drug resistance has rendered most of the antimalarial drugs ineffective. In addition, utilization of some of the antimalarial drugs has been limited by their toxic effects due to prolonged treatment regimens. The long treatment period affects compliance,
Simeon Mogaka, Faith Onditi, Kenneth Ogila, Clesson Higashi, Hastings Ozwara   +4 more
doaj   +1 more source

Chemical Characterisation of Steam‐Distilled Essential Oils From Lemongrass (Cymbopogon citratus Stapf) and Ginger Rhizomes (Zingiber officinale Roscoe) Using FTIR and GC‐MS: Comparison of Phytochemical Composition

Phytochemicals in Food and Medicine, Volume 1, Issue 4, December 2026.
Illustration of essential oil extraction coupled with characterisation. ABSTRACT Essential oils from lemongrass and ginger rhizomes contain bioactive compounds with potential for nutraceutical and pharmaceutical applications. In this study, essential oils were extracted from ginger rhizomes and lemongrass by the steam distillation method, using a ...
Abdullahi Nwaha Isah, Umi Aisah Asli, Simon Zambiri, Lukman Abdulkadir, Abuhuraira Otto Ibrahim, Esimi Jimoh Sezuo   +5 more
wiley   +1 more source

Repurposing Drugs for Malaria through a Human Dose Prediction: A Case Study with Berzosertib

Clinical Pharmacology &Therapeutics, Volume 120, Issue 5, Page 1315-1325, November 2026.
Repurposing drugs whose clinical safety has been established offers a valuable approach to reduce the cost and time associated with the development of new drugs for malaria. Here, we investigate the potential to repurpose the anticancer kinase inhibitor berzosertib for the treatment of malaria, by assessing whether a predicted efficacious human dose ...
Devasha Redhi, Mwila Mulubwa, Mmakwena M. Mmonwa, Mathew Njoroge, Liezl Krugmann, Kelly Chibale   +5 more
wiley   +1 more source